Technology areas: Biotechnology & Pharmaceuticals • Chemistry & Materials
174 pending office actions • 92 art units • 159 examiners • 0 of 174 (0%) have an AI response strategy ready • 183 patents granted in the last 365 days
Massachusetts Institute of Technology has 188 pending office actions in Biotechnology & Pharmaceuticals. Those matters span 173 distinct examiners and 96 distinct art units, creating a widely distributed prosecution profile. Portfolio oversight should therefore combine strong docket controls with technical and examiner-specific review.
WEHBE, ANNE MARIE SABRINA is the busiest identified examiner, with 3 pending matters. The cluster may warrant targeted examiner research, but it does not define the portfolio’s overall structure. Counsel should use matter-level analysis to account for differences in claim scope, prior art, and art-unit practice.
Based on the USPTO statutory response window for each pending office action. 50 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.
Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 50 of the docket's apps have a known mailing date.
Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.
| Bucket | Cases |
|---|---|
| §101 only | 1 (1%) |
| §101 + other | 22 (13%) |
| §103 only | 47 (27%) |
| §102 only | 8 (5%) |
| §112 only | 12 (7%) |
| Double-patenting only | 4 (2%) |
| Double-patenting + other | 16 (9%) |
| Multi-statute (no §101) | 63 (36%) |
| No statute on record | 1 (1%) |
How the docket's pending cases split across USPTO tech-center bands.
Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.
| Examiner | Apps on this docket | Allow rate | Interview lift |
|---|---|---|---|
| WEHBE, ANNE MARIE SABRINA | 3 | 57.3% | +43.3% |
| RYAN, DOUGLAS CHARLES | 3 | 38.2% | +48.4% |
| MARVICH, MARIA | 2 | 55.0% | +28.0% |
| LI, JUN | 2 | 54.5% | +57.0% |
| MENDEZ, ZULMARIAM | 2 | 66.1% | +21.3% |
| LIPPOLIS, ALEXANDRA ROSE | 2 | 47.2% | +63.6% |
| BELLAH, JEFFREY LAWRENCE | 2 | 100.0% | +0.0% |
| PERRIN, CLARE M | 2 | 68.3% | +42.6% |
| HUTSON, RICHARD G | 2 | 65.1% | +52.9% |
| LEE, JAE W | 2 | 65.6% | +38.5% |
Cases in front of an examiner with an allow rate of 80%+ where the difficulty is Easy or Medium. The top 1 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 18564338 | CO-MAPPING TRANSCRIPTIONAL STATES AND PROTEIN HISTOLOGY | BELLAH, JEFFREY LAWRENCE | — |
Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17941016 | Materials and Methods for Biosorption of Micropollutants from Aqueous Solutions | PERRIN, CLARE M | 140d overdue |
| 17758918 | HYBRID CORE MAGNETICS | NGUYEN, TUYEN T | 110d overdue |
| 16095207 | NOVEL CRISPR ENZYMES AND SYSTEMS | ZHENG, LI | 88d overdue |
| 17439251 | ISOLATION, ENRICHMENT AND EXPANSION OF CONE PROGENITOR CELLS AND USES THEREOF | MOSS, NATALIE M | 70d overdue |
| 18507676 | DEVICES, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING WIRELESS STENT-BASED INTERFACES TO THE NERVOUS SYSTEM | HENSON, DEVIN B | 51d overdue |
| 18314919 | Catalytic process for selective polyolefin hydrogenolysis | NGUYEN, TAM M | 51d overdue |
| 18438110 | MULTIPLANE NANOPHOTONIC VOXEL ENGINE | VU, PHU | 46d overdue |
| 17440618 | CONTROL OF NITROGEN FIXATION IN RHIZOBIA THAT ASSOCIATE WITH CEREALS | BARRON, SEAN C | 28d overdue |
Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17941016 | Materials and Methods for Biosorption of Micropollutants from Aqueous Solutions | PERRIN, CLARE M | 140d overdue |
| 17707951 | ENGINEERED ADENO-ASSOCIATED VIRUS CAPSIDS | WEHBE, ANNE MARIE SABRINA | 99d overdue |
| 18248199 | HELITRON MEDIATED GENETIC MODIFICATION | LIPPOLIS, ALEXANDRA ROSE | 25d overdue |
| 18971207 | REACTION SCHEMES INVOLVING ACIDS AND BASES; REACTORS COMPRISING SPATIALLY VARYING CHEMICAL COMPOSITION GRADIENTS; AND ASSOCIATED SYSTEMS AND METHODS | LI, JUN | 4d overdue |
| 17922126 | USE OF REACTOR OUTPUTS TO PURIFY MATERIALS, AND RELATED SYSTEMS | LI, JUN | 4d overdue |
| 17085937 | BACTERIAL DEFENSE SYSTEMS AND METHODS OF IDENTIFYING THEREOF | RYAN, DOUGLAS CHARLES | 3d overdue |
| 16954032 | CAS12A SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED RNA BASE EDITING | HUTSON, RICHARD G | 20d |
| 17786168 | GENOME EDITING USING REVERSE TRANSCRIPTASE ENABLED AND FULLY ACTIVE CRISPR COMPLEXES | LEE, JAE W | 33d |
| Art Unit | Apps |
|---|---|
| 1636 | 7 |
| 1631 | 6 |
| 1637 | 6 |
| 1634 | 5 |
| 1635 | 5 |
| 1652 | 5 |
| 1632 | 5 |
| 1684 | 5 |
| 1732 | 4 |
| 1794 | 4 |
| App # | Title | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|
| 19449304 | ENGINEERED MUSCLE TARGETING COMPOSITIONS | MARVICH, MARIA | 1634 | §112 | Non-Final OA | — | Pending | Jan 14, 2026 |
| 19390128 | ENGINEERED ADENO-ASSOCIATED VIRUS CAPSIDS | WEHBE, ANNE MARIE SABRINA | 1634 | §103 | Final Rejection | — | Pending | Nov 14, 2025 |
| 19355982 | ENGINEERED MUSCLE TARGETING COMPOSITIONS | MARVICH, MARIA | 1634 | §112DP | Non-Final OA | — | Pending | Oct 10, 2025 |
| 19156119 | DETERMINATION OF PATH WITH ENHANCED OR OPTIMIZED COLLECTION AND TIME IN DYNAMIC ENVIRONMENTS | KAN, YURI | 3662 | §101§112 | Non-Final OA | — | Pending | Aug 13, 2025 |
| 19290464 | FINGER INSERTS FOR A NAILFOLD IMAGING DEVICE | BROWN, HELENE CATHERINE | 3797 | §103Other | Non-Final OA | — | Pending | Aug 05, 2025 |
| 19100973 | ROBOT AVATAR | GE, JIN | 2619 | §102 | Non-Final OA | — | Pending | Feb 04, 2025 |
| 18996502 | DEFORMATION SENSING AND OBJECT IDENTIFICATION WITH COLOR-DYNAMIC MECHANO-RESPONSIVE PHOTONIC MATERIALS | AHMED, JAMIL | 2877 | §103 | Non-Final OA | — | Pending | Jan 17, 2025 |
| 19011409 | BRANCHED MULTI-FUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF | DAVIS, BRIAN J | 1614 | DP | Non-Final OA | — | Pending | Jan 06, 2025 |
| 18989747 | LOW-DEFECT FABRICATION OF COMPOSITE MATERIALS | GOFF II, JOHN L | 1746 | §102§103§112DP | Non-Final OA | — | Pending | Dec 20, 2024 |
| 18983556 | THREE-DIMENSIONAL MACHINE KNITTING OF ELECTRONIC TEXTILE FOR ACTIVITY RECOGNITION AND BIOMECHANICAL MONITORING | MUSSER, BARBARA J | 1746 | §101§103 | Non-Final OA | — | Pending | Dec 17, 2024 |
| 18971207 | REACTION SCHEMES INVOLVING ACIDS AND BASES; REACTORS COMPRISING SPATIALLY VARYING CHEMICAL COMPOSITION GRADIENTS; AND ASSOCIATED SYSTEMS AND METHODS | LI, JUN | 1732 | §103Other | Non-Final OA | 4d overdue | Pending | Dec 06, 2024 |
| 18965935 | NOVEL TYPE VI CRISPR ENZYMES AND SYSTEMS | RYAN, DOUGLAS CHARLES | 1635 | §112 | Non-Final OA | — | Pending | Dec 02, 2024 |
| 18863758 | METHOD AND APPARATUS FOR DETERMINING ABNORMAL CARDIAC CONDITIONS NON-INVASIVELY | KRETZER, KYLE W. | 3791 | §101§102§103§112 | Non-Final OA | — | Pending | Nov 07, 2024 |
