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| App # | Title | Client | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|---|
| 19567925 | ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS | Amazentis SA | VALENROD, YEVGENY | 1628 | DP | Non-Final OA | — | Pending | Mar 16, 2026 |
| 19542047 | COMPOSITIONS AND METHODS FOR TREATING PULMONARY ARTERIAL HYPERTENSION | Inhibikase Therapeutics, Inc. | ROZOF, TIMOTHY R | 1625 | §102§103 | Final Rejection | — | Pending | Feb 17, 2026 |
| 19436348 | COMPOSITIONS COMPRISING AN ACTIVE INGREDIENT MIXTURE COMPRISING SILICON AND BIOTIN AND METHODS OF USE | Nutrition21, LLC | PALENIK, JEFFREY T | 1615 | §102§103DP | Final Rejection | — | Pending | Dec 30, 2025 |
| 19371866 | FORMULATIONS COMPRISING INOSITOL, SILICATES, AND OPTIONALLY AMINO ACIDS WITH IMPROVED SOLUBILITY AND METHODS OF MAKING THE SAME | Nutrition21, LLC | TCHERKASSKAYA, OLGA V | 1615 | §103§112DP | Final Rejection | — | Pending | Oct 28, 2025 |
| 19334077 | HYBRID PEPPER VARIETY 'E20S0492' | Enza Zaden Beheer B.V. | FAN, WEIHUA | 1663 | §112 | Non-Final OA | — | Pending | Sep 19, 2025 |
| 19333918 | HYBRID PEPPER VARIETY 'E20S0463' | Enza Zaden Beheer B.V. | FAN, WEIHUA | 1663 | §112 | Non-Final OA | — | Pending | Sep 19, 2025 |
| 19311619 | ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS | Amazentis SA | VALENROD, YEVGENY | 1628 | §103 | Non-Final OA | — | Pending | Aug 27, 2025 |
| 19131469 | A SPINACH PLANT RESISTANT TO DOWNY MILDEW AND A RESISTANCE GENE | Enza Zaden Beheer B.V. | DEVEAU ROSEN, JASON | 1662 | §112 | Final Rejection | — | Pending | May 20, 2025 |
| 19179503 | HYBRID PEPPERS 'E20B.30395' AND 'E20B.30396' | Enza Zaden Beheer B.V. | BYRNES, DAVID R | 1662 | §101§112 | Non-Final OA | — | Pending | Apr 15, 2025 |
| 19173468 | DUAL STRUT POWER TRANSMISSION HOUSING STRUCTURE OF A MARINE PROPULSION SYSTEM | Flux Marine Ltd. | AVILA, STEPHEN P | 3615 | §103 | Non-Final OA | — | Pending | Apr 08, 2025 |
| 19170782 | ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS | Amazentis SA | VALENROD, YEVGENY | 1628 | §103 | Non-Final OA | 55d | Pending | Apr 04, 2025 |
| 19095805 | HIDDEN DESKTOP SESSION FOR REMOTE ACCESS | Connectwise, LLC | TANG, KAREN C | 2447 | §103Other | Non-Final OA | — | Pending | Mar 31, 2025 |
| 19080090 | RETRACTABLE MOLD BUILT-IN PRECISION PINS TO LOCATE COMPONENTS DURING LAYUP PROCESS FOR FABRICATION OF WIND TURBINE BLADES | Tpi Technology Inc. | DANIELS, MATTHEW J | 1742 | §103§112 | Non-Final OA | — | Pending | Mar 14, 2025 |
| 19067282 | DELIVERY OF SUSTAINED LOCAL AND SYSTEMIC IMMUNOMODULATION | The Brigham And Women'S Hospital, Inc. | CHANG, KYUNG SOOK | 1613 | §103§112 | Non-Final OA | — | Pending | Feb 28, 2025 |
| 19025640 | HEMOSTASIS VALVE AND DELIVERY SYSTEMS | Bolton Medical, Inc. | SCHERBEL, TODD J | 3771 | §102 | Non-Final OA | — | Pending | Jan 16, 2025 |
| 19008130 | SPEAKER WITH OBLIQUE MOUNTED BASS DRIVER | Lenbrook Industries Limited | GAUTHIER, GERALD | 2692 | §102 | Non-Final OA | — | Pending | Jan 02, 2025 |
| 18878271 | RESISTANCE GENE AND LETTUCE PLANT RESISTANT TO FUSARIUM WILT | Enza Zaden Beheer B.V. | PAGE, BRENT T | 1663 | §101§102§103 | Final Rejection | — | Pending | Dec 23, 2024 |
| 18877765 | COMPOSITIONS AND METHODS FOR TREATING HEARING AND OCULAR DISORDERS | Anida Pharma Inc. | JARRELL, NOBLE E | 1629 | §102§103 | Non-Final OA | — | Pending | Dec 20, 2024 |
| 18978865 | HYBRID TOMATO VARIETIES ‘E15M43062’ AND ‘E16R43164’ | Enza Zaden Beheer B.V. | BOGGS, RUSSELL T | 1663 | §112 | Non-Final OA | — | Pending | Dec 12, 2024 |
| 18977008 | VACCINES COMPRISING METHANOBREVIBACTER GOTTSCHALKII | Arkea Bio Corp. | FOLEY, SHANON A | 1671 | §103§112 | Non-Final OA | 264d overdue | Pending | Dec 11, 2024 |
