Prosecution Insights
Last updated: August 16, 2026

United States Department of Health and Human Services

48 pending office actions • 27 art units • 44 examiners • 0 of 48 (0%) have an AI response strategy ready • 56 patents granted in the last 365 days

Portfolio Summary

48
Total Pending OAs
32
Non-Final OAs
16
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 16 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

8
Overdue
0
Due this week
4
Due this month
3
Due in next 60 days
1
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 16 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (8)Due ≤ 30 days (4)Due ≤ 60 days (3)Due later (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

15
Hard (31%)
21
Medium (44%)
12
Easy (25%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other3 (6%)
§103 only13 (27%)
§102 only2 (4%)
§112 only11 (23%)
Double-patenting only1 (2%)
Double-patenting + other6 (12%)
Multi-statute (no §101)12 (25%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

41
Life Sciences
85% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
7
Business / Other
15% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

480 h
Manual time on pending OAs
96 h
Time saved (low, 20%)
168 h
Time saved (mid, 35%)
4.2 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
GRIZER, CASSANDRA SENN 3 60.0% +26.7%
GILL, RACHEL B 2 65.4% +28.0%
RAMIREZ, DELIA M 2 65.1% +56.3%
CLARKE, TRENT R 1 41.1% +25.3%
COLEMAN, BRENDA LIBBY 1 74.6% +15.6%
JOHNSON, KARA D 1 69.1% +24.6%
HILL, MYRON G 1 66.2% +20.3%
JACKSON-TONGUE, LAKIA J 1 68.8% +20.8%
MCKOY, QUINCY ANDRE 1 70.3% +39.6%
BELYAVSKYI, MICHAIL A 1 64.1% +27.7%

Hard Cases (15)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18266455 COMPOSITIONS AND METHODS FOR TREATING CANCER BENAVIDES, JENNIFER ANN 52d overdue
18283516 IMMUNOGENIC COMPOSITIONS GRIZER, CASSANDRA SENN 26d overdue
18053308 ANTISENSE THERAPEUTICS FOR BETACORONAVIRUS TREATMENT BEANE, RANDALL L 10d overdue
17632783 CANCER DETECTION AND CLASSIFICATION BUCHANAN, BAILEY CHEYENNE 8d overdue
17604227 Compositions and Methods of Manufacturing Star Polymers for Ligand Display and/or Drug Delivery KAMM, JUDITH MARIE 1d overdue
17923394 ABERRANT POST-TRANSLATIONAL MODIFICATIONS (PTMS) IN METHYL- AND PROPIONIC ACIDEMIA AND A MUTANT SIRTUIN (SIRT) TO METABOLIZE PTMS BOWLES, DAVID PAUL 13d
18271901 REPLICATION-COMPETENT ADENOVIRUS TYPE 4 SARS-COV-2 VACCINES AND THEIR USE GRIZER, CASSANDRA SENN 34d
18036112 ENHANCED ANTIGEN REACTIVITY OF IMMUNE CELLS EXPRESSING A MUTANT NON-SIGNALING CD3 ZETA CHAIN ZAHORIK, AMANDA MARY 36d

Interview Candidates (14)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18283516 IMMUNOGENIC COMPOSITIONS GRIZER, CASSANDRA SENN 26d overdue
16450852 NOVEL CRISPR ENZYMES AND SYSTEMS RAMIREZ, DELIA M 9d
18271901 REPLICATION-COMPETENT ADENOVIRUS TYPE 4 SARS-COV-2 VACCINES AND THEIR USE GRIZER, CASSANDRA SENN 34d
19289498 SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS CLARKE, TRENT R
18851859 SYNTHESIS OF DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS COLEMAN, BRENDA LIBBY
18547037 FUNCTIONAL BRAIN REGION-SPECIFIC NEURAL SPHEROIDS AND METHODS OF USE JOHNSON, KARA D
18799179 CHIMERIC VECTORS HILL, MYRON G
18664031 BRACHYURY DELETION MUTANTS, NON-YEAST VECTORS ENCODING BRACHYURY DELETION MUTANTS, AND THEIR USE JACKSON-TONGUE, LAKIA J

Top Art Units

Art UnitApps
1672 4
1654 3
1624 2
1632 2
1626 2
1644 2
1636 2
1635 2
1682 2
1699 2

