Prosecution Insights
Last updated: October 02, 2026

Examiner: GRABER, JAMES J

Tech Center 1600 • Art Units: 1631 1633

This examiner grants 47% of resolved cases

Analysis

James J. Graber serves as an examiner in Tech Center 1600, Art Unit 1631. With 196 resolved cases, his profile shows an allowance rate of 46.4 percent. This rate indicates a moderate level of difficulty, where just under half of the applications are successfully patented.

The interview lift is a substantial 57.5 percent. This is a critical data point, as it suggests that interviews are incredibly effective at changing the outcome of a case. For an applicant facing the 46.4 percent baseline allowance rate, the lift from an interview represents a major strategic advantage that should be utilized in almost every instance.

The median time to allowance is 1389 days. This timeline is typical for the biological and chemical arts in Tech Center 1600. The 196 resolved cases highlight a clear pattern: while the baseline success rate is moderate, the 57.5 percent interview lift makes direct communication the most powerful tool available to practitioners in Art Unit 1631.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Performance Statistics

46.7%
Allow Rate
-13.3% vs TC avg
234
Total Applications
+57.7%
Interview Lift
1388
Avg Prosecution Days
Based on 197 resolved cases, 2023–2026

Rejection Statute Breakdown

5.1%
§101 Eligibility
16.3%
§102 Novelty
35.8%
§103 Obviousness
28.8%
§112 Clarity

Currently Pending Office Actions

App #TitleStatusAssignee
18558859 UNIVERSAL RETARGETING OF ONCOLYTIC HSV Non-Final OA Janssen Biotech, Inc.
18680912 Methods of Producing Astrocytes or Promoting Astrocyte Development and Cell Culture Compositions Related Thereto Non-Final OA Emory University
18289881 3D HUMAN DISTAL LUNG ORGANOIDS CONTAINING EPITHELIAL, IMMUNE AND MESENCHYMAL COMPONENTS Final Rejection The Board of Trustees of the Leland Stanford Junior University
18568091 METHODS FOR ENGINEERING AND USE OF CILIATED ORGANOIDS HAVING NATIVE-LIKE, APICAL-OUT POLARITY Non-Final OA Carnegie Mellon University
18248193 PRODUCTION OF MEGAKARYOCYTES AND PLATELETS IN A CO-CULTURE SYSTEM Final Rejection BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
17580219 INCREASING GENOME STABILITY AND REPROGRAMMING EFFICIENCY OF INDUCED PLURIPOTENT STEM CELLS Final Rejection THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
17911018 COMPOSITION FOR INDUCING APOPTOSIS OF CELLS HAVING GENOMIC SEQUENCE VARIATION AND METHOD FOR INDUCING APOPTOSIS OF CELLS BY USING COMPOSITION Final Rejection UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
18547332 Compositions For and Methods of Improving Gene Therapy Non-Final OA Duke University
17637760 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL PAIN AND ITCH Final Rejection DUKE UNIVERSITY
17258533 USE OF IL-12 TO ALTER EPIGENETIC EFFECTOR PROGRAMS IN CD8 T CELLS Final Rejection St. Jude Children's Research Hospital
18170671 PHARMACEUTICAL COMPOSITION COMPRISING MODIFIED NATURAL KILLER CELLS AND ANTIGEN-SPECIFIC T CELLS, MANUFACTURING METHOD THEREOF, AND METHOD OF USING THE SAME Final Rejection NATIONAL YANG MING CHIAO TUNG UNIVERSITY
18567094 COMPOSITIONS AND METHODS FOR ISLET CELL TRANSPLANTS Final Rejection City of Hope
18682797 GENETICALLY MODIFIED CELLS FOR ALLOGENEIC CELL THERAPY TO REDUCE INSTANT BLOOD MEDIATED INFLAMMATORY REACTIONS Non-Final OA Sana Biotechnology, Inc.
18704322 METHOD FOR PRODUCING ORGANISM, AND METHOD FOR PROMOTING DIFFERENTIATION OF HUMAN ADIPOSE-DERIVED STEM CELLS INTO VASCULAR ENDOTHELIAL CELLS Final Rejection KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
18517402 METHOD FOR PREPARING BROWN ADIPOCYTE Non-Final OA KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION

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