| 18873070 | NOVEL TREATMENT | University Of Liverpool | HASTINGS, ALISON AZAR | 1627 | §103§112 | Non-Final OA | — | Pending | Dec 09, 2024 |
| 18869024 | LETTUCE PLANT RESISTANT TO DOWNY MILDEW AND RESISTANCE GENE | Enza Zaden Beheer B.V. | WILLIAMS, KEITH RICHARD | 1663 | §103§112 | Final Rejection | — | Pending | Nov 25, 2024 |
| 18956959 | CRYSTALLINE FORMS OF 3-SUBSTITUTED 1,2,4- OXADIAZOLE | Aurigene Discovery Technologies Limited | JACKSON, SHAWQUIA | 1626 | DP | Non-Final OA | — | Pending | Nov 22, 2024 |
| 18947339 | SYSTEM AND METHOD TO RADIALLY CONSTRICT A STENT GRAFT | Bolton Medical, Inc. | RWEGO, KANKINDI | 3771 | §102§103Other | Final Rejection | — | Pending | Nov 14, 2024 |
| 18863566 | IMMUNOBIOTICS FOR PREVENTING BACTERIAL PNEUMONIA AND METHODS OF USING THE SAME | The Regents of the University of Colorado | OGUNBIYI, OLUWATOSIN A | 1645 | §102§103§112 | Non-Final OA | — | Pending | Nov 06, 2024 |
| 18927310 | ANIMAL POSITIONING AND MONITORING SYSTEM FOR MICROSCOPY | Northeastern University | MORALES, JON ERIC C | 3786 | §102 | Non-Final OA | — | Pending | Oct 25, 2024 |
| 18913731 | DNA COLLECTION DEVICE | Sapphiros Laboratories LLC | MELHUS, BENJAMIN S | 3791 | §102§112 | Non-Final OA | — | Pending | Oct 11, 2024 |
| 18913578 | ARCHITECTURES OF LARGE LANGUAGE MODELS FOR MEDICAL TREATMENT DECISION SUPPORT | Trialmatch.Me, Inc. D/B/A/Trialjectory | ZHU, RICHARD Z | 2654 | §103 | Non-Final OA | — | Pending | Oct 11, 2024 |
| 18912145 | TEST PLUG FOR SPRINKLER ADAPTER | Ipex Usa LLC | LU, HAOTIAN | 3753 | §103 | Non-Final OA | — | Pending | Oct 10, 2024 |
| 18907230 | FEATURE PYRAMIDING FOR IN SITU DATA VISUALIZATIONS (AKA DYNAMIC DISPLAY OF MOLECULAR INFORMATION DEPENDENT ON ZOOM LEVEL) | 10X Genomics, Inc. | HUYNH, VAN D | 2665 | §102§103 | Non-Final OA | — | Pending | Oct 04, 2024 |
| 18903464 | STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF | Shanghai Hansoh Biomedical Co., Ltd. | BURKETT, DANIEL JOHN | 1624 | §102§112DP | Non-Final OA | — | Pending | Oct 01, 2024 |
| 18897839 | STYLUS DERIVED METRICS TO DETECT CENTRAL AND PERIPHERAL NERVOUS SYSTEM ATTRIBUTES | Linus Health, Inc. | OGLES, MATTHEW ERIC | 3792 | §101§102§103§112 | Non-Final OA | — | Pending | Sep 26, 2024 |
| 18894797 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. | SAEED, KAMAL A | 1626 | DP | Non-Final OA | — | Pending | Sep 24, 2024 |
| 18891617 | CRYSTALLINE SALT FORMS OF BOC-D-ARG-DMT-LYS-(BOC)-PHE-NH2 | Stealth BioTherapeutics Inc. | REYNOLDS, FRED H | 1658 | §112DP | Non-Final OA | — | Pending | Sep 20, 2024 |
| 18886316 | GENOTYPE-AGNOSTIC RESCUE OF CYSTIC FIBROSIS WITH SMALL MOLECULE BICARBONATE CHANNELS | UNIVERSITY OF IOWA RESEARCH FOUNDATION | RONEY, CELESTE A | 1612 | §103DP | Non-Final OA | — | Pending | Sep 16, 2024 |
| 18886318 | GENOTYPE-AGNOSTIC RESCUE OF CYSTIC FIBROSIS WITH SMALL MOLECULE BICARBONATE CHANNELS | UNIVERSITY OF IOWA RESEARCH FOUNDATION | RONEY, CELESTE A | 1612 | §103§112DP | Non-Final OA | — | Pending | Sep 16, 2024 |
| 18885581 | Inter-Frequency Signal Aiding For Tracking Satellite Navigation Signals | The Regents of the University of Colorado | GREGORY, BERNARR E | 3648 | §101§103§112 | Non-Final OA | — | Pending | Sep 14, 2024 |
| 18828513 | PERIODIC EXTENSIONAL FLOW REACTOR | United States Army Research Laboratory | MORENO HERNANDEZ, JERZI H | 1743 | §102§103§112 | Non-Final OA | — | Pending | Sep 09, 2024 |
| 18845283 | METHODS OF TREATING CANCER AND OTHER CONDITIONS WITH A MU OPIOID RECEPTOR ANTAGONIST | Glycyx Mor Inc. | LEE, CHIHYI NMN | 1628 | §102§103§112DP | Non-Final OA | — | Pending | Sep 09, 2024 |
