Prosecution Insights
Last updated: October 25, 2026

James J Graber, USPTO Patent Examiner

Listed by the USPTO as GRABER, JAMES J

Tech Center 1600 • Art Units: 1631 1633

This examiner grants 46% of resolved cases

Analysis

GRABER, JAMES J is a USPTO patent examiner in Tech Center 1600 and art unit 1631. The profile covers 200 resolved cases, with an allowance rate of 46.5% and a median of 1389 days to allowance. Interview participation shows a lift of 57.6%, indicating a strong positive association with allowance in the recorded matters.

The leading companies are Duke University, St. Jude Children's Research Hospital Inc., and Editas Medicine Inc. The listed firms are POLSINELLI and DUKE UNIVERSITY, THOMAS | HORSTEMEYER, LLP, and AMSTER, ROTHSTEIN & EBENSTEIN LLP. For biotechnology and medical matters, practitioners may find it useful to pair a focused written response with an interview plan, then examine the specific claim features that preceded allowance.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Performance Statistics

46.5%
Allow Rate
-13.5% vs TC avg
245
Total Applications
+57.6%
Interview Lift
1389
Avg Prosecution Days
Based on 200 resolved cases, 2023–2026

Rejection Statute Breakdown

5.3%
§101 Eligibility
16.5%
§102 Novelty
35.3%
§103 Obviousness
29.6%
§112 Clarity

Currently Pending Office Actions

App #TitleStatusAssignee
18890553 Treatment of Mitochondrial Disease with Autologous Expanded Mesenchymal Stem Cell Therapy Non-Final OA Individual inventor
18558859 UNIVERSAL RETARGETING OF ONCOLYTIC HSV Non-Final OA Janssen Biotech, Inc.
17430382 MODIFIED NATURAL KILLER (NK) CELLS FOR IMMUNOTHERAPY Final Rejection Editas Medicine, Inc.
18289881 3D HUMAN DISTAL LUNG ORGANOIDS CONTAINING EPITHELIAL, IMMUNE AND MESENCHYMAL COMPONENTS Final Rejection The Board of Trustees of the Leland Stanford Junior University
18832458 RECOMBINANT OPTIMIZED MECP2 CASSETTES AND METHODS FOR TREATING RETT SYNDROME AND RELATED DISORDERS Non-Final OA THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
18721743 NON-HUMAN ANIMALS COMPRISING HUMANIZED ACE2 AND TMPRSS LOCI Non-Final OA Regeneron Pharmaceuticals, Inc.
18568091 METHODS FOR ENGINEERING AND USE OF CILIATED ORGANOIDS HAVING NATIVE-LIKE, APICAL-OUT POLARITY Non-Final OA Carnegie Mellon University
18294033 CULTURED ADIPOSE TISSUE Non-Final OA Trustees of Tufts College
18248193 PRODUCTION OF MEGAKARYOCYTES AND PLATELETS IN A CO-CULTURE SYSTEM Final Rejection BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
17580219 INCREASING GENOME STABILITY AND REPROGRAMMING EFFICIENCY OF INDUCED PLURIPOTENT STEM CELLS Final Rejection THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
17911018 COMPOSITION FOR INDUCING APOPTOSIS OF CELLS HAVING GENOMIC SEQUENCE VARIATION AND METHOD FOR INDUCING APOPTOSIS OF CELLS BY USING COMPOSITION Non-Final OA UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
18840303 MULTIPLEXED REPRESSION OF IMMUNOSUPPRESSIVE GENES Non-Final OA Yale University
18707756 STEM CELL DIFFERENTIATION AND CHEMICAL COMPOUNDS Non-Final OA VERTEX PHARMACEUTICALS INCORPORATED
18680912 Methods of Producing Astrocytes or Promoting Astrocyte Development and Cell Culture Compositions Related Thereto Non-Final OA Emory University
18547332 Compositions For and Methods of Improving Gene Therapy Non-Final OA Duke University
17637760 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL PAIN AND ITCH Final Rejection DUKE UNIVERSITY
17783040 Method for Preparing CD7-Negative, CD3-Positive T Cells Non-Final OA ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
17258533 USE OF IL-12 TO ALTER EPIGENETIC EFFECTOR PROGRAMS IN CD8 T CELLS Final Rejection St. Jude Children's Research Hospital
18909327 METHODS FOR TREATING NEUROLOGICAL DISEASES Non-Final OA Cytora Ltd.
18854936 ENZYME-FREE PROCESSES TO PRODUCE HYDROGELS Non-Final OA TISSUELABS PESQUISA E DESENVOLVIMENTO LTDA
18567094 COMPOSITIONS AND METHODS FOR ISLET CELL TRANSPLANTS Non-Final OA City of Hope
18704322 METHOD FOR PRODUCING ORGANISM, AND METHOD FOR PROMOTING DIFFERENTIATION OF HUMAN ADIPOSE-DERIVED STEM CELLS INTO VASCULAR ENDOTHELIAL CELLS Final Rejection KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
18732209 USE OF miR-34b IN REGULATING LIPID METABOLISM OF SHANDONG BLACK CATTLE Non-Final OA Qingdao Agricultural University
18682797 GENETICALLY MODIFIED CELLS FOR ALLOGENEIC CELL THERAPY TO REDUCE INSTANT BLOOD MEDIATED INFLAMMATORY REACTIONS Non-Final OA Sana Biotechnology, Inc.
18715599 METHODS FOR CELL CULTURING Non-Final OA Orbillion Bio, Inc.
18686638 METHOD FOR PRODUCING INNER EAR STRIA VASCULARIS MARGINAL CELLS, CHEMICAL AGENT ASSESSMENT METHOD, AND CELL CULTURE FOR ASSESSING CHEMICAL AGENT Final Rejection THE KITASATO INSTITUTE
15780542 SCALABLE METHODS FOR PRODUCING RECOMBINANT ADENO-ASSOCIATED VIRAL (AAV) VECTOR IN SERUM-FREE SUSPENSION CELL CULTURE SYSTEM SUITABLE FOR CLINICAL USE Final Rejection SPARK THERAPEUTICS, INC.
18441393 ENGRAFTABLE CELL-BASED IMMUNOTHERAPY FOR LONG-TERM DELIVERY OF THERAPEUTIC PROTEINS Non-Final OA Seattle Children's Hospital (dba Seattle Children's Research Institute)
18439283 ANIMAL MODEL OF CD19 CHIMERIC ANTIGEN RECEPTOR (CAR)-T CELL THERAPY FOR LEUKEMIA COMPLICATED BY CYTOKINE RELEASE SYNDROME (CRS), AND PREPARATION METHOD AND USE THEREOF Non-Final OA UNION HOSPITAL TONGJI MEDICAL COLLEGE HUST
17745314 MRNA FUNCTIONALIZATION METHOD Non-Final OA KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

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Frequently Asked Questions

What is examiner James J Graber's allowance rate?

46.5% of resolved applications examined by James J Graber were allowed (200 resolved cases), compared with 28.4% across Art Unit 1631 over the last five years.

Does an interview help with examiner James J Graber?

This examiner's interview lift is +57.6 percentage points: the difference in allowance rate between resolved applications that had an examiner interview and those that did not.

How long does examiner James J Graber take to allow a patent?

Applications allowed by James J Graber took 1,389 days on average from filing to allowance.

Which art unit does examiner James J Graber work in?

James J Graber examines applications in Art Unit 1631 in Tech Center 1600 (Biotechnology & Pharmaceuticals).

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