Prosecution Insights
Last updated: August 06, 2026

Milstein Zhang & Wu LLC

14 pending office actions • 8 clients • 12 examiners • 10 art units • 0 of 14 (0%) have an AI response strategy ready

Quality Metrics (n=979 apps, methodology: how we score firms)

83.0%
Allowance Rate
n=979
+0.88σ
Allowance Rate (norm)
n=979
3.8
OAs to Allowance
n=424
-0.08σ
OAs to Allow (norm)
n=424
1075 days
Time to Allowance
n=424
+16.7pp
Interview Lift
n=979
25.2%
RCE Rate
n=979
1.4%
Appeal Rate
n=979

Rejection Performance (% of received rejections ultimately overcome)

85.4%
§101 Overcome
n=41
80.0%
§102 Overcome
n=220
83.5%
§103 Overcome
n=328
84.8%
§112 Overcome
n=303

Specialization & Scale

A61K, A61P, C07D
Top CPC Subclasses
34%
Top-3 CPC Share
n=979
0
Practitioners
n=979
Apps / Practitioner
n=979 (min 20)

Portfolio Summary

14
Total Pending OAs
7
Non-Final OAs
7
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 12 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

6
Overdue
0
Due this week
4
Due this month
2
Due in next 60 days
0
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 12 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (6)Due ≤ 30 days (4)Due ≤ 60 days (2)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

7
Hard (50%)
4
Medium (29%)
3
Easy (21%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§103 only3 (21%)
§112 only3 (21%)
Double-patenting + other1 (7%)
Multi-statute (no §101)7 (50%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

14
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

140 h
Manual time on pending OAs
28 h
Time saved (low, 20%)
49 h
Time saved (mid, 35%)
1.2 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
WILLIS, DOUGLAS M 2 82.4% +19.5%
VU, JAKE MINH 2 40.6% +27.4%
BAEK, BONG-SOOK 1 41.7% +69.8%
COLEMAN, BRENDA LIBBY 1 74.7% +15.5%
KIM, SEONG JONG 1
COPPINS, JANET L 1 72.9% +25.5%
REYNOLDS, FRED H 1 33.1% +39.0%
YOON, TAE H 1 66.5% +24.7%
BARSKY, JARED 1 50.3% +23.1%
POPA, ILEANA 1 21.5% +14.6%

Quick Wins (2)

Cases in front of an examiner with an allow rate of 80%+ where the difficulty is Easy or Medium. The top 2 ordered by deadline are shown.

App #TitleExaminerDue in
18134495 BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF WILLIS, DOUGLAS M 42d
18630270 BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF WILLIS, DOUGLAS M

Hard Cases (8)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18219656 COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES VU, JAKE MINH 154d overdue
17790697 ALKYLATED NUCLEOSIDES, AND COMPOSITIONS AND METHODS THEREOF FOR NUCLEIC ACID DELIVERY CHO, DAVID H 19d overdue
18519269 Pharmaceutical Mixture Comprising Amorphous Pitolisant KIM, SEONG JONG 18d overdue
18648420 ISO-OSMOTIC AND NEAR ISO-OSMOTIC OXYGEN THERAPEUTIC FORMULATIONS AND METHODS THEREOF BAEK, BONG-SOOK 4d overdue
17616166 COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES VU, JAKE MINH 16d
18088544 POLYMERIC NANOPARTICLES AND DERIVATIVES THEREOF FOR NUCLEIC ACID BINDING AND DELIVERY POPA, ILEANA 28d
17719015 High-Density Flagellin-Displaying Virus-Like Particle As Vaccine Carrier LOUNTOS, GEORGE THEMISTOCLIS 30d
18279931 PHOTOCAGED CITRULLINE ANALOGS AND METHODS FOR SITE-SPECIFIC INCORPORATION OF CITRULLINE INTO PROTEINS REYNOLDS, FRED H 57d