| 18827231 | METHODS OF TREATING COGNITIVE IMPAIRMENT | Neurotherapia, Inc. | SANCHEZ, JUSTIN CHRISTOPHER | 1622 | §103§112 | Non-Final OA | — | Pending | Sep 06, 2024 |
| 18825626 | ULTRA-LOW POWER TEMPERATURE SENSOR DESIGN | Northeastern University | LIN, ERICA S Y | 2849 | §102§103 | Non-Final OA | — | Pending | Sep 05, 2024 |
| 18843876 | INTRAORAL MONITOR AND METHODS OF MANUFACTURE | UCHU Biosensors, Inc. | WRIGHT, ALEXANDER SCOTT | 1745 | §102§103§112 | Non-Final OA | — | Pending | Sep 04, 2024 |
| 18842526 | SPINACH PLANT RESISTANT TO DOWNY MILDEW AND NOVEL RESISTANCE GENE | Enza Zaden Beheer B.V. | ORDAZ, CHRISTIAN JOSE | 1663 | §112 | Final Rejection | 26d | Pending | Aug 29, 2024 |
| 18819461 | COMPUTATIONAL SIMULATION PLATFORM FOR PLANNING OF INTERVENTIONAL PROCEDURES | The Board Of Regents Of The University Of Nebraska | TORRES, JOSE | 2664 | §103§112 | Non-Final OA | — | Pending | Aug 29, 2024 |
| 18841884 | COMPOSITIONS COMPRISING AN ACTIVE INGREDIENT MIXTURE COMPRISING SILICON AND BIOTIN AND METHODS OF USE | Nutrition21, LLC | PALENIK, JEFFREY T | 1615 | §102 | Non-Final OA | — | Pending | Aug 27, 2024 |
| 18806984 | DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS | Sensorium Therapeutics, Inc. | RZECZYCKI, PHILLIP MATTHEW | 1625 | §103§112DP | Non-Final OA | — | Pending | Aug 16, 2024 |
| 18799074 | ALKYL-SUBSTITUTED DERIVATIVES OF MESEMBRINE AND MESEMBRENONE AND THERAPEUTIC USES THEREOF | Sensorium Therapeutics, Inc. | BRAUN, MADELINE E | 1624 | §103DP | Non-Final OA | — | Pending | Aug 09, 2024 |
| 18799037 | THERAPEUTIC ALKALOID COMPOUNDS | Sensorium Therapeutics, Inc. | HABTE, KAHSAY | 1624 | §112 | Non-Final OA | — | Pending | Aug 09, 2024 |
| 18799720 | METHOD FOR PRODUCING A COATED PERFORATED STEEL STRIP | Voestalpine Stahl GmbH | PENNY, TABATHA L | 1712 | §103 | Final Rejection | — | Pending | Aug 09, 2024 |
| 18790836 | EXTENSIBILITY NETWORKING LAYER OF AN INTEGRATION SYSTEM | Connectwise, LLC | NGUYEN, HAO HONG | 2447 | §103 | Final Rejection | 70d | Pending | Jul 31, 2024 |
| 18784462 | DEVICES FOR IMPLANTATION OF CELLULAR TRANSPLANTS AND METHODS OF USING THE SAME | The Regents of the University of Colorado | MULLINS, JESSICA LYNN | 3792 | §102§103§112 | Non-Final OA | — | Pending | Jul 25, 2024 |
| 18832458 | RECOMBINANT OPTIMIZED MECP2 CASSETTES AND METHODS FOR TREATING RETT SYNDROME AND RELATED DISORDERS | The University Court of the University of Edinburgh | GRABER, JAMES J | 1631 | §103§112Other | Non-Final OA | — | Pending | Jul 23, 2024 |
| 18730984 | COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE | The Regents of the University of California | PAK, YONG D | 1652 | §112 | Final Rejection | — | Pending | Jul 22, 2024 |
| 18730197 | SENSITIVE AND ACCURATE FEATURE VALUES FROM DEEP MALDI SPECTRA | BIODESIX, INC. | WANG, JING | 2881 | §101§112 | Final Rejection | — | Pending | Jul 18, 2024 |
| 18774339 | INFORMATION PROCESSING DEVICE, CONTROL METHOD OF INFORMATION PROCESSING DEVICE, AND PROGRAM | Kotaeru Holdings Inc. | JUNG, HENRY H | 3695 | §101 | Non-Final OA | — | Pending | Jul 16, 2024 |
| 18768496 | TREATMENT OF MIGRAINE | Allergan Pharmaceuticals International Limited | ROZOF, TIMOTHY R | 1625 | §103DP | Non-Final OA | — | Pending | Jul 10, 2024 |
| 18725593 | BICYCLIC INHIBITORS OF NICOTINAMIDE NMETHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF | President and Fellows of Harvard College | HEITMEIER, KENDALL NICOLE | 1621 | §102§112 | Non-Final OA | — | Pending | Jun 28, 2024 |
| 18724189 | ACIDIC SALT OR CRYSTAL FORM OF NITROGEN-CONTAINING FUSED RING DERIVATIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Changzhou Hansoh Pharmaceutical Co., Ltd. | BRAUN, MADELINE E | 1624 | §103§112DP | Non-Final OA | — | Pending | Jun 25, 2024 |