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
19289498 SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS CLARKE, TRENT R 1651 §102§103§112 Final Rejection Pending Aug 04, 2025
18851859 SYNTHESIS OF DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS COLEMAN, BRENDA LIBBY 1624 §102 Non-Final OA Pending Sep 27, 2024
18547037 FUNCTIONAL BRAIN REGION-SPECIFIC NEURAL SPHEROIDS AND METHODS OF USE JOHNSON, KARA D 1632 §102§103 Non-Final OA Pending Aug 18, 2023
18799179 CHIMERIC VECTORS HILL, MYRON G DP Non-Final OA Pending Aug 09, 2024
18664031 BRACHYURY DELETION MUTANTS, NON-YEAST VECTORS ENCODING BRACHYURY DELETION MUTANTS, AND THEIR USE JACKSON-TONGUE, LAKIA J 1645 §112DP Non-Final OA Pending May 14, 2024
18694167 COMPOSITIONS FOR THE TREATMENT OF FOOD AND CHEMICAL ADDICTION AND METHODS OF MAKING AND USING SAME MCKOY, QUINCY ANDRE 1626 §112 Non-Final OA Pending Mar 21, 2024
18583139 T CELL RECEPTORS RECOGNIZING MUTATED P53 BELYAVSKYI, MICHAIL A 1644 §112Other Non-Final OA Pending Feb 21, 2024
18283516 IMMUNOGENIC COMPOSITIONS GRIZER, CASSANDRA SENN 1672 §102§103§112 Final Rejection 26d overdue Pending Sep 22, 2023
18266455 COMPOSITIONS AND METHODS FOR TREATING CANCER BENAVIDES, JENNIFER ANN 1675 §102§103§112 Final Rejection 52d overdue Pending Jun 09, 2023
18036112 ENHANCED ANTIGEN REACTIVITY OF IMMUNE CELLS EXPRESSING A MUTANT NON-SIGNALING CD3 ZETA CHAIN ZAHORIK, AMANDA MARY 1636 §101§102§103 Non-Final OA 36d Pending May 09, 2023
18056356 GENE THERAPY FOR COMBINED METHYLMALONIC ACIDEMIA/ACIDURIA AND HYPERHOMOCYSTEINEMIA/HOMOCYSTINURIA, COBALAMIN C TYPE, AND DEFICIENCY OF MMACHC SHIN, DANA H 1635 §112 Final Rejection 78d Pending Nov 17, 2022
17793089 ISOTOPES OF ALPHA KETOGLUTARATE AND RELATED COMPOUNDS AND THEIR USE IN HYPERPOLARIZED IMAGING DONOHUE, SEAN R 1618 §103 Non-Final OA 43d Pending Jul 15, 2022
17638139 COMPOSITIONS INCLUDING IGG FC MUTATIONS AND USES THEREOF CUNNINGCHEN, KATHLEEN MARY 1646 §102§103 Non-Final OA Pending Feb 24, 2022
17632783 CANCER DETECTION AND CLASSIFICATION BUCHANAN, BAILEY CHEYENNE 1682 §101§102§103 Final Rejection 8d overdue Pending Feb 03, 2022
17604227 Compositions and Methods of Manufacturing Star Polymers for Ligand Display and/or Drug Delivery KAMM, JUDITH MARIE 1611 §103§112Other Final Rejection 1d overdue Pending Oct 15, 2021
17478615 MODIFIED CELLS AND METHODS OF THERAPY WEHBE, ANNE MARIE SABRINA 1634 §103 Final Rejection 28d Pending Sep 17, 2021
17214436 IMMUNORESPONSIVE CELLS EXPRESSING DOMINANT NEGATIVE FAS AND USES THEREOF MEYERING, SHABANA SHABBEER 1635 §103 Final Rejection 56d overdue Pending Mar 26, 2021
17274564 METHODS FOR DECREASING INFLUENZA-INDUCED LETHALITY USING GASTRIN-RELEASING PEPTIDE (GRP) INHIBITORS OR GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR) ANTAGONISTS GAO, ASHLEY HARTMAN 1678 §103 Final Rejection Pending Mar 09, 2021
18718766 BACTERIOPHAGE LAMBDA-VACCINE SYSTEM GILL, RACHEL B §112 Non-Final OA Pending Jun 11, 2024
18704211 SINGLE DOMAIN ANTIBODIES TARGETING THE S2 SUBUNIT OF SARS-COV-2 SPIKE PROTEIN ZOU, NIANXIANG §112 Non-Final OA Pending Apr 24, 2024
18688126 MIXED LINEAGE KINASE INHIBITORS AND METHODS OF USE GONZALEZ, LUISALBERTO 1624 §103 Non-Final OA Pending Feb 29, 2024
18681019 HIV-1 VACCINATION AND SAMT-247 MICROBICIDE TO PREVENT HIV-1 INFECTION GILL, RACHEL B §103§112DP Non-Final OA Pending Feb 02, 2024
18410773 SABRE CATALYSTS CONTAINING FLUORINATED CARBON CHAINS FOR DELIVERY OF METAL-FREE MRI CONTRAST AGENTS MCCAIG, BRIAN A §102§112 Non-Final OA Pending Jan 11, 2024
18568738 COMPOUNDS THAT BIND NON-CANONICAL G-QUADRUPLEX STRUCTURES AND METHODS OF MAKING AND USING THE SAME FETTEROLF, BRANDON J 1626 §102 Final Rejection 16d Pending Dec 08, 2023
