Prosecution Insights
Last updated: October 02, 2026

Examiner: SPANGLER, JOSEPH RANKIN

Tech Center 1600 • Art Units: 1656

This examiner grants 41% of resolved cases

Analysis

Joseph Rankin Spangler handles cases in Tech Center 1600 and Art Unit 1656, where he has 67 resolved cases. The allowance rate of 40.3% indicates a rigorous examination process. This is paired with a median days to allowance of 1318, suggesting that reaching a grant requires both persistence and a significant time investment. The 67 resolved cases show a consistent pattern of detailed scrutiny and extended timelines.

The interview lift of 68.8% is exceptionally high, representing one of the most impactful tools available to practitioners in this docket. While the base allowance rate is only 40.3%, the 68.8% lift suggests that an interview greatly improves the likelihood of a positive outcome. For the 67 resolved cases under review, the 1318 days to allowance can be navigated more effectively through direct consultation. Practitioners should prioritize interviews early in the process to mitigate the challenges reflected in the 40.3% allowance rate. Direct communication appears to be the most successful strategy for overcoming the hurdles present in Art Unit 1656, potentially saving time and resources.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Performance Statistics

41.2%
Allow Rate
-18.8% vs TC avg
107
Total Applications
+69.5%
Interview Lift
1324
Avg Prosecution Days
Based on 68 resolved cases, 2023–2026

Rejection Statute Breakdown

11.0%
§101 Eligibility
12.5%
§102 Novelty
36.1%
§103 Obviousness
23.2%
§112 Clarity

Currently Pending Office Actions

App #TitleStatusAssignee
17514264 Fibrosis Assay Final Rejection Georgia Tech Research Corporation
17615853 METHOD FOR ANALYZING MICROBIAL FLORA Final Rejection NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
18032105 WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES Final Rejection President and Fellows of Harvard College
18197579 BIOANALYSIS OF THERAPEUTIC ANTIBODIES AND RELATED PRODUCTS USING IMMUNOPRECIPITATION AND NATIVE SEC-PCD-MS DETECTION Non-Final OA Regeneron Pharmaceuticals, Inc.
17609841 GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYHEXANEDIOIC ACID, (E)-HEX-2-ENEDIOIC ACID AND/OR HEXANEDIOIC ACID, AND PRODUCTION METHOD FOR SAID CHEMICALS Non-Final OA TORAY INDUSTRIES, INC.
17609964 GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYHEXANEDIOIC ACID, (E)-HEX-2-ENEDIOIC ACID AND/OR HEXANEDIOIC ACID, AND PRODUCTION METHOD FOR SAID CHEMICALS Non-Final OA TORAY INDUSTRIES, INC.
18518641 NOVEL DUNALIELLA SALINA AND USES THEREOF Non-Final OA IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)
17299180 Cells with reduced inhibitor production and methods of use thereof Final Rejection PFIZER INC.
17602367 METHOD AND APPARATUS FOR PURIFYING BLOOD Final Rejection B. Braun Avitum AG
18558943 SEQUENCE-DEFINED POLYMERS WITH ONE OR MORE AZIDES, METHODS OF MAKING, AND METHODS OF USE THEREOF Non-Final OA Yale University
17415344 ASPARAGINASE-INDUCED GLUTAMINE DEPLETION COMBINED WITH BCL-2 INHIBITION FOR TREATMENT OF HEMATOLOGIC AND SOLID CANCERS Final Rejection UNIVERSITY OF MARYLAND, BALTIMORE
17624764 METHODS FOR DIAGNOSING MULTIPLE SCLEROSIS Final Rejection OXFORD UNIVERSITY INNOVATION LIMITED
17634909 TEXTURING L. LACTIS WITH UNIQUE EPS GENE CLUSTERS Final Rejection Chr. Hansen A/S
16769964 SPRAY-DRIED SIALYLLACTOSE Final Rejection Chr. Hansen A/S
18286324 ENZYMES, MICRO-ORGANISMS AND USES THEREOF, AND A METHOD OF DEGRADING A POLYOLEFIN Final Rejection TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
18287386 REAGENT COMPOSITION AND KIT Final Rejection DENKA COMPANY LIMITED
18720218 NEXT GENERATION TRANSPOSOSOMES Non-Final OA The United States of America, as Represented by The Secretary, Department of Health and Human Servic
17830227 METHODS AND SYSTEMS FOR PREPARING THERAPEUTIC SOLUTIONS FOR POLYMICROBIAL INFECTIONS Non-Final OA CAP Diagnostics, LLC dba Pathnostics
17418505 BIOSYNTHETIC METHODS AND SYSTEMS FOR PRODUCING MONOSACCHARIDES Final Rejection Cemvita Factory, Inc.

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