Prosecution Insights
Last updated: October 04, 2026

Double Helix Law

Technology area: Biotechnology & Pharmaceuticals

8 pending office actions • 4 clients • 8 examiners • 3 art units • 0 of 8 (0%) have an AI response strategy ready • 4 patents granted in the last 365 days

Analysis

Double Helix Law is currently managing 5 pending office actions. These applications are situated within the Biotechnology & Pharmaceuticals technology area. The firm's career history includes 164 applications, which provides the context for their current work. The 5 pending office actions represent the current active workload for this firm in the biotech sector.

The firm reports a resolved allowance rate of 44.83 percent. Reaching an allowance typically involves an average of 2.69 office actions. These 5 pending office actions are part of a prosecution practice focused on pharmaceutical technologies. The 44.83 percent allowance rate and 2.69 average office actions per allowance provide a statistical framework for understanding the firm's performance. Practitioners can use the 2.69 average office actions per allowance to estimate the likely progression of these active matters. The 44.83 percent allowance rate serves as a performance metric for the Biotechnology & Pharmaceuticals field.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Quality Metrics (n=164 apps, methodology: how we score firms)

44.8%
Allowance Rate
n=164
+0.04σ
Allowance Rate (norm)
n=164
2.7
OAs to Allowance
n=26
-0.54σ
OAs to Allow (norm)
n=26
1054 days
Time to Allowance
n=26
+29.5pp
Interview Lift
n=164
25.9%
RCE Rate
n=164
0.0%
Appeal Rate
n=164

Rejection Performance (% of received rejections ultimately overcome)

—
§101 Overcome
n=3 (min 20)
—
§102 Overcome
n=14 (min 20)
25.5%
§103 Overcome
n=47
33.3%
§112 Overcome
n=39

Specialization & Scale

A61K, C12N, A61P
Top CPC Subclasses
71%
Top-3 CPC Share
n=164
1
Practitioners
n=164
164.0
Apps / Practitioner
n=164

Portfolio Summary

8
Total Pending OAs
3
Non-Final OAs
2
Final Rejections
3
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 3 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

2
Overdue
0
Due this week
0
Due this month
1
Due in next 60 days
0
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 3 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (2)Due ≤ 60 days (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

2
Hard (25%)
2
Medium (25%)
4
Easy (50%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§103 only2 (25%)
§112 only4 (50%)
Multi-statute (no §101)2 (25%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

6
Life Sciences
75% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
2
Business / Other
25% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

80 h
Manual time on pending OAs
16 h
Time saved (low, 20%)
28 h
Time saved (mid, 35%)
0.7 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
CONIGLIO, AUDREA JUNE BUCKLEY 1 52.9% +21.1%
MATALKAH, FATIMAH KHALAF 1 54.8% +28.6%
KASAYAN, KATRIEL BARCELLANO 1 25.0% +0.0%
SPENCE, JENNIFER SUZANNE 1 66.9% +46.0%
JOHNSON, ALLISON MARIE 1 40.9% +53.3%
TINSLEY, BRENDAN THOMAS 1 58.7% +73.9%
BURKHART, MICHAEL D 1 62.3% +11.7%
NICOL, ALEXANDER W 1 42.9% +43.1%

Hard Cases (2)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 2 ordered by deadline are shown.

App #TitleExaminerDue in
18341700 MATERIALS AND METHODS FOR PRODUCING BLOOD PRODUCTS KASAYAN, KATRIEL BARCELLANO 54d
18942968 TRANSDERMAL DELIVERY FORMULATIONS AND METHODS FOR THE MANUFACTURE THEREOF CONIGLIO, AUDREA JUNE BUCKLEY —

Interview Candidates (7)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 7 ordered by deadline are shown.