18562806 METHODS TO GENERATE MACULAR, CENTRAL AND PERIPHERAL RETINAL PIGMENT EPITHELIAL CELLS BERTOGLIO, VALARIE E 1632 §112DP Non-Final OA Pending Nov 20, 2023
18290396 BIODEGRADABLE TISSUE SCAFFOLD WITH SECONDARY MATRIX TO HOST WEAKLY ADHERENT CELLS PYLA, EVELYN Y 1633 §103 Non-Final OA Pending Nov 13, 2023
18557396 PREFUSION-STABILIZED LASSA VIRUS GLYCOPROTEIN COMPLEX AND ITS USE CORNELIUS, CLAIRE ADRIENNE 1672 §112 Non-Final OA Pending Oct 26, 2023
18555137 RECOMBINANT CHIMERIC BOVINE/HUMAN PARAINFLUENZA VIRUS 3 EXPRESSING SARS-COV-2 SPIKE PROTEIN AND ITS USE GRIZER, CASSANDRA SENN 1672 §103§112 Non-Final OA Pending Oct 12, 2023
18235285 PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTIONS JARRELL, NOBLE E 1699 §112DP Non-Final OA Pending Aug 17, 2023
18271901 REPLICATION-COMPETENT ADENOVIRUS TYPE 4 SARS-COV-2 VACCINES AND THEIR USE GRIZER, CASSANDRA SENN 1672 §103§112 Non-Final OA 34d Pending Jul 12, 2023
18032132 HIGH CONCENTRATION METHYLCOBALAMIN OR COMBINATION OF METHYL- AND HYDROXY-COBALAMIN FOR THE TREATMENT OF COBALAMIN C DEFICIENCY DISORDERS CRAIGO, BAHAR ALAWI 1699 §103 Final Rejection 44d overdue Pending Apr 14, 2023
18053308 ANTISENSE THERAPEUTICS FOR BETACORONAVIRUS TREATMENT BEANE, RANDALL L 1654 §102§103§112Other Non-Final OA 10d overdue Pending Nov 07, 2022
17923394 ABERRANT POST-TRANSLATIONAL MODIFICATIONS (PTMS) IN METHYL- AND PROPIONIC ACIDEMIA AND A MUTANT SIRTUIN (SIRT) TO METABOLIZE PTMS BOWLES, DAVID PAUL 1654 §101§102§103§112 Non-Final OA 13d Pending Nov 04, 2022
17568298 COMPOSITIONS AND METHODS FOR REPELLING AND KILLING TICKS AND DETACHMENT OF FEEDING TICKS BAUER, NICOLA MARIA 1621 §103DP Final Rejection Pending Jan 04, 2022
18705869 USE OF CARBOXYPEPTIDASE E/NEUROTROPHIC FACTOR-ALPHA1 TO TREAT NEURODEGENERATIVE DISEASE BARRON, SEAN C 1653 §103 Non-Final OA Pending Apr 29, 2024
18262779 Imidazo[1,2- a]pyrazine and Imidazo[1,2- a]pyridine Based Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors SEITZ, ANTHONY JOSEPH 1629 §102§103§112 Non-Final OA Pending Jul 25, 2023
18346680 CANCER TREATMENT UTILIZING PRE-EXISTING MICROBIAL IMMUNITY DUNN, LINDSAY MICHELLE 1644 §112 Non-Final OA Pending Jul 03, 2023
18627191 COMPOUNDS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE OLSON, ANDREA STEFFEL §102§103 Non-Final OA Pending Apr 04, 2024
18697168 NUCLEAR MAGNETIC RESONANCE METHODS OF DETERMINING HOMEOSTATIC PERTURBATIONS XU, XIAOYUN §103 Non-Final OA Pending Mar 29, 2024
18277921 NOVEL COMPOSITIONS OF MATTER COMPRISING STABILIZED CORONAVIRUS ANTIGENS AND THEIR USE SIFFORD, JEFFREY MARK 1671 §112 Non-Final OA Pending Aug 18, 2023
18042743 METHODS TO PRODUCE VERY LONG CHAIN FATTY ACIDS (VLCFA) DAVIS, BRIAN J 1614 §112 Non-Final OA 187d overdue Pending Feb 23, 2023
18572462 SHORT APOC-II MIMETIC PEPTIDES AND METHODS OF USE DABKOWSKI, ERINNE R 1654 §103§112DP Non-Final OA Pending Dec 20, 2023
18287630 HUMAN INSULIN C-ALPHA-PEPTIDES AND METHODS OF USE LEE, JIA-HAI 1658 §103 Non-Final OA Pending Oct 19, 2023
18036392 SINGLE-CELL PROFILING OF CHROMATIN OCCUPANCY AND RNA SEQUENCING GRAY, JESSICA 1682 §103 Final Rejection Pending May 10, 2023
17904573 METHODS AND SYSTEMS FOR PREDICTING RATES OF PROGRESSION OF AGE-RELATED MACULAR DEGENERATION WOITACH, JOSEPH T 1687 §103 Final Rejection Pending Aug 18, 2022
16450852 NOVEL CRISPR ENZYMES AND SYSTEMS RAMIREZ, DELIA M 1652 §112 Non-Final OA 9d Pending Jun 24, 2019
16450699 NOVEL CRISPR ENZYMES AND SYSTEMS RAMIREZ, DELIA M 1652 §112 Final Rejection Pending Jun 24, 2019
17277397 COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION DACE DENITO, ALEXANDRA GERALDINE 1636 §103 Final Rejection Pending Mar 18, 2021

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