Prosecution Insights
Last updated: August 18, 2026

Seattle Children's Hospital (dba Seattle Children's Research Institute)

20 pending office actions • 12 art units • 18 examiners • 0 of 20 (0%) have an AI response strategy ready • 13 patents granted in the last 365 days

Portfolio Summary

20
Total Pending OAs
11
Non-Final OAs
8
Final Rejections
1
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 11 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

6
Overdue
2
Due this week
1
Due this month
0
Due in next 60 days
2
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 11 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (6)Due ≤ 7 days (2)Due ≤ 30 days (1)Due later (2)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

7
Hard (35%)
8
Medium (40%)
4
Easy (20%)
1
Unknown (5%)

Rejection Statute Mix

BucketCases
§101 only1 (5%)
§103 only6 (30%)
§112 only3 (15%)
Double-patenting only1 (5%)
Double-patenting + other2 (10%)
Multi-statute (no §101)6 (30%)
No statute on record1 (5%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

18
Life Sciences
90% of docket
0
Information Tech
0% of docket
1
Communications
5% of docket
0
Semiconductors
0% of docket
1
Mechanical / Eng
5% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

200 h
Manual time on pending OAs
40 h
Time saved (low, 20%)
70 h
Time saved (mid, 35%)
1.8 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
CARTER, SANDRA DILLAHUNT 2 56.1% +29.7%
NGUYEN, QUANG 2 38.1% +53.0%
GRABER, JAMES J 1 45.9% +57.0%
REGA, KYLE THOMAS 1 61.8% +40.7%
STEPHENS, AMELIA CAROLE 1 80.0% +50.0%
DIBRINO, MARIANNE 1 43.2% +41.6%
HUDSON, AMY ROSE 1 75.0% +11.4%
HUYNH, PHUONG N 1 65.7% +53.6%
DRISCOLL, MAUREEN VARINA 1 64.2% +43.7%
BATES, KEENAN ALEXANDER 1 44.8% +76.5%

Hard Cases (7)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 7 ordered by deadline are shown.

App #TitleExaminerDue in
18043497 COMPOSITIONS AND METHODS FOR TARGETING PLASMODIUM MALE GAMETE PROTEIN TO BLOCK MALARIA PARASITE TRANSMISSION XIAO, YAN 7d
18265405 ANTI-EGFR CHIMERIC ANTIGEN RECEPTORS STEPHENS, AMELIA CAROLE 14d
18012031 METHODS AND COMPOSITIONS FOR EDITING THE B2M LOCUS IN B CELLS HUDSON, AMY ROSE 71d
18441393 ENGRAFTABLE CELL-BASED IMMUNOTHERAPY FOR LONG-TERM DELIVERY OF THERAPEUTIC PROTEINS GRABER, JAMES J
18554737 ENGINEERING PEPTIDES FOR A A VB6 INTEGRIN BINDING AND RELATED METHODS OF USE AND SYNTHESIS COFFA, SERGIO
18546199 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN HOWARD, ZACHARY C
18044752 DIAGNOSTIC METHODS FOR KAWASAKI DISEASE FRITCHMAN, REBECCA M

Interview Candidates (12)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18336276 EXPRESSION OF FOXP3 IN EDITED CD34+ CELLS NGUYEN, QUANG 157d overdue
17424140 MICROENVIRONMENT SENSORS TO REGULATE ENGINEERED GENE EXPRESSION BATES, KEENAN ALEXANDER 147d overdue
17586067 METHODS OF USE FOR CAR T CELLS DRISCOLL, MAUREEN VARINA 139d overdue
17931258 BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING HUYNH, PHUONG N 16d overdue
18265405 ANTI-EGFR CHIMERIC ANTIGEN RECEPTORS STEPHENS, AMELIA CAROLE 14d
18012031 METHODS AND COMPOSITIONS FOR EDITING THE B2M LOCUS IN B CELLS HUDSON, AMY ROSE 71d
18021450 CONSTITUTIVELY ACTIVE TCF1 TO PROMOTE MEMORY-ASSOCIATED TRAITS IN CAR T CELLS REGA, KYLE THOMAS 76d
18828243 EARLY INTERVENTION METHODS TO PREVENT OR AMELIORATE TOXICITY CARTER, SANDRA DILLAHUNT

