Prosecution Insights
Last updated: October 27, 2026

Salk Institute for Biological Studies

Technology area: Biotechnology & Pharmaceuticals

12 pending office actions • 8 art units • 11 examiners • 0 of 12 (0%) have an AI response strategy ready • 9 patents granted in the last 365 days

Analysis

The Salk Institute for Biological Studies maintains a robust prosecution profile with 12 pending office actions in the Biotechnology & Pharmaceuticals technology area. These matters are distributed across 11 distinct examiners and 8 distinct art units. The breadth of art units involved suggests a diverse research portfolio that spans multiple specialized biological and pharmaceutical disciplines, requiring a versatile legal approach to handle various examination styles.

The busiest examiner for the institute is Bretz, Corey Lane, who is currently managing 2 pending office actions. This examiner is the only individual in the data set handling more than a single matter for the organization. The remaining pending office actions are spread among the other distinct examiners, indicating a highly decentralized review process at the patent office that avoids concentration with any single official.

With 12 pending office actions active, the institute's legal strategy must account for the varied requirements of 8 distinct art units. This level of distribution requires coordinating with a large group of 11 distinct examiners, which may lead to differing prosecution timelines across the portfolio. The high ratio of examiners to actions suggests that the institute's current filings are being treated as independent technical inquiries rather than a clustered group of related applications.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

12
Total Pending OAs
7
Non-Final OAs
5
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 3 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

3
Overdue
0
Due this week
0
Due this month
0
Due in next 60 days
0
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 3 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (3)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

5
Hard (42%)
5
Medium (42%)
2
Easy (17%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other2 (17%)
§103 only1 (8%)
§112 only1 (8%)
Double-patenting only1 (8%)
Double-patenting + other4 (33%)
Multi-statute (no §101)3 (25%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

12
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

120 h
Manual time on pending OAs
24 h
Time saved (low, 20%)
42 h
Time saved (mid, 35%)
1.1 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
BRETZ, COREY LANE 2 0.0% +0.0%
MEYER, GEORGE WILLIAM 1 100.0% +0.0%
CHATTERJEE, JAYANTA 1 44.0% +70.1%
GILL, RACHEL B 1 65.4% +28.8%
SHIN, DANA H 1 26.9% +26.9%
LEONARD, ARTHUR S 1 50.5% +50.4%
VANHORN, ABIGAIL LOUISE 1 46.8% +22.7%
KIM, TAEYOON 1 51.4% +52.2%
PRONZATI, GINA 1 65.9% +48.3%
LIPPOLIS, ALEXANDRA ROSE 1 47.2% +63.6%

Hard Cases (8)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17769524 METHODS FOR MODULATING HUMAN L1 RETROTRANSPOSONS RNA AND COMPOSITIONS FOR USE THEREIN KIM, TAEYOON 147d overdue
17637058 COMPOSITIONS AND METHODS FOR IN VIVO GENE EDITING LIPPOLIS, ALEXANDRA ROSE 125d overdue
18954772 IRON MAN (IMA) OVEREXPRESSION INCREASES DISEASE RESISTANCE MEYER, GEORGE WILLIAM —
18840877 COMPOSITIONS AND METHODS FOR INCREASING PERIDERM IN PLANT ROOTS CHATTERJEE, JAYANTA —
18797069 HSV-1 ONCOLYTIC VIRUS THERAPIES THAT SPECIFICALLY KILL ALT DEPENDENT CANCERS GILL, RACHEL B —
18288772 MULTIPLEX CRISPR/Cas9-MEDIATED TARGET GENE ACTIVATION SYSTEM SHIN, DANA H —
18151093 RECOMBINANT ADENOVIRUS GENOME HAVING A SYNTHETIC TRANSCRIPTIONAL UNIT AND TWO STEP TRANSCRIPTIONAL REGULATION AND AMPLIFICATION BRETZ, COREY LANE —
17741311 COMPOSITIONS AND METHODS FOR HIGH-EFFICIENCY RECOMBINATION OF RNA MOLECULES BRETZ, COREY LANE —

