Prosecution Insights
Last updated: August 18, 2026

Ionis Pharmaceuticals Inc.

20 pending office actions • 6 art units • 14 examiners • 0 of 20 (0%) have an AI response strategy ready • 16 patents granted in the last 365 days

Portfolio Summary

20
Total Pending OAs
9
Non-Final OAs
9
Final Rejections
2
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 12 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

10
Overdue
0
Due this week
2
Due this month
0
Due in next 60 days
0
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 12 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (10)Due ≤ 30 days (2)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

8
Hard (40%)
8
Medium (40%)
3
Easy (15%)
1
Unknown (5%)

Rejection Statute Mix

BucketCases
§101 + other1 (5%)
§103 only7 (35%)
Double-patenting only3 (15%)
Double-patenting + other1 (5%)
Multi-statute (no §101)7 (35%)
No statute on record1 (5%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

20
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

200 h
Manual time on pending OAs
40 h
Time saved (low, 20%)
70 h
Time saved (mid, 35%)
1.8 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
POLIAKOVA-GEORGAN, EKATERINA 5 64.0% +17.9%
VYAS, KEYUR ANILKUMAR 3 52.1% +64.0%
BEANE, RANDALL L 1 32.8% +36.6%
KRISHNAN, GANAPATHY 1 52.4% +0.5%
SHIN, DANA H 1 27.0% +27.4%
TATGE, LEXUS MARC 1 50.0% +100.0%
MEYERING, SHABANA SHABBEER 1 69.7% +41.8%
KONOPKA, CATHERINE ANNE 1 58.2% +64.5%
CHONG, KIMBERLY 1 72.4% +12.8%
GOLDBERG, JEANINE ANNE 1 45.9% +40.9%

Hard Cases (9)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17721765 Compositions for Modulating C9ORF72 Expression PERSONS, JENNA L 9d overdue
18262438 COMPOUNDS AND METHODS FOR REDUCING DUX4 EXPRESSION KONOPKA, CATHERINE ANNE 8d overdue
17416108 MODULATORS OF HSD17B13 EXPRESSION ANGELL, JON E 4d overdue
18001848 COMPOUNDS AND METHODS FOR MODULATING PMP22 POLIAKOVA-GEORGAN, EKATERINA 3d overdue
16951449 Compounds and Methods for Modulation of Transcript Processing VYAS, KEYUR ANILKUMAR 2d overdue
18448392 Selective Antisense Compounds and Uses Thereof SHIN, DANA H
18358591 COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION MEYERING, SHABANA SHABBEER
17908135 COMPOUNDS AND METHODS FOR MODULATING KCNQ2 CHONG, KIMBERLY

Interview Candidates (15)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18443619 COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION VYAS, KEYUR ANILKUMAR 282d overdue
18150395 ANTISENSE COMPOUNDS VYAS, KEYUR ANILKUMAR 247d overdue
18585339 GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF BEANE, RANDALL L 15d overdue
17372173 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS POLIAKOVA-GEORGAN, EKATERINA 10d overdue
18262438 COMPOUNDS AND METHODS FOR REDUCING DUX4 EXPRESSION KONOPKA, CATHERINE ANNE 8d overdue
18247567 METHODS FOR REDUCING APOCIII EXPRESSION POLIAKOVA-GEORGAN, EKATERINA 4d overdue
18001848 COMPOUNDS AND METHODS FOR MODULATING PMP22 POLIAKOVA-GEORGAN, EKATERINA 3d overdue
16951449 Compounds and Methods for Modulation of Transcript Processing VYAS, KEYUR ANILKUMAR 2d overdue

Top Art Units

Art UnitApps
1637 12
1635 4
1654 1
1693 1
1636 1
1682 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18585339 GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF BEANE, RANDALL L 1654 §103Other Final Rejection 15d overdue Pending Feb 23, 2024
18443619 COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION VYAS, KEYUR ANILKUMAR 1637 §103 Final Rejection 282d overdue Pending Feb 16, 2024
18548711 PURIFICATION METHODS FOR OLIGOMERIC COMPOUNDS KRISHNAN, GANAPATHY 1693 §103 Non-Final OA 8d Pending Sep 01, 2023
18457941 MODULATORS OF PNPLA3 EXPRESSION POLIAKOVA-GEORGAN, EKATERINA 1637 §112DPOther Non-Final OA Pending Aug 29, 2023
18448392 Selective Antisense Compounds and Uses Thereof SHIN, DANA H 1635 DP Final Rejection Pending Aug 11, 2023
18263194 COMPOUNDS AND METHODS FOR MODULATING HUNTINGTIN TATGE, LEXUS MARC 1637 §103 Non-Final OA 13d Pending Jul 27, 2023
18358591 COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION MEYERING, SHABANA SHABBEER 1635 §102§103§112 Non-Final OA Pending Jul 25, 2023
18262438 COMPOUNDS AND METHODS FOR REDUCING DUX4 EXPRESSION KONOPKA, CATHERINE ANNE 1635 §101§103§112Other Non-Final OA 8d overdue Pending Jul 21, 2023
18247567 METHODS FOR REDUCING APOCIII EXPRESSION POLIAKOVA-GEORGAN, EKATERINA 1637 §103Other Non-Final OA 4d overdue Pending Mar 31, 2023
18150395 ANTISENSE COMPOUNDS VYAS, KEYUR ANILKUMAR 1637 Other Non-Final OA 247d overdue Pending Jan 05, 2023
18001848 COMPOUNDS AND METHODS FOR MODULATING PMP22 POLIAKOVA-GEORGAN, EKATERINA 1637 §102§103 Non-Final OA 3d overdue Pending Dec 14, 2022
17908773 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PREKALLIKREIN-ASSOCIATED CONDITIONS POLIAKOVA-GEORGAN, EKATERINA 1637 DP Final Rejection Pending Sep 01, 2022
17908135 COMPOUNDS AND METHODS FOR MODULATING KCNQ2 CHONG, KIMBERLY 1636 §102§103§112 Non-Final OA Pending Aug 30, 2022
17812401 GENE THERAPY AND TARGETED DELIVERY OF CONJUGATED COMPOUNDS GOLDBERG, JEANINE ANNE 1682 §103 Final Rejection Pending Jul 13, 2022
17721765 Compositions for Modulating C9ORF72 Expression PERSONS, JENNA L 1637 §102§103Other Final Rejection 9d overdue Pending Apr 15, 2022
17508516 COMPOUNDS AND METHODS FOR REDUCING SPDEF EXPRESSION ZARA, JANE J 1637 §102§103§112 Non-Final OA Pending Oct 22, 2021
17372173 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS POLIAKOVA-GEORGAN, EKATERINA 1637 §103 Final Rejection 10d overdue Pending Jul 09, 2021
17416108 MODULATORS OF HSD17B13 EXPRESSION ANGELL, JON E 1637 §102§112 Final Rejection 4d overdue Pending Jun 18, 2021
17282335 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF SULLIVAN, STEPHANIE LAUREN 1635 DP Non-Final OA Pending Apr 01, 2021
16951449 Compounds and Methods for Modulation of Transcript Processing VYAS, KEYUR ANILKUMAR 1637 §102§103§112Other Final Rejection 2d overdue Pending Nov 18, 2020

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