| 18746393 | BIOACTIVE PEPTIDES AND METHODS OF USE THEREOF | Op-T LLC | CHESTNUT, BARRY A | 1672 | §103DP | Non-Final OA | — | Pending | Jun 18, 2024 |
| 18744204 | OBFUSCATING ANALOG CIRCUITS USING SWITCHED PHASE CIRCUITS | Northeastern University | ANDERSON, MICHAEL D | 2433 | §103 | Final Rejection | — | Pending | Jun 14, 2024 |
| 18741322 | COMPOSITIONS AND METHODS FOR TREATING CANCER | The Regents of the University of California | CHICKS, ASHLI ARIANA | Other | Non-Final OA | — | Pending | Jun 12, 2024 | |
| 18741036 | CELLULAR USER LOCALIZATION SYSTEM: SMS SIDE-CHANNEL TIMING ANALYSIS METHOD AND APPARATUS | Technical University Of Dortmund | RIVAS, RAUL | 4100 | §101§103 | Non-Final OA | — | Pending | Jun 12, 2024 |
| 18736997 | BCMA CHIMERIC ANTIGEN RECEPTORS | 2Seventy Bio, Inc. | ARON, KIMBERLY A | 1633 | §103DP | Non-Final OA | — | Pending | Jun 07, 2024 |
| 18716985 | PROTEIN STABILITY ASSAY | Medicines Discovery Catapult Limited | OLSON, ALEXANDRA NADINE | 1684 | §102§103§112 | Non-Final OA | — | Pending | Jun 06, 2024 |
| 18734482 | LOW AFFINITY FcyR DEFICIENT MICE | Regeneron Pharmaceuticals, Inc. | WILSON, MICHAEL C | 1638 | §112Other | Non-Final OA | — | Pending | Jun 05, 2024 |
| 18714670 | DIAGNOSTIC TEST | Apis Assay Technologies Ltd. | KENNEDY, SARAH JANE | 1682 | §101§102 | Non-Final OA | — | Pending | May 30, 2024 |
| 18713947 | COMPOSITIONS AND METHODS FOR INHIBITING SEIZURES | The Regents of the University of California | CURRENS, GRANT CARSON | 1651 | §101§102§103§112 | Non-Final OA | — | Pending | May 28, 2024 |
| 18712285 | INDOLINES AS PROTAC COMPOUNDS | Neophore Limited | SHI, GENBIN | 1628 | §103§112 | Non-Final OA | — | Pending | May 22, 2024 |
| 18712311 | ISOINDOLINES AS PMS2 INHIBITORS | Neophore Limited | NOLAN, JASON MICHAEL | 1623 | §112 | Non-Final OA | — | Pending | May 22, 2024 |
| 18668972 | POLYURETHANE/UREA MATERIALS | Foldax, Inc. | ZIMMER, MARC S | 1765 | Other | Non-Final OA | — | Pending | May 20, 2024 |
| 18711184 | SOLID FORMS OF MESEMBRINE AND THERAPEUTIC USES THEREOF | Sensorium Therapeutics, Inc. | KUCHARCZK, JED A | 1623 | §102 | Non-Final OA | — | Pending | May 17, 2024 |
| 18706831 | EPIGENETIC TARGETS IN CLONAL HEMATOPOIESIS | Sloan-Kettering Institute For Cancer Research | WRIGHT, ERIC BRANDON | 1632 | §103§112 | Non-Final OA | — | Pending | May 02, 2024 |
| 18650592 | BIOLOGICALLY SELECTED NUCLEIC ACID ARTIFICIAL MINI-PROTEOME LIBRARIES | DANA-FARBER CANCER INSTITUTE, INC. | OLSON, ALEXANDRA NADINE | 1684 | §103§112DP | Non-Final OA | — | Pending | Apr 30, 2024 |
| 18649438 | USE OF ACIDIC ELECTROLYTE CATIONS FOR SELECTIVE ELECTROCHEMICAL CO2 AND CO CONVERSIONS TO METHANOL | Massachusetts Institute Of Technology | WONG, EDNA | 1795 | §103§112 | Non-Final OA | — | Pending | Apr 29, 2024 |
| 18705706 | DEUTERATED FORMS OF ALKALOID COMPOUNDS AND THERAPEUTIC USES THEREOF | Sensorium Therapeutics, Inc. | AULAKH, CHARANJIT | 1621 | §102 | Final Rejection | — | Pending | Apr 29, 2024 |
| 18647310 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | Biocryst Pharmaceuticals, Inc. | CORNET, JEAN P | 1628 | §103§112DP | Non-Final OA | — | Pending | Apr 26, 2024 |
| 18647916 | PREDICTIVE RFM SEGMENTATION | Punchh Inc. | EL-HAGE HASSAN, ABDALLAH A | 3623 | §101 | Non-Final OA | 5d | Pending | Apr 26, 2024 |
| 18639592 | COMPOSITIONS AND METHODS FOR MODULATING HYDROXYLATION OF ACC2 BY PHD3 | President and Fellows of Harvard College | NATARAJAN, MEERA | 1643 | §112 | Non-Final OA | — | Pending | Apr 18, 2024 |
