Technology areas: Biotechnology & Pharmaceuticals • Chemistry & Materials
48 pending office actions • 27 art units • 43 examiners • 0 of 48 (0%) have an AI response strategy ready • 66 patents granted in the last 365 days
Roche Diagnostics Operations Inc. has 48 pending office actions in Biotechnology & Pharmaceuticals. The docket spans 43 examiners and 28 art units, indicating broad distribution across examination personnel and technical groups.
SINES, BRIAN J is the busiest identified examiner, with 2 pending matters. Because concentration at the busiest examiner is limited relative to the overall docket, portfolio oversight should emphasize consistent claim positions, disclosure support, and tracking across many separate prosecution relationships.
Based on the USPTO statutory response window for each pending office action. 21 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.
Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 21 of the docket's apps have a known mailing date.
Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.
| Bucket | Cases |
|---|---|
| §101 only | 3 (6%) |
| §101 + other | 15 (31%) |
| §103 only | 9 (19%) |
| §102 only | 1 (2%) |
| §112 only | 4 (8%) |
| Double-patenting + other | 1 (2%) |
| Multi-statute (no §101) | 15 (31%) |
How the docket's pending cases split across USPTO tech-center bands.
Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.
| Examiner | Apps on this docket | Allow rate | Interview lift |
|---|---|---|---|
| SINES, BRIAN J | 2 | 80.1% | +5.2% |
| WHATLEY, BENJAMIN R | 2 | 66.7% | +68.3% |
| LANKFORD JR, LEON B | 2 | 70.0% | +31.5% |
| CHIU, MAY LEUNG | 2 | 43.3% | +26.1% |
| NGUYEN, NAM P | 2 | 54.8% | +48.7% |
| BUTLER, SARAI E | 1 | 88.2% | +10.6% |
| RODRIGUEZ, JOSEPH C | 1 | 78.4% | +15.8% |
| WANG, JING | 1 | 100.0% | +0.0% |
| HAQ, SHAFIQUL | 1 | 64.8% | +55.2% |
| BORTOLI, JONATHAN | 1 | 76.4% | +40.2% |
Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17891458 | IDENTIFICATION OF PATIENTS WITH ABNORMAL FRACTIONAL SHORTENING | MARCSISIN, ELLEN JEAN | 51d overdue |
| 18636375 | METHODS AND SYSTEMS OF SAMPLE QUALITY VERIFICATION | SANGHERA, STEVEN G.S. | 38d overdue |
| 18352183 | PROGNOSTIC VALUE OF BIOMARKERS IN PATIENTS WITH NON-SMALL CELL LUNG CANCER HAVING STABLE DISEASE | SINES, BRIAN J | 30d overdue |
| 18556849 | INFORMATION PROCESSING DEVICE FOR PROVIDING REFERENCE INFORMATION RELATING TO DIAGNOSIS OF THYROID DISEASE | HRANEK, KAREN AMANDA | 25d overdue |
| 18561621 | sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS | COUNTS, GARY W | 8d overdue |
| 17916251 | A METHOD OF ASSESSING A FEMALE'S RISK OF HAVING PCOS AS WELL AS PRODUCTS AND USES RELATING THERETO | VOLKOV, ALEXANDER ALEXANDROVIC | 4d overdue |
| 17931993 | CARRY-OVER MONITORING | HILL, GRACELYN MARKHAM | 13d |
| 17360121 | DETECTION OF BACTERIAL (MOLLICUTIES) CONTAMINATION | BERTAGNA, ANGELA MARIE | 14d |
Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 15892829 | ALKALINE PRETREATMENT OF PARVOVIRUSES FOR IMMUNOASSAYS | NGUYEN, NAM P | 26d |
