Prosecution Insights
Last updated: October 25, 2026

Hamilton, Brook, Smith & Reynolds, P.C.

Technology area: Biotechnology & Pharmaceuticals

177 pending office actions • 104 clients • 171 examiners • 130 art units • 0 of 177 (0%) have an AI response strategy ready

Analysis

HAMILTON, BROOK, SMITH & REYNOLDS, P.C. works in Biotechnology & Pharmaceuticals, with 12,534 career applications and 177 pending office actions. Its resolved allowance rate is 77.52%, and the average number of office actions per allowance is 3.85.

The 177 pending office actions indicate substantial active prosecution within the application record. The 77.52% resolved allowance rate and 3.85 action average give practitioners distinct measures of outcome and prosecution effort for this biotechnology portfolio.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Quality Metrics (n=12534 apps, methodology: how we score firms)

77.5%
Allowance Rate
n=12534
+0.54σ
Allowance Rate (norm)
n=12534
3.8
OAs to Allowance
n=6200
+0.17σ
OAs to Allow (norm)
n=6200
1183 days
Time to Allowance
n=6200
+14.7pp
Interview Lift
n=12534
31.2%
RCE Rate
n=12534
1.4%
Appeal Rate
n=12534

Rejection Performance (% of received rejections ultimately overcome)

81.8%
§101 Overcome
n=1250
78.4%
§102 Overcome
n=2611
79.2%
§103 Overcome
n=4240
80.1%
§112 Overcome
n=2937

Specialization & Scale

A61K, G06F, A61P
Top CPC Subclasses
19%
Top-3 CPC Share
n=12534
28
Practitioners
n=12534
447.6
Apps / Practitioner
n=12534

Portfolio Summary

177
Total Pending OAs
103
Non-Final OAs
66
Final Rejections
8
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 53 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

31
Overdue
3
Due this week
11
Due this month
7
Due in next 60 days
1
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 53 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (31)Due ≤ 7 days (3)Due ≤ 30 days (11)Due ≤ 60 days (7)Due later (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

90
Hard (51%)
75
Medium (42%)
10
Easy (6%)
2
Unknown (1%)

Rejection Statute Mix

BucketCases
§101 only6 (3%)
§101 + other21 (12%)
§103 only56 (32%)
§102 only10 (6%)
§112 only9 (5%)
Double-patenting only1 (1%)
Double-patenting + other9 (5%)
Multi-statute (no §101)63 (36%)
No statute on record2 (1%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

88
Life Sciences
50% of docket
34
Information Tech
19% of docket
8
Communications
5% of docket
14
Semiconductors
8% of docket
31
Mechanical / Eng
18% of docket
2
Business / Other
1% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

1,770 h
Manual time on pending OAs
354 h
Time saved (low, 20%)
620 h
Time saved (mid, 35%)
15.5 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
SANG, HONG 3 54.9% +62.8%
HENRY, MATTHEW D 2 29.7% +19.7%
SIMMONS, CHRIS E 2 34.2% +19.6%
WOZNICKI, JACQUELINE 2 49.8% +26.2%
LAM, YEE F 2 77.2% +21.1%
DUFFY, BRADLEY 1 54.4% +46.0%
KHAN, MOEEN 1 69.0% +59.9%
HRANEK, KAREN AMANDA 1 34.7% +40.4%
WORJLOH, JALATEE 1 65.0% +36.9%
BECK, LERON 1 80.3% +10.8%

Hard Cases (90)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17730897 Performing A Deformation-Based Physics Simulation HAO, YI 190d overdue
18328682 ADJUNCTIVE THERAPY FOR DEPRESSION CHONG, YONG SOO 121d overdue
17758847 Inhibitors of Glucose-6-phosphate Dehydrogenase and Uses Thereof ANDERSON, REBECCA L 107d overdue
17780961 BIOMASS-BASED SOLID COMPOSITE ELECTROLYTES FOR BATTERIES NGUYEN, KEVIN NMN 56d overdue
18753908 Method And Apparatus For Wireless Communications ARMSTRONG, JONATHAN D 36d overdue
17594150 System and Method for Improving a Processing System using Learning Systems KNIGHT, PAUL M 24d overdue
18608851 Sensor, System and Method for Detecting or Sensing Moisture or Wetness of an Article FERDOUS, ZANNATUL 19d overdue
17820662 SOLID-STATE ELECTROLYTE, CATHODE ELECTRODE, AND METHODS OF MAKING SAME FOR SULFIDE-BASED ALL-SOLID-STATE-BATTERIES VAN KIRK, DUSTIN KENWOOD 18d overdue