| 18702703 | GENOME EDITING COMPOSITIONS AND METHODS FOR TREATMENT OF USHER SYNDROME TYPE 3 | Prime Medicine, Inc. | VIJAYARAGHAVAN, JAGAMYA NMN | 1633 | §103§112 | Non-Final OA | — | Pending | Apr 18, 2024 |
| 18635442 | PERICELLULAR OXYGEN-CONTROLLING CELL CULTURE INCUBATOR | Northeastern University | HAQ, SHAFIQUL | 1678 | §103 | Non-Final OA | — | Pending | Apr 15, 2024 |
| 18634264 | MODULAR BELT TENSIONING MECHANISM AND POWERHEAD STRUCTURE OF A MARINE PROPULSION SYSTEM | Flux Marine Ltd. | MISIASZEK, AMBER ALTSCHUL | 3682 | §103 | Non-Final OA | — | Pending | Apr 12, 2024 |
| 18634105 | MODULAR, REPLACEABLE OUTBOARD FAIRINGS FOR APPLICATION SPECIFIC OPTIMIZATION | Flux Marine Ltd. | VASUDEVA, AJAY | 3615 | §103§112 | Final Rejection | — | Pending | Apr 12, 2024 |
| 18700487 | COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 ANTITRYPSIN DEFICIENCY | Intellia Therapeutics, Inc. | TATGE, LEXUS MARC | 1637 | §101§103§112DP | Non-Final OA | — | Pending | Apr 11, 2024 |
| 18627985 | ARRAYS TARGETING DIFFERENTIALLY ACCESSIBLE CHROMATIN REGIONS USING QUANTITATIVE POLYMERASE CHAIN REACTION | Episteme Prognostics, Inc. | SWITZER, JULIET CAROLINE | §112 | Non-Final OA | — | Pending | Apr 05, 2024 | |
| 18627309 | CELLULAR TRANSPLANT CARRIER DEVICES AND METHODS OF USING THE SAME | The Regents of the University of Colorado | GRAY, PHILLIP A | 3783 | §102§103§112 | Non-Final OA | — | Pending | Apr 04, 2024 |
| 18697411 | DIAGNOSING MULTIPLE SCLEROSIS (MS) | The Regents of the University of Colorado | COLE, HOUSTON DAVID | 1758 | §101§102§103§112 | Non-Final OA | — | Pending | Mar 29, 2024 |
| 18608256 | MODULAR SEMI-SUBMERSIBLE OFFSHORE PLATFORM | Aikido Technologies, Inc. | VENNE, DANIEL V | 3615 | §101§102§103§112Other | Final Rejection | — | Pending | Mar 18, 2024 |
| 18690382 | SUBSTRATES AND BIOMARKERS OF ADAMTS7 | The Broad Institute, Inc. | PAGUIO FRISING, MICHELLE F | 1651 | §112 | Non-Final OA | — | Pending | Mar 08, 2024 |
| 18687436 | METHODS FOR THE GENERATION OF HUMAN RETINAL GANGLION CELLS AND COMPOSITIONS, ASSAYS, DEVICES, AND KITS COMPRISING SAME | Albert Einstein College of Medicine | BARRON, SEAN C | 1653 | §103§112 | Non-Final OA | — | Pending | Feb 28, 2024 |
| 18687601 | COMPOSITION COMPRISING a-KETOGLUTARIC ACID (a-KG) AND 5-HYDROXYMETHYL-2-FURFURAL (5-HMF) TO IMPROVE HEMOGLOBIN-MEDIATED OXYGEN SUPPLY | Cyl GmbH | CLARK, AMY LYNN | 1628 | §102§103§112 | Non-Final OA | — | Pending | Feb 28, 2024 |
| 18687108 | TREATING LONG COVID-19 WITH UROLITHINS | Amazentis SA | CORNET, JEAN P | 1628 | §103§112 | Non-Final OA | — | Pending | Feb 27, 2024 |
| 18587901 | GRIPPERS AND PLY SEPARATION METHODS | Apparel Robotics Corporation | SOTO, HENRIX | §102§103§112 | Non-Final OA | — | Pending | Feb 26, 2024 | |
| 18684986 | AMPHIPHILIC POLYAMPHOLYTES AND RELATED MEMBRANES | Trustees Of Tufts College | LEE, RIP A | 1762 | §102§112 | Non-Final OA | — | Pending | Feb 20, 2024 |
| 18444351 | LITHIUM CELL WITH LOW THERMAL RESISTANCE TERMINATION | Kiwi Technologies Inc. | THOMAS, BRENT C | 1724 | §103§112 | Non-Final OA | — | Pending | Feb 16, 2024 |
| 18444288 | PROTEIN SOLUTION FORMULATION CONTAINING HIGH CONCENTRATION OF AN ANTI-VEGF ANTIBODY | Novartis AG | KIM, YUNSOO | 1641 | §102§103DP | Non-Final OA | — | Pending | Feb 16, 2024 |
| 18683663 | RADIOFLUORINATED AGENTS FOR PET IMAGING SELECTIVELY TARGETING FIBROBLAST ACTIVATION PROTEIN | Trustees Of Tufts College | LIPPERT, JOHN WILLIAM | 1615 | §103 | Non-Final OA | — | Pending | Feb 14, 2024 |
| 18421666 | EX-VIVO CULTURE SYSTEM AND METHODS OF USING SAME | Yeda Research And Development Co. Ltd. | ZHANG SPIERING, DONGXIU | 1616 | §103 | Non-Final OA | — | Pending | Jan 24, 2024 |