| 18862237 | BULK NANOCOMPOSITE MATERIALS AND METHODS FOR MAKING THESE | GOLDEN, CHINESSA T | 1788 | §103 | Non-Final OA | — | Pending | Nov 01, 2024 |
| 18932763 | PROGRAMMABLE NUCLEASE-PEPTIDASE COMPOSITIONS | KIEFER, DALTON EDWARD | 1652 | §102§103§112Other | Non-Final OA | — | Pending | Oct 31, 2024 |
| 18845790 | OPTICALLY ADDRESSABLE MOLECULAR-SPIN QUBIT DILUTED IN A HOST MATRIX | BROMELL, ALEXANDRIA Y | 2156 | §101 | Non-Final OA | — | Pending | Sep 10, 2024 |
| 18828425 | STRONG, MODULAR, AND PROGRAMMABLE PLATE LATTICES HAVING KIRIGAMI CORRUGATIONS | COOK, WILLIAM J | 1784 | §103§112 | Non-Final OA | — | Pending | Sep 09, 2024 |
| 18821462 | POLYANION COATED LIPID NANOPARTICLES AND METHODS OF USE THEREOF | PURDY, KYLE A | 1611 | §103 | Final Rejection | — | Pending | Aug 30, 2024 |
| 18811452 | COMBINATION THERAPIES AND METHODS OF USE THEREOF FOR TREATING CANCER | GEMBEH, SHIRLEY V | 1615 | DP | Non-Final OA | — | Pending | Aug 21, 2024 |
| 18838586 | NANO-PHASE SEPARATING NI POWDER AND THE METHODOLOGY TO IDENTIFY THEM | YANG, JIE | 1734 | §102§103§112Other | Non-Final OA | — | Pending | Aug 14, 2024 |
| 18801075 | PARTICLES WITH COVALENTLY LIPID-BOUND IMMUNOSTIMULATORY AGENTS | RICCI, CRAIG D | 1611 | §103 | Final Rejection | — | Pending | Aug 12, 2024 |
| 18798428 | Opto-Electronic Chiplets for Scalable Coherent Interconnects to Zero-Change VLSI Electronics | PAK, SUNG H | 2874 | §102§103 | Non-Final OA | — | Pending | Aug 08, 2024 |
| 18837046 | BOTTOM GARMENT WITH EMBEDDED HARNESS | LEWIS, KIM M | 3786 | §102§103 | Final Rejection | — | Pending | Aug 08, 2024 |
| 18833448 | SYSTEMS AND METHODS FOR OSMOTICALLY ASSISTED REVERSE OSMOSIS CONFIGURATIONS | MENON, KRISHNAN S | 1771 | §102§103§112 | Non-Final OA | — | Pending | Jul 26, 2024 |
| 18770880 | HEME-BINDING SMALL PEPTIDE | MARTINEZ, TARA L | 1654 | §102§103 | Non-Final OA | — | Pending | Jul 12, 2024 |
| 18727623 | AN IMPLANTABLE CLOSED-LOOP SYSTEM FOR MONITORING AND TREATMENT | DIOP, FATIMATA SAHRA | 3783 | §103 | Non-Final OA | — | Pending | Jul 09, 2024 |
| 18767197 | SUPERCONDUCTING CABLE JOINT AND RELATED TECHNIQUES | LEE, PETE T | 2847 | §102§103 | Non-Final OA | — | Pending | Jul 09, 2024 |
| 18727019 | POLYIMIDAZOLIUM-BASED CATIONIC ANTIMICROBIAL POLYMERS FOR NOVEL MASTITIS PROPHYLACTIC SOLUTIONS | HOLLOMAN, NANNETTE | 1612 | §103 | Final Rejection | — | Pending | Jul 05, 2024 |
| 18714142 | POLY(BETA-AMINO ESTER) MICROPARTICLES FOR MICRONUTRIENT FORTIFICATION | WORSHAM, JESSICA N | 1615 | §112 | Non-Final OA | — | Pending | May 29, 2024 |
| 18674715 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | RAHMANI, NILOOFAR | 1691 | §102 | Non-Final OA | — | Pending | May 24, 2024 |
| 18655491 | GEOMETRICALLY-ACCOMMODATING HEART VALVE REPLACEMENT DEVICE | GHERBI, SUZETTE JAIME J | — | §102§103Other | Non-Final OA | — | Pending | May 06, 2024 |
| 18707798 | PARTICLES CONTAINING POLLUTANT-CAPTURING MICELLES AND RELATED METHODS | NGUYEN, BOI-LIEN THI | 1779 | §102§103§112 | Non-Final OA | — | Pending | May 06, 2024 |
| 18654474 | ADDITIVE MANUFACTURING USING BONDING OF VOXELS AND RELATED SYSTEMS, DEVICES, AND ARTICLES | WIECZOREK, MICHAEL P | 1712 | §102§103 | Final Rejection | 5d overdue | Pending | May 03, 2024 |
