Prosecution Insights
Last updated: May 29, 2026

Ionis Pharmaceuticals Inc.

24 pending office actions • 6 art units • 17 examiners • 0 of 24 (0%) have an AI response strategy ready • 18 patents granted in the last 365 days

Portfolio Summary

24
Total Pending OAs
12
Non-Final OAs
9
Final Rejections
3
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 24 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

22
Overdue
0
Due this week
2
Due this month
0
Due in next 60 days
0
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 24 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (22)Due ≤ 30 days (2)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

0
Hard (0%)
11
Medium (46%)
4
Easy (17%)
9
Unknown (38%)

Rejection Statute Mix

BucketCases
§103 only9 (38%)
§102 only2 (8%)
§112 only4 (17%)
No statute on record9 (38%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

24
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

240 h
Manual time on pending OAs
48 h
Time saved (low, 20%)
84 h
Time saved (mid, 35%)
2.1 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
POLIAKOVA-GEORGAN, EKATERINA 4 64.6% +17.0%
VYAS, KEYUR ANILKUMAR 3 51.5% +63.5%
SHUKLA, RAM R 2 15.4% -1.8%
PERSONS, JENNA L 2 52.8% +65.0%
BEANE, RANDALL L 1 32.5% +37.8%
KRISHNAN, GANAPATHY 1 52.2% +0.0%
CHONG, KIMBERLY 1 72.4% +12.7%
TATGE, LEXUS MARC 1
KONOPKA, CATHERINE ANNE 1 58.8% +63.7%
SHIN, DANA H 1 27.2% +27.6%

Hard Cases (3)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 3 ordered by deadline are shown.

App #TitleExaminerDue in
17481679 COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION SHUKLA, RAM R 532d overdue
18158290 COMPOSITIONS AND METHODS FOR MODULATING PKK EXPRESSION SHUKLA, RAM R 58d overdue
18001241 COMPOUNDS AND METHODS FOR REDUCING MSH3 EXPRESSION SHIN, DANA H 30d overdue

Interview Candidates (13)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18443619 COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION VYAS, KEYUR ANILKUMAR 282d overdue
18150395 ANTISENSE COMPOUNDS VYAS, KEYUR ANILKUMAR 247d overdue
17424672 COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION PERSONS, JENNA L 66d overdue
17802324 COMPOUNDS AND METHODS FOR MODULATING SCN1A EXPRESSION POLIAKOVA-GEORGAN, EKATERINA 51d overdue
18001241 COMPOUNDS AND METHODS FOR REDUCING MSH3 EXPRESSION SHIN, DANA H 30d overdue
18546462 COMPOUNDS AND METHODS FOR REDUCING NLRP3 EXPRESSION CHONG, KIMBERLY 24d overdue
18585339 GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF BEANE, RANDALL L 15d overdue
17372173 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS POLIAKOVA-GEORGAN, EKATERINA 10d overdue

Top Art Units

Art UnitApps
1637 13
1635 6
1636 2
1654 1
1693 1
1615 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18585339 GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF BEANE, RANDALL L 1654 §103 Final Rejection 15d overdue Pending Feb 23, 2024
18443619 COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION VYAS, KEYUR ANILKUMAR 1637 §103 Non-Final OA 282d overdue Pending Feb 16, 2024
18548711 PURIFICATION METHODS FOR OLIGOMERIC COMPOUNDS KRISHNAN, GANAPATHY 1693 §103 Non-Final OA 8d Pending Sep 01, 2023
18546462 COMPOUNDS AND METHODS FOR REDUCING NLRP3 EXPRESSION CHONG, KIMBERLY 1636 §112 Non-Final OA 24d overdue Pending Aug 15, 2023
18263194 COMPOUNDS AND METHODS FOR MODULATING HUNTINGTIN TATGE, LEXUS MARC 1637 §103 Non-Final OA 13d Pending Jul 27, 2023
18262438 COMPOUNDS AND METHODS FOR REDUCING DUX4 EXPRESSION KONOPKA, CATHERINE ANNE 1635 Other Non-Final OA 8d overdue Pending Jul 21, 2023
18247567 METHODS FOR REDUCING APOCIII EXPRESSION POLIAKOVA-GEORGAN, EKATERINA 1637 Other Non-Final OA 4d overdue Pending Mar 31, 2023
18158290 COMPOSITIONS AND METHODS FOR MODULATING PKK EXPRESSION SHUKLA, RAM R 1635 Other Non-Final OA 58d overdue Pending Jan 23, 2023
18150395 ANTISENSE COMPOUNDS VYAS, KEYUR ANILKUMAR 1637 Other Non-Final OA 247d overdue Pending Jan 05, 2023
18001848 COMPOUNDS AND METHODS FOR MODULATING PMP22 POLIAKOVA-GEORGAN, EKATERINA 1637 §103 Non-Final OA 3d overdue Pending Dec 14, 2022
18001241 COMPOUNDS AND METHODS FOR REDUCING MSH3 EXPRESSION SHIN, DANA H 1635 §102 Non-Final OA 30d overdue Pending Dec 08, 2022
17998141 CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF ROSSI, JULIA ANNE LORRAIN 1615 §103 Non-Final OA 67d overdue Pending Nov 07, 2022
17802324 COMPOUNDS AND METHODS FOR MODULATING SCN1A EXPRESSION POLIAKOVA-GEORGAN, EKATERINA 1637 §103 Non-Final OA 51d overdue Pending Aug 25, 2022
17721765 Compositions for Modulating C9ORF72 Expression PERSONS, JENNA L 1637 Other Final Rejection 9d overdue Pending Apr 15, 2022
17611780 ANGIOTENSIN II TYPE 1 RECEPTOR TARGETED OLIGONUCLEOTIDES AND USES THEREOF ARIETI, RUTH SOPHIA 1635 Other Final Rejection 60d overdue Pending Nov 16, 2021
17522594 COMPOUNDS AND METHODS FOR REDUCING SNCA EXPRESSION MCLEOD, AFRICA MHAIRIE 1635 §112 Non-Final OA 86d overdue Pending Nov 09, 2021
17481679 COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION SHUKLA, RAM R 1635 §102 Non-Final OA 532d overdue Pending Sep 22, 2021
17432237 COMPOUNDS AND METHODS FOR REDUCING ATXN3 EXPRESSION VANHORN, ABIGAIL LOUISE 1636 §103 Final Rejection 71d overdue Pending Aug 19, 2021
17424672 COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION PERSONS, JENNA L 1637 Other Final Rejection 66d overdue Pending Jul 21, 2021
17372173 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS POLIAKOVA-GEORGAN, EKATERINA 1637 §103 Final Rejection 10d overdue Pending Jul 09, 2021
17365307 OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE TRAN, CHRISTINA L 1637 Other Final Rejection 86d overdue Pending Jul 01, 2021
17416108 MODULATORS OF HSD17B13 EXPRESSION ANGELL, JON E 1637 §112 Final Rejection 4d overdue Pending Jun 18, 2021
17291199 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING AMYOTROPHIC LATERAL SCLEROSIS QIAN, CELINE X 1637 §112 Non-Final OA 4d overdue Pending May 04, 2021
16951449 Compounds and Methods for Modulation of Transcript Processing VYAS, KEYUR ANILKUMAR 1637 Other Final Rejection 2d overdue Pending Nov 18, 2020

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