| 17838568 | PARTICLE-BASED IMMUNOASSAY USING A PEGYLATED ANALYTE-SPECIFIC BINDING AGENT | NGUYEN, NAM P | 34d |
| 17814332 | SAMPLE INPUT INTERFACE | CHIU, MAY LEUNG | 54d |
| 19288563 | METHOD FOR DETECTING AND REPORTING AN OPERATION ERROR IN AN IN-VITRO DIAGNOSTIC SYSTEM AND AN IN-VITRO DIAGNOSTIC SYSTEM | BUTLER, SARAI E | — |
| 19004068 | SAFE POINT PATTERN | RODRIGUEZ, JOSEPH C | — |
| 18669957 | NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF | HAQ, SHAFIQUL | — |
| 18668368 | METHOD AND SYSTEM FOR OPERATING A LABORATORY AUTOMATION SYSTEM | BORTOLI, JONATHAN | — |
| 18642895 | ADJUSTABLE ADAPTER AND LABORATORY SYSTEM | WHATLEY, BENJAMIN R | — |
| Art Unit | Apps |
|---|---|
| 1678 | 7 |
| 1796 | 4 |
| 1797 | 4 |
| 1677 | 4 |
| 1798 | 3 |
| 3651 | 2 |
| 3684 | 2 |
| 1657 | 2 |
| 1758 | 2 |
| 2114 | 1 |
| App # | Title | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|
| 19288563 | METHOD FOR DETECTING AND REPORTING AN OPERATION ERROR IN AN IN-VITRO DIAGNOSTIC SYSTEM AND AN IN-VITRO DIAGNOSTIC SYSTEM | BUTLER, SARAI E | 2114 | §103§112Other | Non-Final OA | — | Pending | Aug 01, 2025 |
| 19004068 | SAFE POINT PATTERN | RODRIGUEZ, JOSEPH C | 3662 | §102§103§112 | Non-Final OA | — | Pending | Dec 27, 2024 |
| 18719252 | METHOD FOR CHARACTERIZATION OF A MASS SPECTROMETRY INSTRUMENT COMPRISING AT LEAST ONE MASS ANALYZING CELL | WANG, JING | 2881 | §101§103§112 | Non-Final OA | — | Pending | Jun 12, 2024 |
| 18711999 | AUTOMATIC ANALYZER | SINES, BRIAN J | 1796 | §102§103 | Non-Final OA | — | Pending | May 21, 2024 |
| 18669957 | NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF | HAQ, SHAFIQUL | 1600 | §103§112Other | Non-Final OA | — | Pending | May 21, 2024 |
| 18668368 | METHOD AND SYSTEM FOR OPERATING A LABORATORY AUTOMATION SYSTEM | BORTOLI, JONATHAN | 1797 | §101 | Non-Final OA | — | Pending | May 20, 2024 |
| 18667208 | OPTICAL SYSTEM FOR FOURIER PTYCHOGRAPHY | HUANG, WEN | 2872 | §103 | Final Rejection | — | Pending | May 17, 2024 |
| 18649151 | TRANSPORT DEVICE AND LABORATORY SAMPLE DISTRIBUTION SYSTEM | JORGENSEN, ABBY A | 3651 | §103 | Non-Final OA | 3d overdue | Pending | Apr 29, 2024 |
| 18645358 | ON-BOARD CONJUGATION | NGUYEN, BAO THUY L | 1677 | §102§103 | Non-Final OA | — | Pending | Apr 24, 2024 |
| 18642895 | ADJUSTABLE ADAPTER AND LABORATORY SYSTEM | WHATLEY, BENJAMIN R | 1798 | §102§103§112 | Non-Final OA | — | Pending | Apr 23, 2024 |
| 18636375 | METHODS AND SYSTEMS OF SAMPLE QUALITY VERIFICATION | SANGHERA, STEVEN G.S. | 3684 | §101§103§112 | Final Rejection | 38d overdue | Pending | Apr 16, 2024 |
| 18696730 | MR-PROADM MARKER PANELS FOR EARLY DETECTION OF SEPSIS | LEE, JAE W | 1759 | §101§103§112 | Non-Final OA | — | Pending | Mar 28, 2024 |
| 18692099 | CENTERING HOLDER FOR CENTERING ONE SAMPLE TUBE | WRIGHT, PATRICIA KATHRYN | 1798 | §112 | Non-Final OA | — | Pending | Mar 14, 2024 |
| 18433619 | CHIMERIC IGG-FC-BINDING LIGAND POLYPEPTIDE AND USES THEREOF FOR IGG AFFINITY PURIFICATION | SZPERKA, MICHAEL EDWARD | 1641 | §103§112 | Non-Final OA | — | Pending | Feb 06, 2024 |