Interview Candidates (11)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18219656 COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES VU, JAKE MINH 154d overdue
18648420 ISO-OSMOTIC AND NEAR ISO-OSMOTIC OXYGEN THERAPEUTIC FORMULATIONS AND METHODS THEREOF BAEK, BONG-SOOK 4d overdue
18233077 PROTEIN-POLYMER NANOASSEMBLIES AND INTRACELLULAR PROTEIN DELIVERY YOON, TAE H 3d overdue
18574248 CRYSTALLINE POLYMORPHS OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR, AND COMPOSITIONS AND METHODS THEREOF COLEMAN, BRENDA LIBBY 2d overdue
18202033 COMPOSITIONS OF BERBERINE URSODEOXYCHOLATE AND METHODS THEREOF FOR TREATING PRIMARY SCLEROSING CHOLANGITIS BARSKY, JARED 15d
17616166 COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES VU, JAKE MINH 16d
18088544 POLYMERIC NANOPARTICLES AND DERIVATIVES THEREOF FOR NUCLEIC ACID BINDING AND DELIVERY POPA, ILEANA 28d
18134495 BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF WILLIS, DOUGLAS M 42d

Client Portfolio (8 clients)

Top Art Units

Art UnitApps
16243
16282
16182
16111
16211
16581
17621
16331
16931
16521

Pending Office Actions

App #TitleClientExaminerArt UnitStatutesStatusDue inAIFiled
18648420 ISO-OSMOTIC AND NEAR ISO-OSMOTIC OXYGEN THERAPEUTIC FORMULATIONS AND METHODS THEREOF NuvOx Pharma LLC BAEK, BONG-SOOK 1611 §103§112 Non-Final OA 4d overdue Pending Apr 28, 2024
18630270 BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF Shenzhen Hightide Biopharmaceutical, Ltd. WILLIS, DOUGLAS M 1624 §112DP Non-Final OA Pending Apr 09, 2024
18574248 CRYSTALLINE POLYMORPHS OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR, AND COMPOSITIONS AND METHODS THEREOF Crimson Biopharm Inc. COLEMAN, BRENDA LIBBY 1624 §112Other Non-Final OA 2d overdue Pending Dec 26, 2023
18519269 Pharmaceutical Mixture Comprising Amorphous Pitolisant Alfred E. Tiefenbacher GmbH & Co. KG KIM, SEONG JONG 1621 §102§103 Non-Final OA 18d overdue Pending Nov 27, 2023
18280548 METAP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF Canwell Biotech Limited COPPINS, JANET L 1628 §112 Non-Final OA Pending Sep 06, 2023
18279931 PHOTOCAGED CITRULLINE ANALOGS AND METHODS FOR SITE-SPECIFIC INCORPORATION OF CITRULLINE INTO PROTEINS UNIVERSITY OF MASSACHUSETTS REYNOLDS, FRED H 1658 §102§103 Non-Final OA 57d Pending Sep 01, 2023
18233077 PROTEIN-POLYMER NANOASSEMBLIES AND INTRACELLULAR PROTEIN DELIVERY UNIVERSITY OF MASSACHUSETTS YOON, TAE H 1762 §103 Final Rejection 3d overdue Pending Aug 11, 2023
18219656 COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES Microvascular Therapeutics, LLC VU, JAKE MINH 1618 §102§103Other Final Rejection 154d overdue Pending Jul 08, 2023
18202033 COMPOSITIONS OF BERBERINE URSODEOXYCHOLATE AND METHODS THEREOF FOR TREATING PRIMARY SCLEROSING CHOLANGITIS Shenzhen Hightide Biopharmaceutical Ltd. BARSKY, JARED 1628 §103Other Final Rejection 15d Pending May 25, 2023
18134495 BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF Shenzhen Hightide Biopharmaceutical, Ltd. WILLIS, DOUGLAS M 1624 §112 Final Rejection 42d Pending Apr 13, 2023
18088544 POLYMERIC NANOPARTICLES AND DERIVATIVES THEREOF FOR NUCLEIC ACID BINDING AND DELIVERY UNIVERSITY OF MASSACHUSETTS POPA, ILEANA 1633 §103Other Final Rejection 28d Pending Dec 24, 2022
17790697 ALKYLATED NUCLEOSIDES, AND COMPOSITIONS AND METHODS THEREOF FOR NUCLEIC ACID DELIVERY Microvascular Therapeutics, LLC CHO, DAVID H 1693 §103§112 Final Rejection 19d overdue Pending Jul 01, 2022
17719015 High-Density Flagellin-Displaying Virus-Like Particle As Vaccine Carrier University of Rhode Island Board of Trustees LOUNTOS, GEORGE THEMISTOCLIS 1652 §103§112 Non-Final OA 30d Pending Apr 12, 2022
17616166 COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES Microvascular Therapeutics, LLC VU, JAKE MINH 1618 §103§112 Final Rejection 16d Pending Dec 02, 2021

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