Interview Candidates (16)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
16920107 NETWORK SWITCHING WITH CO-RESIDENT DATA-PLANE AND NETWORK INTERFACE CONTROLLERS LAM, YEE F 100d overdue
18747113 System and Method for Optimizing Sustainability for a Real-World System HENRY, MATTHEW D 17d overdue
18175345 Methods of Treating High Risk Multiple Myeloma SANG, HONG 10d overdue
16797301 Methods of Treating Newly Diagnosed Multiple Myeloma with a Combination of An Antibody that Specifically Binds CD38, Lenalidomide and Dexamethasone SANG, HONG 4d overdue
18298855 Automated Evaluation of Refinery and Petrochemical Feedstocks Using a Combination of Historical Market Prices, Machine Learning, and Algebraic Planning Model Information HENRY, MATTHEW D 54d
19658174 Subcutaneous Formulations Of Anti-CD38 Antibodies And Their Uses DUFFY, BRADLEY —
19418900 METHODS OF TREATING HIGH RISK MULTIPLE MYELOMA SANG, HONG —
19415519 Authenticating a user KHAN, MOEEN —

Client Portfolio (104 clients)

View all 104 →

Top Art Units

Art UnitApps
16464
26743
37743
16213
16193
37913
16533
16313
16432
36842

Pending Office Actions

App #TitleClientExaminerArt UnitStatutesStatusDue inAIFiled
19658174 Subcutaneous Formulations Of Anti-CD38 Antibodies And Their Uses Janssen Biotech, Inc. DUFFY, BRADLEY 1643 Other Non-Final OA — Pending Apr 24, 2026
19418900 METHODS OF TREATING HIGH RISK MULTIPLE MYELOMA Janssen Biotech, Inc. SANG, HONG 1646 §102§103§112 Final Rejection — Pending Dec 12, 2025
19415519 Authenticating a user Eckoh UK Limited KHAN, MOEEN 2436 §103 Non-Final OA — Pending Dec 10, 2025
19331792 Methods And Systems For Assessing Cumulative Ergonomic Risk Dassault Systems Americas Corp. HRANEK, KAREN AMANDA 3684 §101§103 Non-Final OA — Pending Sep 17, 2025
19276914 Systems and Methods for Computationally Evolving Digital Assets and Controlling Digital Asset Transactions Frontage Road Holdings, LLC WORJLOH, JALATEE 3697 §101§103 Non-Final OA — Pending Jul 22, 2025
19126030 CALIBRATION OF A CAMERA COORDINATE SYSTEM Smart Eye AB BECK, LERON 2487 §103§112 Non-Final OA — Pending Apr 30, 2025
19182761 Automatic Discovery and Reporting of Streaming Content of Interest and Connection of User to Same Openexchange, Inc. JEAN GILLES, JUDE 2459 §112DP Non-Final OA — Pending Apr 18, 2025
19088128 Pharmaceutical Formulation Klaria Pharma Holding AB HOLLOMAN, NANNETTE 1612 §102§103§112DP Non-Final OA — Pending Mar 24, 2025
19073852 Cupholder and Phone Mounting System for a Golf Bag Gramse Engineering LLC WOOD, KIMBERLY T 3631 §103 Non-Final OA — Pending Mar 07, 2025
19073578 METHOD AND SYSTEM FOR COMMUNICATION CONTROL Granite Telecommunications, LLC BEZUAYEHU, SOLOMON G 2674 §103Other Non-Final OA — Pending Mar 07, 2025
19073801 Scalable Offloading of Computer Vision Processing Tasks Politecnico Di Torino HOSSAIN, KAMAL M 2444 §102 Non-Final OA — Pending Mar 07, 2025
19108603 MWW-STRUCTURED MOLECULAR SIEVE, PREPARATION METHOD THEREFOR AND USE THEREOF Petrochina Company Limited VASISTH, VISHAL V 1771 §103§112DP Non-Final OA — Pending Mar 04, 2025
19106975 IMAGE PROCESSING DEVICE AND METHOD USING ARTIFICIAL NEURAL NETWORK MODEL Korea Advanced Institute Of Science And Technology MAUPIN, HUGH H 2884 §102 Non-Final OA — Pending Feb 26, 2025
19061060 Systems and Methods for Determining Properties of a Wellbore DASSAULT SYSTEMES N'DURE, AMIE MERCEDES 3645 §103 Non-Final OA — Pending Feb 24, 2025