Interview Candidates (8)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17769524 METHODS FOR MODULATING HUMAN L1 RETROTRANSPOSONS RNA AND COMPOSITIONS FOR USE THEREIN KIM, TAEYOON 147d overdue
17637058 COMPOSITIONS AND METHODS FOR IN VIVO GENE EDITING LIPPOLIS, ALEXANDRA ROSE 125d overdue
18028751 PATIENT SELECTION BIOMARKERS FOR TREATMENT WITH ULK INHIBITORS VANHORN, ABIGAIL LOUISE 19d overdue
18840877 COMPOSITIONS AND METHODS FOR INCREASING PERIDERM IN PLANT ROOTS CHATTERJEE, JAYANTA —
18797069 HSV-1 ONCOLYTIC VIRUS THERAPIES THAT SPECIFICALLY KILL ALT DEPENDENT CANCERS GILL, RACHEL B —
18288772 MULTIPLEX CRISPR/Cas9-MEDIATED TARGET GENE ACTIVATION SYSTEM SHIN, DANA H —
18302962 SYNTHETIC ADENOVIRUSES TARGETING BONE TISSUE AND USES THEREOF LEONARD, ARTHUR S —
17681538 ADENOVIRAL ASSEMBLY METHOD PRONZATI, GINA —

Top Art Units

Art UnitApps
1635 3
1662 2
1631 2
1671 1
1636 1
1633 1
1637 1
1626 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18954772 IRON MAN (IMA) OVEREXPRESSION INCREASES DISEASE RESISTANCE MEYER, GEORGE WILLIAM 1662 §103§112 Non-Final OA — Pending Nov 21, 2024
18840877 COMPOSITIONS AND METHODS FOR INCREASING PERIDERM IN PLANT ROOTS CHATTERJEE, JAYANTA 1662 §102§103§112 Non-Final OA — Pending Aug 22, 2024
18797069 HSV-1 ONCOLYTIC VIRUS THERAPIES THAT SPECIFICALLY KILL ALT DEPENDENT CANCERS GILL, RACHEL B 1671 §101§103§112DP Non-Final OA — Pending Aug 07, 2024
18288772 MULTIPLEX CRISPR/Cas9-MEDIATED TARGET GENE ACTIVATION SYSTEM SHIN, DANA H 1635 §103§112DPOther Non-Final OA — Pending Oct 27, 2023
18302962 SYNTHETIC ADENOVIRUSES TARGETING BONE TISSUE AND USES THEREOF LEONARD, ARTHUR S 1631 §112 Final Rejection — Pending Apr 19, 2023
18028751 PATIENT SELECTION BIOMARKERS FOR TREATMENT WITH ULK INHIBITORS VANHORN, ABIGAIL LOUISE 1636 §103DP Final Rejection 19d overdue Pending Apr 12, 2023
18151093 RECOMBINANT ADENOVIRUS GENOME HAVING A SYNTHETIC TRANSCRIPTIONAL UNIT AND TWO STEP TRANSCRIPTIONAL REGULATION AND AMPLIFICATION BRETZ, COREY LANE 1635 §102§103§112DP Non-Final OA — Pending Jan 06, 2023
17741311 COMPOSITIONS AND METHODS FOR HIGH-EFFICIENCY RECOMBINATION OF RNA MOLECULES BRETZ, COREY LANE 1635 §112DP Non-Final OA — Pending May 10, 2022
17769524 METHODS FOR MODULATING HUMAN L1 RETROTRANSPOSONS RNA AND COMPOSITIONS FOR USE THEREIN KIM, TAEYOON 1631 §102§103 Final Rejection 147d overdue Pending Apr 15, 2022
17681538 ADENOVIRAL ASSEMBLY METHOD PRONZATI, GINA 1633 DP Final Rejection — Pending Feb 25, 2022
17637058 COMPOSITIONS AND METHODS FOR IN VIVO GENE EDITING LIPPOLIS, ALEXANDRA ROSE 1637 §101§102§103 Final Rejection 125d overdue Pending Feb 21, 2022
18403664 METHODS OF TREATING NEURODEGENERATIVE DISEASES OR CONDITIONS PATEL, SAGAR S 1626 §103 Non-Final OA — Pending Jan 03, 2024

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Frequently Asked Questions

How many pending USPTO office actions does Salk Institute for Biological Studies have?

Salk Institute for Biological Studies has 12 pending office actions as of October 2026, spread across 8 art units and 11 examiners.

Which USPTO examiner handles the most Salk Institute for Biological Studies applications?

Corey Lane Bretz has the most, with 2 of Salk Institute for Biological Studies's pending office actions.

What technology area are Salk Institute for Biological Studies's patent applications in?

Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.

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