| 18579561 | TRANSFER DEVICE FOR TRANSFERRING SAMPLE CONTAINERS IN A SAMPLE HANDLING SYSTEM | WHATLEY, BENJAMIN R | 1798 | §112 | Non-Final OA | — | Pending | Jan 16, 2024 |
| 18541624 | UNIVERSAL CALIBRATION FOR QUANTITATIVE MASS SPECTROMETRY | ALABI, OYELEYE A | 1797 | §101§102§103§112 | Non-Final OA | — | Pending | Dec 15, 2023 |
| 18541476 | METHOD FOR IMMUNOSENSING ON A LIPID LAYER | DUNN, MCKENZIE A | 1678 | §102§103DP | Non-Final OA | — | Pending | Dec 15, 2023 |
| 18542054 | THERMOSTABLE AFFINITY POLYPEPTIDES | HAUK TEODORO, PRICILA NMN | 1645 | §112 | Final Rejection | 57d | Pending | Dec 15, 2023 |
| 18541343 | METHOD FOR DIGITAL IMMUNOSENSING ON SINGLE MOLECULES USING LABEL IMMOBILIZATION AND AMPLIFICATION STRATEGY | IVICH, FERNANDO NMN | 1678 | §102§103§112 | Non-Final OA | — | Pending | Dec 15, 2023 |
| 18570130 | Diagnostic System, Automatic Analyzer, and Diagnostic Method | TIMILSINA, SHARAD | 2857 | §103 | Final Rejection | — | Pending | Dec 14, 2023 |
| 18561621 | sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS | COUNTS, GARY W | 1678 | §101 | Non-Final OA | 8d overdue | Pending | Nov 16, 2023 |
| 18558150 | ESM1 MARKER PANELS FOR EARLY DETECTION OF SEPSIS | LANKFORD JR, LEON B | 1657 | §103 | Non-Final OA | — | Pending | Oct 30, 2023 |
| 18558133 | IL6 MARKER PANELS FOR EARLY DETECTION OF SEPSIS | LANKFORD JR, LEON B | 1657 | §103 | Non-Final OA | — | Pending | Oct 30, 2023 |
| 18556849 | INFORMATION PROCESSING DEVICE FOR PROVIDING REFERENCE INFORMATION RELATING TO DIAGNOSIS OF THYROID DISEASE | HRANEK, KAREN AMANDA | 3684 | §101§103 | Final Rejection | 25d overdue | Pending | Oct 23, 2023 |
| 18468249 | HIGHLY WATER-SOLUBLE AND STABLE CHEMOSENSOR FOR CYSTEINE | BROOKS, CLINTON A | 1621 | §103§112 | Non-Final OA | — | Pending | Sep 15, 2023 |
| 18352183 | PROGNOSTIC VALUE OF BIOMARKERS IN PATIENTS WITH NON-SMALL CELL LUNG CANCER HAVING STABLE DISEASE | SINES, BRIAN J | 1796 | §101§102§103§112 | Final Rejection | 30d overdue | Pending | Jul 13, 2023 |
| 18339760 | AUTOMATED CLINICAL DIAGNOSTIC SYSTEM AND METHOD | WALLENHORST, MAUREEN | 1797 | §102§103§112 | Non-Final OA | — | Pending | Jun 22, 2023 |
| 18333347 | INTERFERENCE MONITORING FOR PROVIDING A VERIFIED ANALYTE MEASUREMENT | HYUN, PAUL SANG HWA | 1796 | §101§102§103§112 | Final Rejection | 33d | Pending | Jun 12, 2023 |
| 18309985 | TIMP1 AS A MARKER FOR CHOLANGIOCARCINOMA | DENT, ALANA HARRIS | 1643 | §102 | Final Rejection | 20d | Pending | May 01, 2023 |
| 18178595 | INTELLIGENT USER GUIDANCE FOR LABORATORY ISSUE RESOLUTION | ANDERSON, FOLASHADE | 3623 | §101 | Final Rejection | 36d | Pending | Mar 06, 2023 |
| 18017073 | GDF-15 FOR PREDICTING THE DISEASE SEVERITY OF A PATIENT WITH COVID-19 | ZOU, NIANXIANG | 1671 | §101§103 | Final Rejection | 61d | Pending | Jan 19, 2023 |
| 17990903 | REAGENT FOR MASS SPECTROMETRY | ADAMS, MICHELLE | 1797 | §102§112 | Non-Final OA | — | Pending | Nov 21, 2022 |
| 17916251 | A METHOD OF ASSESSING A FEMALE'S RISK OF HAVING PCOS AS WELL AS PRODUCTS AND USES RELATING THERETO | VOLKOV, ALEXANDER ALEXANDROVIC | 1677 | §101§103§112 | Final Rejection | 4d overdue | Pending | Sep 30, 2022 |