19103545 CIRCUIT CONTROL METHOD AND UNIT, AND APPARATUS Ace Power And Technology Co., Ltd. MOODY, KYLE J 2838 §102 Non-Final OA — Pending Feb 12, 2025
19043414 MODULAR HYDROPOWER SYSTEMS AND METHODS WITH PUMPED STORAGE W.L. French Hydropower Holdings LLC NGUYEN, VIET P 2834 §103 Final Rejection 87d overdue Pending Feb 01, 2025
19016629 Series Enabled Multi-Material Extrusion Technology Mosaic Manufacturing Ltd. KIM, YUNJU 1742 §102§103 Final Rejection — Pending Jan 10, 2025
18986503 RNA Synthesis-Phosphoramidites for Synthetic RNA in the Reverse Direction, and Application in Convenient Introduction of Ligands, Chromophores and Modifications of Synthetic RNA at the 3'-End Chemgenes Corporation DIAMOND, ALAN D 3991 §112Other Non-Final OA — Pending Dec 18, 2024
18983952 Medication Adherence Device And Coordinated Care Platform Watchrx, Inc. BLANCHETTE, JOSHUA B 3684 §101§103 Non-Final OA 40d Pending Dec 17, 2024
18961377 MODULAR PRECAST PUMPED STORAGE HYDRO SYSTEM FOR POWER GENERATION W.L. French Hydropower Holdings LLC FIORELLO, BENJAMIN F 3678 §102§103 Non-Final OA — Pending Nov 26, 2024
18869129 METHODS AND SYSTEMS FOR IMAGING INTERACTIONS BETWEEN PARTICLES AND FRAGMENTS UNIVERSITY OF MASSACHUSETTS NAH, JONGBONG 2674 §103 Non-Final OA — Pending Nov 25, 2024
18869143 Systems and Methods for Endoluminal Tracking with Therapeutic Delivery Sensing Frond Medical Inc. KIM, KAITLYN EUNJI 3797 §102§103 Non-Final OA — Pending Nov 25, 2024
18933478 System and Method for Manipulating Deformable Objects Northeastern University OH, HARRY Y 3657 §103§112 Final Rejection 22d Pending Oct 31, 2024
18932157 Generating, interpreting and adapting a 3D learning environment using ANNs Labster Aps SAINT-VIL, EDDY 3715 §101§103 Non-Final OA — Pending Oct 30, 2024
18923237 SYSTEMS AND METHODS FOR NETWORK CONTROL Granite Telecommunications, LLC ALRIYASHI, ABDULKADER MOHAMED 2447 §103Other Non-Final OA 37d overdue Pending Oct 22, 2024
18856983 PROCESS AND DEVICE FOR ASSEMBLY OF VAN DER WAALS HETEROSTRUCTURES The University of Manchester SWIER, WAYNE K. 1748 §102§103 Non-Final OA — Pending Oct 15, 2024
18909800 Excitation source system and first device for managing backscatter interference Koninklijke Kpn N.V. KUNTZ, CURTIS A 2646 §103§112 Non-Final OA — Pending Oct 08, 2024
18908040 METHOD AND SYSTEM FOR PERCEIVING TRAFFIC ROAD ENVIRONMENT BASED ON GRAPH REPRESENTATION FOR AUTONOMOUS DRIVING Korea Advanced Institute Of Science And Technology PARK, EDWARD 2675 §102§103 Non-Final OA — Pending Oct 07, 2024
18905753 DELIVERY SYSTEM FOR PLACEMENT OF ENDOLUMINAL DEVICES Frond Medical Inc. COCHRAN, KARI LEE 3774 §102§103 Non-Final OA — Pending Oct 03, 2024
18851207 Wearable Holding Device for Neural Implant Headpiece Wyss Center For Bio And Neuro Engineering CIRULNICK, EMILY NICOLE 3792 §103 Final Rejection — Pending Sep 26, 2024
18898619 System And Method For Joint Dynamic Forwarding And Caching In Content Distribution Networks California Institute Of Technology DOAN, HIEN VAN 2449 §103 Final Rejection — Pending Sep 26, 2024
18844869 Vehicular Edge Intelligence in Unlicensed Spectrum Bands Politecnico Di Torino AFRIN, NAZIA 3666 §103 Non-Final OA — Pending Sep 06, 2024
18842756 Fast Well Plate Differential Scanning Micro-Calorimeter Using Photonic Sensors The Charles Stark Draper Laboratory, Inc. LIN, ERICA S Y 2853 §102§103 Non-Final OA — Pending Aug 29, 2024
