Prosecution Insights
Last updated: October 02, 2026

Children's Medical Center Corporation

Technology area: Biotechnology & Pharmaceuticals

29 pending office actions • 23 art units • 29 examiners • 0 of 29 (0%) have an AI response strategy ready • 20 patents granted in the last 365 days

Analysis

Children’S Medical Center Corporation has 1 pending office action in the Medical Devices & Mechanical Engineering technology area. This action is assigned to 1 distinct examiner and 1 distinct art unit. ROBINSON, NICHOLAS A is the busiest examiner, managing the pending office action.

The prosecution is highly focused, with a distinct art unit and 1 distinct examiner involved in the company's current filings. Since ROBINSON, NICHOLAS A is the examiner for the 1 pending office action, the company's progress in the Medical Devices & Mechanical Engineering area depends on this individual's review. This concentration allows for a dedicated prosecution strategy but also means that the company's outcomes are tied to the specific tendencies of the examiner.

Practitioners should note that the pending office action represents the entirety of the company's active workload in this profile. The involvement of only a distinct art unit indicates that the subject matter is localized within a specific technical group. Successfully navigating the 1 pending office action will require a thorough understanding of the requirements set forth by ROBINSON, NICHOLAS A and the standards of the art unit involved.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

29
Total Pending OAs
18
Non-Final OAs
10
Final Rejections
1
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 13 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

8
Overdue
0
Due this week
2
Due this month
2
Due in next 60 days
1
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 13 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (8)Due ≤ 30 days (2)Due ≤ 60 days (2)Due later (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

12
Hard (41%)
16
Medium (55%)
1
Easy (3%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other2 (7%)
§103 only12 (41%)
§102 only1 (3%)
§112 only1 (3%)
Double-patenting + other3 (10%)
Multi-statute (no §101)10 (34%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

20
Life Sciences
69% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
5
Mechanical / Eng
17% of docket
4
Business / Other
14% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

290 h
Manual time on pending OAs
58 h
Time saved (low, 20%)
102 h
Time saved (mid, 35%)
2.5 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
BROWN, SETH RICHARD 1 48.9% +44.3%
ZEMAN, ROBERT A 1 54.3% +27.7%
BUI, PHUONG T 1 81.2% +23.2%
XIE, XIAOZHEN 1 56.6% +65.8%
MILLER, DALE R 1 62.4% +17.5%
EPSTEIN, TODD MATTHEW 1 60.9% +43.4%
CHEN, STACY BROWN 1 66.1% +40.6%
BENAVIDES, JENNIFER ANN 1 51.2% +47.0%
PAGUIO FRISING, MICHELLE F 1 71.1% +39.3%
GHERBI, SUZETTE JAIME J 1 85.0% +8.8%

Quick Wins (1)

Cases in front of an examiner with an allow rate of 80%+ where the difficulty is Easy or Medium. The top 1 ordered by deadline are shown.

App #TitleExaminerDue in
18030473 ENGINEERING-DESIGN-BASED WORKFLOW FOR VALVE RECONSTRUCTION GHERBI, SUZETTE JAIME J —

Hard Cases (12)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17371017 MYBPC3 POLYPEPTIDES AND USES THEREOF DHAR, MATASHA 107d overdue
17422638 COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY CREWS, JARET JAMES 53d overdue
17312248 GENOMIC REARRANGEMENTS ASSOCIATED WITH PROSTATE CANCER AND METHODS OF USING THE SAME SISSON, BRADLEY L 42d overdue
17759045 IMMUNOLOGICALLY OPTIMIZED BOTULINUM TOXIN LIGHT CHAIN VARIANTS DEVI, SARVAMANGALA 36d overdue
18268477 IMPROVED RECEPTOR-BINDING DOMAIN OF BOTULINUM NEUROTOXIN A AND USES THEREOF PAGUIO FRISING, MICHELLE F 34d
18579325 EXTRACHROMOSOMAL CIRCULAR DNA AS AN IMMUNOSTIMULANT AND BIOMARKER FOR DISEASE BUI, PHUONG T —
18577206 SYSTEMS AND METHODS FOR DELIVERY BASED ON SUPRAMOLECULAR NANOSTRUCTURES XIE, XIAOZHEN —
18396181 BIODEGRADABLE LIPIDS AND FORMULATIONS FOR INTRAMUSCULAR, IN VITRO, AND EX VIVO TRANSFECTION OF MRNA MILLER, DALE R —