| 18420205 | AORTIC PROSTHESIS WITH TUNNEL GRAFT AND EMBOLIC FILTER | Bolton Medical, Inc. | HOUSTON, ELIZABETH | 3771 | §103§112 | Non-Final OA | — | Pending | Jan 23, 2024 |
| 18580725 | INHIBITORS TARGETING UBIQUITIN SPECIFIC PROTEASE 7 (USP7) | DANA-FARBER CANCER INSTITUTE, INC. | HAVLIN, ROBERT H | 1626 | §102§103§112Other | Non-Final OA | — | Pending | Jan 19, 2024 |
| 18413789 | BLOCKCHAIN-BASED PLATFORM FOR HEALTH RECORD EXCHANGE | Blue Cross And Blue Shield Of Massachusetts, Inc. | EDOUARD, JONATHAN CHRISTOPHER | 3683 | §101§103 | Non-Final OA | — | Pending | Jan 16, 2024 |
| 18576696 | COMPOSITIONS AND METHODS FOR DECREASING PIGMENTATION | The General Hospital Corporation | GREENE, IVAN A | 1619 | §102§103 | Non-Final OA | — | Pending | Jan 04, 2024 |
| 18574587 | SEAWATER ELECTROLYSIS ENABLES SCALABLE ATMOSPHERIC CO2 MINERALIZATION | The Regents of the University of California | PARENT, ALEXANDER RENE | 1795 | §103§112Other | Non-Final OA | — | Pending | Dec 27, 2023 |
| 18573473 | (1H-PYRROLO[2,3-B]PYRIDIN-1-YL)PYRIMIDIN-2-YL-AMINO-PHENYL-ACRYLAMIDE INHIBITORS OF EGFR FOR USE IN THE TREATMENT OF BRAIN TUMORS | Crimson Biopharm Inc. | DEKARSKE, MADELINE MCGUIRE | 1622 | §103DP | Non-Final OA | — | Pending | Dec 22, 2023 |
| 18532632 | TREATMENT OF MYELOPROLIFERATIVE DISEASES AND DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN | The Regents of the University of California | ANDERSON, REBECCA L | 1626 | §102§103§112Other | Non-Final OA | — | Pending | Dec 07, 2023 |
| 18532671 | TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN | The Regents of the University of California | WARD, PAUL V | 1622 | §112 | Non-Final OA | — | Pending | Dec 07, 2023 |
| 18529532 | AIR CONDITIONING SYSTEM WITH MULTIPLE ENERGY STORAGE SUB-SYSTEMS | Transaera, Inc. | LAWRENCE JR, FRANK M | 1776 | §102§103 | Non-Final OA | 124d overdue | Pending | Dec 05, 2023 |
| 18526900 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics Inc. | RODRIGUEZ-GARCIA, VALERIE | 1621 | §103Other | Non-Final OA | — | Pending | Dec 01, 2023 |
| 18566270 | COMPOSITIONS AND METHODS FOR TREATING CELIAC DISEASE | The Regents of the University of California | ISMAIL, REHANA | 1625 | §102§103§112 | Non-Final OA | — | Pending | Dec 01, 2023 |
| 18526510 | CAPPED SYRINGES AND METHODS OF SEALING SAME | Discgenics, Inc. | FAROOQ, MAHMOOD | 3783 | §102§103 | Non-Final OA | — | Pending | Dec 01, 2023 |
| 18565336 | COMBINATION THERAPIES COMPRISING A METTL3 INHIBITOR AND A FURTHER ANTICANCER AGENT | Storm Therapeutics Limited | HOPKINS, SAMANTHA LAKE | §112Other | Non-Final OA | — | Pending | Nov 29, 2023 | |
| 18563294 | METHOD FOR MONITORING PANCREATIC BETA-CELL DESTRUCTION IN DISEASE PREDICTION/DIAGNOSIS/PROGNOSIS OF TYPE 2 DIABETES MELLITUS | Ekaterini Chatzaki | GEDRA, OLIVIA ROSE | 3681 | §101§103 | Non-Final OA | — | Pending | Nov 21, 2023 |
| 18562719 | MPLA COMPOSITIONS AND METHODS OF USE | Revelation Biosciences, Inc. | TIEN, LUCY MINYU | 1612 | §103DP | Final Rejection | 17d overdue | Pending | Nov 20, 2023 |
| 18561805 | ROBUST, HIGH-THERMAL CONDUCTANCE, CAPILLARITY-ENABLED THIN-FILM DRY CONDENSING SURFACES | Massachusetts Institute Of Technology | NOUKETCHA, LIONEL W | 3700 | §103 | Final Rejection | — | Pending | Nov 17, 2023 |
| 18562120 | ABATEMENT OF LOW LEVEL METHANE THROUGH THE USE OF CATALYTIC, EARTH-ABUNDANT MATERIALS | Massachusetts Institute Of Technology | LACLAIR, LOGAN EDWARD | 1736 | §102§103 | Non-Final OA | — | Pending | Nov 17, 2023 |
| 18511413 | CHROMIUM CONTAINING COMPOSITIONS FOR IMPROVING HEALTH AND FITNESS | Nutrition21, LLC | CHEN, CATHERYNE | 1655 | §101§102 | Final Rejection | 19d overdue | Pending | Nov 16, 2023 |
