Prosecution Insights
Last updated: October 02, 2026

Examiner: BRETZ, COREY LANE

Tech Center 1600 • Art Units: 1600 1633 1635 1656 1658

This examiner grants 0% of resolved cases

Analysis

Corey Lane Bretz is an examiner in Tech Center 1600 and Art Unit 1600. The examiner has 3 resolved cases and an allowance rate of 0.0 percent. The interview lift is also 0.0 percent. These figures indicate that none of the 3 resolved cases have resulted in an allowance, regardless of whether an interview was conducted.

The median days to allowance for cases in this docket is 954. Practitioners should consider the 0.0 percent allowance rate as an indicator of a challenging prosecution environment in Art Unit 1600. The 0.0 percent lift suggests that current interview strategies have not yet impacted outcomes.

The 3 resolved cases provide a limited basis for understanding the 954 day timeline. The allowance rate reflects the examiner's historical approach to applications. Applicants can use the data to plan their strategy in Tech Center 1600. This profile provides a data-grounded view of the prosecution environment for this examiner.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Performance Statistics

0.0%
Allow Rate
-60.0% vs TC avg
36
Total Applications
+0.0%
Interview Lift
954
Avg Prosecution Days
Based on 3 resolved cases, 2023–2026

Rejection Statute Breakdown

5.7%
§101 Eligibility
13.3%
§102 Novelty
29.9%
§103 Obviousness
18.6%
§112 Clarity

Currently Pending Office Actions

App #TitleStatusAssignee
18338150 COMPOSITIONS AND METHODS FOR MODIFYING RNA Final Rejection The Regents of the University of California
18901470 Methods for Rule-based Genome Design Non-Final OA President and Fellows of Harvard College
17719431 Methods for Rule-based Genome Design Non-Final OA President and Fellows of Harvard College
18283262 PRODUCTION OF CIRCULAR POLYRIBONUCLEOTIDES IN A PROKARYOTIC SYSTEM Non-Final OA FLAGSHIP PIONEERING INNOVATIONS VII, LLC
18483090 COMPOUNDS, COMPOSITIONS, AND METHODS FOR USING HLA-F Non-Final OA THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
18291018 GENERATION OF LARGE PROTEINS BY CO-DELIVERY OF MULTIPLE VECTORS Non-Final OA UNIVERSITY OF WASHINGTON
17773572 ENGINEERED CELLS FOR CONTROLLED PRODUCTION Non-Final OA William Marsh Rice University
18571924 THERAPEUTIC NUCLEIC ACIDS AND METHODS OF USE THEREOF Non-Final OA Cedars-Sinai Medical Center
18350077 METHODS AND FORMULATIONS FOR GENE THERAPY, AND FOR COMBINING GENE THERAPY WITH DITPA TREATMENT, OF ALLAN-HERNDON-DUDLEY SYNDROME Final Rejection Cedars-Sinai Medical Center
18336493 SYSTEMS AND METHODS FOR TREATING CONDITIONS AND DISEASES USING ALTERNATING ELECTRIC FIELDS AND CRISPR-CAS SYSTEM Non-Final OA Novocure GmbH
17997004 COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ANGELMAN SYNDROME Final Rejection The Trustees of the University of Pennsylvania
18193033 FLUOROARABINO NUCLEIC ACID (FANA) APTAMERS THAT BIND SARS-2 RECEPTOR BINDING DOMAIN AND BLOCK BINDING TO THE ACE2 CELLULAR RECEPTOR Non-Final OA University of Maryland, College Park
18623281 RENAL INJURY BIOMARKERS AS BIOMARKERS FOR ACUTE HEPATIC PORPHYRIA (AHP) Non-Final OA Alnylam Pharmaceuticals, Inc.
17921338 TARGETED GENOMIC INTEGRATION TO RESTORE NEUROFIBROMIN CODING SEQUENCE IN NEUROFIBROMATOSIS TYPE 1 (NF1) Final Rejection Duke University
18687385 Modulation of TJPI Expression to Treat Liver Diseases Non-Final OA AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH
18151093 RECOMBINANT ADENOVIRUS GENOME HAVING A SYNTHETIC TRANSCRIPTIONAL UNIT AND TWO STEP TRANSCRIPTIONAL REGULATION AND AMPLIFICATION Non-Final OA Salk Institute for Biological Studies
17741311 COMPOSITIONS AND METHODS FOR HIGH-EFFICIENCY RECOMBINATION OF RNA MOLECULES Non-Final OA Salk Institute for Biological Studies
18573657 NON-NATURAL 5'-UNTRANSLATED REGION AND 3'-UNTRANSLATED REGION AND USE THEREOF Non-Final OA HANMI PHARM. CO., LTD.
18687892 IVT RNA MANUFACTURING PROCESS Non-Final OA GLAXOSMITHKLINE BIOLOGICALS SA
18626784 TARGETED GENE THERAPY FOR DM-1 MYOTONIC DYSTROPHY Non-Final OA Genzyme Corporation
18296283 TARGETED GENE THERAPY FOR DM-1 MYOTONIC DYSTROPHY Final Rejection Genzyme Corporation
18703672 BAG3 METHODS AND USES FOR TREATMENT OF INFLAMMATION Non-Final OA LOYOLA UNIVERSITY OF CHICAGO
17913728 FORSKOLIN-INDUCIBLE PROMOTERS AND HYPOXIA-INDUCIBLE PROMOTERS Final Rejection ASKLEPIOS BIOPHARMACEUTICAL, INC.

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