Interview Candidates (9)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18278394 INTERCELLULAR ADHESION MOLECULE 1 (ICAM1) ANTIBODY DRUG CONJUGATE AND USES THEREOF BENAVIDES, JENNIFER ANN 27d
18268477 IMPROVED RECEPTOR-BINDING DOMAIN OF BOTULINUM NEUROTOXIN A AND USES THEREOF PAGUIO FRISING, MICHELLE F 34d
18282215 ENGINEERED BOTULINUM NEUROTOXIN A PROTEASE DOMAIN WITH IMPROVED EFFICACY EPSTEIN, TODD MATTHEW 82d
19003564 SOFT BRACES TO PREVENT INJURY TO A JOINT OR BODY SEGMENT BROWN, SETH RICHARD —
18799550 PROTEIN ANTIGENS THAT PROVIDE PROTECTION AGAINST PNEUMOCOCCAL COLONIZATION AND/OR DISEASE ZEMAN, ROBERT A —
18579325 EXTRACHROMOSOMAL CIRCULAR DNA AS AN IMMUNOSTIMULANT AND BIOMARKER FOR DISEASE BUI, PHUONG T —
18577206 SYSTEMS AND METHODS FOR DELIVERY BASED ON SUPRAMOLECULAR NANOSTRUCTURES XIE, XIAOZHEN —
18396181 BIODEGRADABLE LIPIDS AND FORMULATIONS FOR INTRAMUSCULAR, IN VITRO, AND EX VIVO TRANSFECTION OF MRNA MILLER, DALE R —