| 18511368 | CO-DEACIDIFICATION AND DECHLORINATION OF AQUEOUS/GASEOUS STREAMS BY MINERAL DISSOLUTION | The Regents of the University of California | MENDOZA, WILSON GALLARDO | 1772 | §103§112 | Final Rejection | 40d | Pending | Nov 16, 2023 |
| 18507360 | SYSTEMS AND METHODS FOR THERMAL MANAGEMENT OF REAGENT WELL PLATES | 10X Genomics, Inc. | MOORE, DEVON TYLEN | 3763 | §103 | Non-Final OA | — | Pending | Nov 13, 2023 |
| 18507648 | SYSTEMS AND METHODS FOR HEAT EXCHANGE | 10X Genomics, Inc. | ABEL, LENORA A | 1799 | §103§112 | Non-Final OA | — | Pending | Nov 13, 2023 |
| 18503569 | AORTIC PROSTHESIS DELIVERY DEVICE AND METHOD OF USE | Bolton Medical, Inc. | BARIA, DINAH N | 3774 | §102§112 | Final Rejection | 34d | Pending | Nov 07, 2023 |
| 18289418 | MIRNA INHIBITORS FOR PREVENTING AND TREATING ANEURYSMS, HYPERTENSION, ARDS AND OTHER DISEASES ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION | The Regents of the University of California | GIBBS, TERRA C | 1635 | §103§112 | Non-Final OA | — | Pending | Nov 03, 2023 |
| 18499663 | METHODS AND DEVICES OF GENERATING CLUSTERS OF AMPLICONS | Esbiolab LLC | BUNKER, AMY M | 1684 | §102§103§112 | Non-Final OA | — | Pending | Nov 01, 2023 |
| 18288484 | LIPIDOID NANOPARTICLES FOR THE TREATMENT OF DISEASES AND DISORDERS | Trustees Of Tufts College | LIPPERT, JOHN WILLIAM | 1615 | §103 | Non-Final OA | — | Pending | Oct 26, 2023 |
| 18556563 | TISSUE-SPECIFIC NUCLEIC ACID DELIVERY BY MIXED CATIONIC LIPID PARTICLES | Sepia Therapeutics, Inc. | GULLEDGE, BRIAN M | 1637 | §103 | Non-Final OA | — | Pending | Oct 20, 2023 |
| 18287229 | LIPID NANOPARTICLES COMPOSITIONS | Intellia Therapeutics, Inc. | JOHNSON, CHRISTOPHER LINDSAY | 1691 | §102§103DP | Non-Final OA | — | Pending | Oct 17, 2023 |
| 18287227 | INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND USES THEREOF | Intellia Therapeutics, Inc. | HEASLEY, MEGHAN CHRISTINE | 1626 | §103 | Non-Final OA | — | Pending | Oct 17, 2023 |
| 18286615 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | Biocryst Pharmaceuticals, Inc. | MAHLUM, JONATHAN DAVIS | 1625 | §103 | Final Rejection | — | Pending | Oct 12, 2023 |
| 18285925 | NADK2 INHIBITION IN CANCER AND FIBROTIC DISORDERS | Sloan-Kettering Institute For Cancer Research | VAN BUREN, LAUREN K | 1638 | §102§112 | Non-Final OA | — | Pending | Oct 06, 2023 |
| 18286037 | 1,3,4-OXADIAZOLE THIOCARBONYL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Chong Kun Dang Pharmaceutical Corp. | ENGLISH, CONNOR KENNEDY | 1625 | §112 | Non-Final OA | — | Pending | Oct 06, 2023 |
| 18285621 | METHODS FOR CONTROLLING IMMUNE CELL ACTIVITY | BIOSCEPTRE (AUST) PTY LTD | SZPERKA, MICHAEL EDWARD | 1641 | §102§112 | Non-Final OA | — | Pending | Oct 04, 2023 |
| 18285570 | SILICA-BASED FORMULATIONS OF THERAPEUTIC OLIOGPEPTIDES AND PEPTIDOMIMETICS | Stealth BioTherapeutics Inc. | TIEN, LUCY MINYU | 1612 | §103DP | Final Rejection | 7d | Pending | Oct 04, 2023 |
| 18478179 | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES | Prime Medicine, Inc. | MCKNIGHT, CIARA A | 1656 | §103§112 | Final Rejection | 89d overdue | Pending | Sep 29, 2023 |
| 18473740 | ORAL CARE COMPOSITIONS COMPRISING GERANYLGERANIOL AND METHODS OF USE THEREOF | American River Nutrition, LLC | GEMBEH, SHIRLEY V | 1615 | §102§103 | Non-Final OA | — | Pending | Sep 25, 2023 |
| 18283391 | BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS | Trustees Of Tufts College | DONOHUE, SEAN R | 1618 | §103§112DP | Final Rejection | — | Pending | Sep 21, 2023 |
| 18283158 | VACCINE ADJUVANT | Celleron Therapeutics Limited | OH, TAYLOR V | 1625 | §103§112 | Final Rejection | 60d overdue | Pending | Sep 20, 2023 |