App #TitleExaminerDue in
17639281 METHODS AND COMPOSITIONS FOR THE MODIFICATION AND DELIVERY OF LYMPHOCYTES TINSLEY, BRENDAN THOMAS 134d overdue
17272631 METHODS AND COMPOSITIONS FOR GENETICALLY MODIFYING LYMPHOCYTES IN BLOOD OR IN ENRICHED PBMCS BURKHART, MICHAEL D 30d overdue
18942968 TRANSDERMAL DELIVERY FORMULATIONS AND METHODS FOR THE MANUFACTURE THEREOF CONIGLIO, AUDREA JUNE BUCKLEY —
18653905 METHODS FOR CONTROLLING BLEEDING IN A SUBJECT AFFLICTED WITH HERMANSKY PUDLAK SYNDROME USING PLATELET DERIVATIVE COMPOSITIONS MATALKAH, FATIMAH KHALAF —
17905649 METHODS AND COMPOSITIONS FOR THE DELIVERY OF MODIFIED LYMPHOCYTE AGGREGATES SPENCE, JENNIFER SUZANNE —
17684405 METHODS AND COMPOSITIONS FOR THE DELIVERY OF MODIFIED LYMPHOCYTES AND/OR RETROVIRAL PARTICLES JOHNSON, ALLISON MARIE —
16478377 METHODS OF TRANSDUCING AND EXPANDING IMMUNE CELLS AND USES THEREOF NICOL, ALEXANDER W —

Client Portfolio (4 clients)

Client (Assignee)Pending OAs
Exuma Biotech 4
Cellphire 2
Lifeactive, Inc. 1
Exuma Biotech Corp. 1

Top Art Units

Art UnitApps
16343
16382
16331

Pending Office Actions

App #TitleClientExaminerArt UnitStatutesStatusDue inAIFiled
18942968 TRANSDERMAL DELIVERY FORMULATIONS AND METHODS FOR THE MANUFACTURE THEREOF Lifeactive, Inc. CONIGLIO, AUDREA JUNE BUCKLEY §103§112 Non-Final OA — Pending Nov 11, 2024
18653905 METHODS FOR CONTROLLING BLEEDING IN A SUBJECT AFFLICTED WITH HERMANSKY PUDLAK SYNDROME USING PLATELET DERIVATIVE COMPOSITIONS Cellphire, Inc. MATALKAH, FATIMAH KHALAF §103 Non-Final OA — Pending May 02, 2024
18341700 MATERIALS AND METHODS FOR PRODUCING BLOOD PRODUCTS Cellphire, Inc. KASAYAN, KATRIEL BARCELLANO 1634 §103§112Other Non-Final OA 54d Pending Jun 26, 2023
17905649 METHODS AND COMPOSITIONS FOR THE DELIVERY OF MODIFIED LYMPHOCYTE AGGREGATES Exuma Biotech Corp. SPENCE, JENNIFER SUZANNE 1633 §103 Non-Final OA — Pending Sep 05, 2022
17684405 METHODS AND COMPOSITIONS FOR THE DELIVERY OF MODIFIED LYMPHOCYTES AND/OR RETROVIRAL PARTICLES Exuma Biotech Corp. JOHNSON, ALLISON MARIE 1638 §112Other Final Rejection — Pending Mar 01, 2022
17639281 METHODS AND COMPOSITIONS FOR THE MODIFICATION AND DELIVERY OF LYMPHOCYTES Exuma Biotech Corp. TINSLEY, BRENDAN THOMAS 1634 §112 Non-Final OA 134d overdue Pending Feb 28, 2022
17272631 METHODS AND COMPOSITIONS FOR GENETICALLY MODIFYING LYMPHOCYTES IN BLOOD OR IN ENRICHED PBMCS Exuma Biotech Corp. BURKHART, MICHAEL D 1638 §112 Final Rejection 30d overdue Pending Mar 01, 2021
16478377 METHODS OF TRANSDUCING AND EXPANDING IMMUNE CELLS AND USES THEREOF Exuma Biotech Corp. NICOL, ALEXANDER W 1634 §112Other Non-Final OA — Pending Jul 16, 2019

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