Top Art Units

Art UnitApps
1631 4
1674 3
1636 2
1641 2
1644 2
1645 1
1658 1
2671 1
1758 1
1642 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18828243 EARLY INTERVENTION METHODS TO PREVENT OR AMELIORATE TOXICITY CARTER, SANDRA DILLAHUNT 1674 §103 Final Rejection Pending Sep 09, 2024
18441393 ENGRAFTABLE CELL-BASED IMMUNOTHERAPY FOR LONG-TERM DELIVERY OF THERAPEUTIC PROTEINS GRABER, JAMES J 1631 §102§112 Non-Final OA Pending Feb 14, 2024
18021450 CONSTITUTIVELY ACTIVE TCF1 TO PROMOTE MEMORY-ASSOCIATED TRAITS IN CAR T CELLS REGA, KYLE THOMAS 1636 §103 Non-Final OA 76d Pending Aug 15, 2023
18336276 EXPRESSION OF FOXP3 IN EDITED CD34+ CELLS NGUYEN, QUANG 1631 §103DP Non-Final OA 157d overdue Pending Jun 16, 2023
18265405 ANTI-EGFR CHIMERIC ANTIGEN RECEPTORS STEPHENS, AMELIA CAROLE 1645 §102§103§112Other Non-Final OA 14d Pending Jun 05, 2023
18189433 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS DIBRINO, MARIANNE 1641 §112Other Non-Final OA Pending Mar 24, 2023
18012031 METHODS AND COMPOSITIONS FOR EDITING THE B2M LOCUS IN B CELLS HUDSON, AMY ROSE 1636 §102§103 Final Rejection 71d Pending Dec 21, 2022
17931258 BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING HUYNH, PHUONG N 1641 DP Final Rejection 16d overdue Pending Sep 12, 2022
17586067 METHODS OF USE FOR CAR T CELLS DRISCOLL, MAUREEN VARINA 1644 §103§112DP Non-Final OA 139d overdue Pending Jan 27, 2022
17426041 CHIMERIC CYTOKINE RECEPTORS CARTER, SANDRA DILLAHUNT 1674 §112 Non-Final OA Pending Jul 27, 2021
17424140 MICROENVIRONMENT SENSORS TO REGULATE ENGINEERED GENE EXPRESSION BATES, KEENAN ALEXANDER 1631 §103 Final Rejection 147d overdue Pending Jul 19, 2021
16605740 OPTIMIZED LENTIVIRAL VECTOR FOR XLA GENE THERAPY NGUYEN, QUANG 1631 §112 Final Rejection Pending Oct 16, 2019
18554737 ENGINEERING PEPTIDES FOR A A VB6 INTEGRIN BINDING AND RELATED METHODS OF USE AND SYNTHESIS COFFA, SERGIO 1658 §102§112 Final Rejection Pending Oct 10, 2023
18463683 Processing Images to Associate with Stages of a Surgical Procedure KUDO, KEN 2671 §103 Non-Final OA Pending Sep 08, 2023
18546199 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN HOWARD, ZACHARY C 1674 §102§112 Non-Final OA Pending Aug 11, 2023
18044752 DIAGNOSTIC METHODS FOR KAWASAKI DISEASE FRITCHMAN, REBECCA M 1758 §101 Final Rejection Pending Mar 09, 2023
18043497 COMPOSITIONS AND METHODS FOR TARGETING PLASMODIUM MALE GAMETE PROTEIN TO BLOCK MALARIA PARASITE TRANSMISSION XIAO, YAN 1642 §102§112 Non-Final OA 7d Pending Feb 28, 2023
18042448 SINGLE-DOMAIN ANTIBODIES THAT BIND SARS-COV-2 BARRERA, IMMACULADA 1671 Other Non-Final OA 10d overdue Pending Feb 21, 2023
18059369 MODIFIED HEMATOPOIETIC STEM/PROGENITOR AND NON-T EFFECTOR CELLS, AND USES THEREOF BELYAVSKYI, MICHAIL A 1644 §103Other Final Rejection 7d Pending Nov 28, 2022
17705082 RESUSCITATION DOSING KIT ZIEGLER, MATTHEW D 3785 §103 Non-Final OA 154d overdue Pending Mar 25, 2022

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