Top Art Units

Art UnitApps
3771 2
1633 2
1691 2
3786 1
1663 1
4100 1
1699 1
1672 1
1675 1
1651 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
19003564 SOFT BRACES TO PREVENT INJURY TO A JOINT OR BODY SEGMENT BROWN, SETH RICHARD 3786 §103 Final Rejection — Pending Dec 27, 2024
18799550 PROTEIN ANTIGENS THAT PROVIDE PROTECTION AGAINST PNEUMOCOCCAL COLONIZATION AND/OR DISEASE ZEMAN, ROBERT A — §103 Non-Final OA — Pending Aug 09, 2024
18579325 EXTRACHROMOSOMAL CIRCULAR DNA AS AN IMMUNOSTIMULANT AND BIOMARKER FOR DISEASE BUI, PHUONG T 1663 §102§103§112 Non-Final OA — Pending Jan 12, 2024
18577206 SYSTEMS AND METHODS FOR DELIVERY BASED ON SUPRAMOLECULAR NANOSTRUCTURES XIE, XIAOZHEN — §102§112 Non-Final OA — Pending Jan 05, 2024
18396181 BIODEGRADABLE LIPIDS AND FORMULATIONS FOR INTRAMUSCULAR, IN VITRO, AND EX VIVO TRANSFECTION OF MRNA MILLER, DALE R 4100 §102§103 Non-Final OA — Pending Dec 26, 2023
18282215 ENGINEERED BOTULINUM NEUROTOXIN A PROTEASE DOMAIN WITH IMPROVED EFFICACY EPSTEIN, TODD MATTHEW 1699 §102 Non-Final OA 82d Pending Sep 14, 2023
18281540 POLYSACCHARIDE ADJUVANTS FOR VIRUS VACCINES CHEN, STACY BROWN 1672 §102§103 Non-Final OA — Pending Sep 11, 2023
18278394 INTERCELLULAR ADHESION MOLECULE 1 (ICAM1) ANTIBODY DRUG CONJUGATE AND USES THEREOF BENAVIDES, JENNIFER ANN 1675 §103Other Final Rejection 27d Pending Aug 22, 2023
18268477 IMPROVED RECEPTOR-BINDING DOMAIN OF BOTULINUM NEUROTOXIN A AND USES THEREOF PAGUIO FRISING, MICHELLE F 1651 §102§103 Non-Final OA 34d Pending Jun 20, 2023
18030473 ENGINEERING-DESIGN-BASED WORKFLOW FOR VALVE RECONSTRUCTION GHERBI, SUZETTE JAIME J 3774 §103 Non-Final OA — Pending Apr 05, 2023
18030467 COMPUTATIONAL PLANNING OF SURGICAL RECONSTRUCTION DIETZ, NOE ROBERT 3791 §103 Final Rejection 28d overdue Pending Apr 05, 2023
18168131 FORCE-CONTROLLED NANOSWITCH ASSAYS FOR SINGLE-MOLECULE DETECTION IN COMPLEX BIOLOGICAL FLUIDS HORLICK, KENNETH R — §112DP Non-Final OA — Pending Feb 13, 2023
18014901 GUIDING BLOOD PRODUCT ADMINISTRATION TO MITIGATE BLEEDING RISK FRITCHMAN, REBECCA M 1758 §101§103§112 Non-Final OA — Pending Jan 06, 2023
17878406 INTRACORPOREAL SUTURE TYING JAFFRI, ZEHRA 3771 §103 Final Rejection 5d overdue Pending Aug 01, 2022
17759045 IMMUNOLOGICALLY OPTIMIZED BOTULINUM TOXIN LIGHT CHAIN VARIANTS DEVI, SARVAMANGALA 1645 §102§112 Final Rejection 36d overdue Pending Jul 19, 2022
17855719 TISSUE FASTENING SCHERBEL, TODD J 3771 §103 Non-Final OA 33d Pending Jun 30, 2022
17777659 STIMULI THAT HYPERACTIVATE RESIDENT DENDRITIC CELLS FOR CANCER IMMUNOTHERAPY CHATTIN, AMY MARIE 1643 §103 Final Rejection 91d overdue Pending May 18, 2022
17769536 METHODS FOR MULTI-FOCAL IMAGING FOR MOLECULAR PROFILING CROW, ROBERT THOMAS 1600 §103§112DP Non-Final OA — Pending Apr 15, 2022
17637305 INTERCELLULAR ADHESION MOLECULE 1 (ICAM1) ANTIBODY DRUG CONJUGATE AND USES THEREOF PETRASH, HILARY ANN 1644 §102§103§112DP Final Rejection — Pending Feb 22, 2022
17635409 LARGE SCALE PRODUCTION OF EXOSOME MIMETICS AND USES THEREOF MEJIAS, SAMANTHA LEE 1618 §103 Non-Final OA 14d Pending Feb 15, 2022
17486855 ABCB5(+) STEM CELLS FOR TREATING OCULAR DISEASE FOX, ALLISON M 1633 §101§112 Non-Final OA — Pending Sep 27, 2021
17422638 COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY CREWS, JARET JAMES 1691 §103§112 Final Rejection 53d overdue Pending Jul 13, 2021
17371017 MYBPC3 POLYPEPTIDES AND USES THEREOF DHAR, MATASHA 1632 §103§112 Final Rejection 107d overdue Pending Jul 08, 2021
17312248 GENOMIC REARRANGEMENTS ASSOCIATED WITH PROSTATE CANCER AND METHODS OF USING THE SAME SISSON, BRADLEY L 1682 §103§112 Non-Final OA 42d overdue Pending Jun 09, 2021
17275266 NANOPARTICLE FORMULATIONS AND METHODS OF THEIR USE MACH, ANDRE 1615 §103 Non-Final OA — Pending Mar 11, 2021
17053752 MESENCHYMAL STROMAL CELL EXOSOME-TREATED MONOCYTES AND USES THEREOF WESTON, ALYSSA G 1633 §102§103 Non-Final OA — Pending Nov 06, 2020
16979084 COMPOSITIONS AND METHODS FOR MUTATIONS ASSOCIATED WITH SUDDEN UNEXPECTED DEATH IN PEDIATRICS LEE, ANDREW P 1691 §103 Non-Final OA 128d overdue Pending Sep 08, 2020
16639474 PURIFIED MESENCHYMAL STEM CELL EXOSOMES AND USES THEREOF WEHBE, ANNE MARIE SABRINA 1634 §112 Non-Final OA — Pending Feb 14, 2020
16628162 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA BEANE, RANDALL L 1654 §103 Final Rejection — Pending Jan 02, 2020

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