18841813 Expeditionary Shelter Systems Northeastern University HIJAZ, OMAR F 3635 §103 Non-Final OA — Pending Aug 27, 2024
18837581 Method and Apparatus for Mineral Extraction The University of Manchester MENON, KRISHNAN S 1771 §102§103§112 Non-Final OA — Pending Aug 09, 2024
18833046 METHOD FOR IMPROVING DIGESTION PERFORMANCE FOR PROTEIN IN FOOD, AND PROTEIN COMPOSITION AND FOOD CONTAINING SAME Inner Mongolia Dairy Tech Res Institute Co. Ltd. RODGERS, ARIEL M 1792 §103 Non-Final OA — Pending Jul 25, 2024
18782621 CDK9 Inhibitors and Polymorphs Thereof For Use As Agents For Treatment of Cancer Sumitomo Pharma Co., Ltd. ROZOF, TIMOTHY R 1625 §102DP Non-Final OA — Pending Jul 24, 2024
18778572 Distributed System with Fault Tolerance and Self-Maintenance Hyannis Port Research, Inc. BEYEN, ZEWDU A 2461 §103 Non-Final OA — Pending Jul 19, 2024
18773960 Droplet Assembly Method Oxford University Innovation Limited KASS, BENJAMIN JOSEPH 1798 §103§112 Non-Final OA — Pending Jul 16, 2024
18772083 Two stage plating for reduced Ni and NiO layer formation Menlo Microsystems, Inc. DUMBRIS, SETH M 1787 §102§103 Final Rejection — Pending Jul 12, 2024
18771839 Combination Therapies with Anti-CD38 Antibodies Janssen Biotech, Inc. ALSOMAIRY, SARAH ABDOALATIF 1646 §103DP Non-Final OA — Pending Jul 12, 2024
18770438 Smart Eyewear Vision Correction and Adjustment Method and System Plenoptika, Inc. STANFORD, CHRISTOPHER J 2872 §102§103§112 Final Rejection — Pending Jul 11, 2024
18758924 Compositions And Methods Targeting G12 Signaling For Bronchodilator Therapy Rutgers, The State University Of New Jersey COUGHLIN, MATTHEW P 1626 §103Other Final Rejection 13d Pending Jun 28, 2024
18759313 ENGINEERED ACID ALPHA-GLUCOSIDASE VARIANTS Crosswalk Therapeutics, Inc. CHOWDHURY, IQBAL HOSSAIN 1656 §102§112 Non-Final OA — Pending Jun 28, 2024
18724306 ZERO DWELL TIME PROCESS MONITORING Virsec Systems, Inc. SHAUGHNESSY, AIDAN EDWARD 2432 §102 Non-Final OA — Pending Jun 26, 2024
18753908 Method And Apparatus For Wireless Communications Northeastern University ARMSTRONG, JONATHAN D 3645 §102§103 Final Rejection 36d overdue Pending Jun 25, 2024
18747113 System and Method for Optimizing Sustainability for a Real-World System Cdm Smith Inc. HENRY, MATTHEW D 3625 §101§103 Final Rejection 17d overdue Pending Jun 18, 2024
18720067 Zero Trust File Integrity Protection Virsec Systems, Inc. KANAAN, SIMON P 2407 §102 Final Rejection — Pending Jun 14, 2024
18719359 Memory Hybrid-Dynamic Vulnerability Assessment Virsec Systems, Inc. MUNGUIA, DUILIO 2497 §103 Final Rejection 100d overdue Pending Jun 13, 2024
18738572 SYSTEMS AND METHODS FOR STORING A DATAFILE Dassault Systèmes Americas Corp. VUONG, CAO DANG 2153 §102§103 Non-Final OA — Pending Jun 10, 2024

View all 177 →

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Frequently Asked Questions

What is Hamilton, Brook, Smith & Reynolds, P.C.'s patent allowance rate?

77.5% of resolved applications prosecuted by Hamilton, Brook, Smith & Reynolds, P.C. were allowed, across 12,534 applications in USPTO records.

How many office actions does Hamilton, Brook, Smith & Reynolds, P.C. average before allowance?

3.85 office actions per allowed application on average.

How many pending office actions does Hamilton, Brook, Smith & Reynolds, P.C. have?

177 pending office actions as of October 2026, for 104 clients, before 171 examiners in 130 art units.

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