| 18652600 | CARBON SEQUESTRATION MATERIALS AND RELATED SYSTEMS, ARTICLES, AND METHODS | MCCLAIN, STARFARI TESHAWN | 1736 | §102§103 | Non-Final OA | — | Pending | May 01, 2024 |
| 18649438 | USE OF ACIDIC ELECTROLYTE CATIONS FOR SELECTIVE ELECTROCHEMICAL CO2 AND CO CONVERSIONS TO METHANOL | WONG, EDNA | 1795 | §103§112 | Non-Final OA | — | Pending | Apr 29, 2024 |
| 18698888 | LIPID NANOPARTICLES FOR DRUG DELIVERY TO MICROGLIA IN THE BRAIN | VANHORN, ABIGAIL LOUISE | 1636 | §103§112DP | Non-Final OA | — | Pending | Apr 05, 2024 |
| 18698929 | ENGINEERED CARDIAC MUSCLE COMPOSITIONS | SINGH, ANOOP KUMAR | 1632 | §102§103§112DP | Non-Final OA | — | Pending | Apr 05, 2024 |
| 18623432 | A CARBON-EFFICIENT BICARBONATE ELECTROLYZER | RIPA, BRYAN D | 1794 | §102§103 | Non-Final OA | — | Pending | Apr 01, 2024 |
| 18623523 | Diels-Alder coupling for cycloalkane production for sustainable aviation fuel | CEPLUCH, ALYSSA L | 1772 | §103 | Final Rejection | 17d overdue | Pending | Apr 01, 2024 |
| 18604009 | Tactile Blood Pressure Imager | PARK, PATRICIA JOO YOUNG | 3798 | §103 | Final Rejection | 49d overdue | Pending | Mar 13, 2024 |
| 18689897 | ENGINEERED MUSCLE AND CENTRAL NERVOUS SYSTEM COMPOSITIONS | PYLA, EVELYN Y | 1633 | §101§102§103§112 | Non-Final OA | — | Pending | Mar 07, 2024 |
| 18690033 | A MICROBIAL ELECTROCHEMICAL TECHNOLOGY TO DETECT AND DEGRADE ORGANOPHOSPHATE PESTICIDES | FAN, WEIHUA | 1663 | §103 | Non-Final OA | 8d overdue | Pending | Mar 07, 2024 |
| 18689764 | INTERLAYERS FOR CHARGE TRANSFER-MEDIATED TRIPLET EXCITON TRANSFER FROM A SINGLET EXCITON FISSION MATERIAL TO AN INORGANIC SEMICONDUCTOR | TRINH, THANH TRUC | 1726 | §103 | Non-Final OA | — | Pending | Mar 06, 2024 |
| 18590218 | GENERATION OF QUANTUM CONTROL PULSES AND RELATED SYSTEMS | ZENG, WENWEI | 2146 | §101§103§112 | Non-Final OA | — | Pending | Feb 28, 2024 |
| 18687564 | ALTERNATIVE NANOPOROUS NETWORK MATERIALS AND PROCESSES | VO, HAI | 1788 | §102§103Other | Non-Final OA | 70d | Pending | Feb 28, 2024 |
| 18440702 | ELECTROCHEMICAL DEVICES OR SYSTEMS COMPRISING REDOX-FUNCTIONALIZED ELECTRODES AND USES THEREOF | SMITH, NICHOLAS A | 1752 | §102 | Non-Final OA | — | Pending | Feb 13, 2024 |
| 18439487 | COMPOSITIONS AND METHODS FOR MOLECULAR MEMORY STORAGE AND RETRIEVAL | OLSON, ALEXANDRA NADINE | 1684 | §102 | Non-Final OA | — | Pending | Feb 12, 2024 |
| 18438110 | MULTIPLANE NANOPHOTONIC VOXEL ENGINE | VU, PHU | 2871 | §102§103 | Non-Final OA | 46d overdue | Pending | Feb 09, 2024 |
| 18432439 | Biosensors in Human Gut Organoids | MOLOYE, TITILAYO | 1632 | §103 | Final Rejection | — | Pending | Feb 05, 2024 |
| 18294259 | DYNAMICALLY RECONFIGURABLE ARCHITECTURES FOR QUANTUM INFORMATION AND SIMULATION | STOFFA, WYATT A | — | §103§112 | Non-Final OA | — | Pending | Feb 01, 2024 |
IP Author helps IP teams respond to office actions faster with AI-generated responses, examiner analytics, and prosecution intelligence.
Start Free TrialMassachusetts Institute of Technology has 174 pending office actions as of October 2026, spread across 92 art units and 159 examiners.
Anne Marie Sabrina Wehbe has the most, with 3 of Massachusetts Institute of Technology's pending office actions.
Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.