| 17931993 | CARRY-OVER MONITORING | HILL, GRACELYN MARKHAM | 1685 | §101§103 | Non-Final OA | 13d | Pending | Sep 14, 2022 |
| 17893574 | CLINICAL DECISION SUPPORT ON CLINICAL ANALYZER | HIGGS, STELLA EUN | 3681 | §103 | Final Rejection | — | Pending | Aug 23, 2022 |
| 17891458 | IDENTIFICATION OF PATIENTS WITH ABNORMAL FRACTIONAL SHORTENING | MARCSISIN, ELLEN JEAN | 1677 | §101§103§112 | Final Rejection | 51d overdue | Pending | Aug 19, 2022 |
| 17814332 | SAMPLE INPUT INTERFACE | CHIU, MAY LEUNG | 1758 | §102§103§112 | Final Rejection | 54d | Pending | Jul 22, 2022 |
| 17838568 | PARTICLE-BASED IMMUNOASSAY USING A PEGYLATED ANALYTE-SPECIFIC BINDING AGENT | NGUYEN, NAM P | 1678 | §103 | Final Rejection | 34d | Pending | Jun 13, 2022 |
| 17664230 | METHOD AND DISTRIBUTION SYSTEM TO MOVE CARRIERS ON A TRANSPORT PLANE | CUMBESS, YOLANDA RENEE | 3651 | §102§103§112 | Final Rejection | 36d | Pending | May 20, 2022 |
| 17660299 | PREANALYTIC SYSTEM FOR PREPARING A LABORATORY SAMPLE CONTAINER | CHIU, MAY LEUNG | 1758 | §103 | Final Rejection | — | Pending | Apr 22, 2022 |
| 17575202 | S100A12 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ENDOMETRIOSIS | MONTGOMERY, ANN Y | 1678 | §101§103§112 | Final Rejection | 28d | Pending | Jan 13, 2022 |
| 17447844 | METHOD FOR DETERMINING AT LEAST ONE STATE OF AT LEAST ONE CAVITY OF A TRANSPORT INTERFACE CONFIGURED FOR TRANSPORTING SAMPLE TUBES | SKIBINSKY, ANNA | 1635 | §101§103 | Non-Final OA | 16d | Pending | Sep 16, 2021 |
| 17444397 | SAMPLE CONTAINER TRANSPORT SYSTEM | LE, AUSTIN Q | 1796 | §103§112 | Non-Final OA | — | Pending | Aug 04, 2021 |
| 17360121 | DETECTION OF BACTERIAL (MOLLICUTIES) CONTAMINATION | BERTAGNA, ANGELA MARIE | 1681 | §101§103 | Final Rejection | 14d | Pending | Jun 28, 2021 |
| 17150504 | METHODS OF IDENTIFYING AN INDIVIDUAL AS HAVING OR BEING AT RISK OF DEVELOPING AN AMYLOID-POSITIVE DEMENTIA BASED ON MARKER MOLECULES AND RELATED USES | RAMADAN, OMAR | 1678 | §101§102§103§112 | Final Rejection | — | Pending | Jan 15, 2021 |
| 16008281 | FKBP DOMAIN WITH TRANSGLUTAMINASE RECOGNITION SITE | DABKOWSKI, ERINNE R | 1654 | §112 | Final Rejection | 42d overdue | Pending | Jun 14, 2018 |
| 15965748 | METHODS AND SYSTEMS FOR ANALYZING TISSUE QUALITY USING MID-INFRARED SPECTROSCOPY | KIRWIN, STEFANIE JOHANNA | 1677 | §103Other | Non-Final OA | — | Pending | Apr 27, 2018 |
| 15892829 | ALKALINE PRETREATMENT OF PARVOVIRUSES FOR IMMUNOASSAYS | NGUYEN, NAM P | 1678 | §103§112 | Non-Final OA | 26d | Pending | Feb 09, 2018 |
IP Author helps IP teams respond to office actions faster with AI-generated responses, examiner analytics, and prosecution intelligence.
Start Free TrialRoche Diagnostics Operations Inc. has 48 pending office actions as of October 2026, spread across 27 art units and 43 examiners.
Brian J Sines has the most, with 2 of Roche Diagnostics Operations Inc.'s pending office actions.
Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.