| 18282671 | CLINICAL DECISION SUPPORT SYSTEMS EMPLOYING REVERSE PHENOTYPING | Albert Einstein College of Medicine | EVANS, TRISTAN ISAAC | 3683 | §101§103 | Final Rejection | 1d overdue | Pending | Sep 18, 2023 |
| 18279988 | COMPOSITIONS AND METHODS FOR TREATMENT OF BLEPHARITIS | Voom, LLC | STOCKTON, LAURA LYNNE | 1626 | §102§103§112 | Final Rejection | — | Pending | Sep 01, 2023 |
| 18455380 | PROGRAMMABLE RNA WRITING USING CRISPR EFFECTORS AND TRANS-SPLICING TEMPLATES | Massachusetts Institute Of Technology | WARD, AARON DUREL | 1636 | §102§103 | Non-Final OA | — | Pending | Aug 24, 2023 |
| 18234690 | RNA-TRIGGERED PROTEIN CLEAVAGE AND APPLICATIONS BY THE CRISPR CAS7-11-CSX29 COMPLEX | The University of Tokyo | ZARA, JANE J | 1637 | §112 | Final Rejection | 9d overdue | Pending | Aug 16, 2023 |
| 18234342 | SYSTEMS AND METHODS FOR CELL MANUFACTURING | Cellino Biotech, Inc. | NOBLE, MARCIA STEPHENS | 1632 | §102§103§112Other | Non-Final OA | — | Pending | Aug 15, 2023 |
| 18230480 | COMPOSITIONS AND METHODS FOR TREATING BRAIN INJURY | The Regents of the University of California | WEIDNER, ADAM M | 1675 | §103Other | Final Rejection | 10d overdue | Pending | Aug 04, 2023 |
| 18274823 | METHODS OF TREATING CANCERS USING STING AGONISTS | DANA-FARBER CANCER INSTITUTE, INC. | CRAIGO, BAHAR ALAWI | 1699 | §103 | Final Rejection | 12d | Pending | Jul 28, 2023 |
| 18226621 | THERAPEUTIC USES OF UROLITHIN DERIVATIVES | Vandria SA | WARD, PAUL V | 1622 | §102 | Non-Final OA | — | Pending | Jul 26, 2023 |
| 18225961 | CONTINUOUS REACTOR AND ADDITIVE MANUFACTURING OF METALS WITH NANOSTRUCTURED INCLUSIONS | Northeastern University | ALDAZ CERVANTES, MAYELA RENATA | 1733 | §102§103§112 | Final Rejection | 5d overdue | Pending | Jul 25, 2023 |
| 18273466 | T CELL-DIRECTED ANTI-CANCER VACCINES AGAINST COMMENSAL VIRUSES FOR TREATING MUCOSAL CARCINOMAS | The General Hospital Corporation | JADHAO, SAMADHAN JAISING | 1672 | §102§103§112DP | Non-Final OA | — | Pending | Jul 20, 2023 |
| 18224492 | TREATMENT OF PAIN WITH POLYSULFATED POLYSACCHARIDES | Paradigm Biopharmaceuticals Ltd. | OLSON, ANDREA STEFFEL | 1693 | §102§103 | Non-Final OA | — | Pending | Jul 20, 2023 |
| 17926847 | ANTIVIRAL POLYMERS | The University of Manchester | PIPIC, ALMA | 1617 | §103 | Final Rejection | 25d overdue | Pending | Jul 19, 2023 |
| 18223434 | VECTORS, GENETICALLY MODIFIED CELLS, AND GENETICALLY MODIFIED NON-HUMAN ANIMALS COMPRISING THE SAME | Regeneron Pharmaceuticals, Inc. | CONNORS, ALEXANDRA F | 1634 | §103§112DP | Non-Final OA | — | Pending | Jul 18, 2023 |
| 18271913 | PHARMACEUTICAL FORMULATION | Redx Pharma PLC | CHANG, KYUNG SOOK | 1613 | §103 | Final Rejection | — | Pending | Jul 12, 2023 |
| 18272024 | LIPID NANOPARTICLES FOR TARGETED DELIVERY OF MRNA | The Brigham And Women'S Hospital, Inc. | PURDY, KYLE A | 1637 | §103§112DP | Non-Final OA | — | Pending | Jul 12, 2023 |
| 18350526 | COMPOSITIONS AND METHODS FOR REDUCING METHANE EMISSIONS IN RUMINANT POPULATIONS | Arkea Bio Corp. | JOHANSEN, PETER N. | 1644 | §112 | Final Rejection | — | Pending | Jul 11, 2023 |
| 18271503 | PRODUCTS AND METHODS FOR PROMOTING MYOGENESIS | ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE | PAULUS, ERIN VIRGINIA | 1631 | §103§112 | Final Rejection | 4d overdue | Pending | Jul 10, 2023 |
| 18271135 | FABRICATION TECHNIQUE FOR HYDROGEL FILMS CONTAINING MICROPATTERNED OPAL STRUCTURES | Trustees Of Tufts College | MOUDOU, EILEEN QI-YUN | 1738 | §103§112 | Final Rejection | — | Pending | Jul 06, 2023 |
| 18269869 | HEPATOCELLULAR CARCINOMA TREATMENTS, PROPHYLACTIC THERAPIES, AND COMPOSITIONS FOR USE THEREWITH | Repair Biotechnologies, Inc. | IANNUZO, NATALIE NMN | 1653 | §102§103 | Final Rejection | 50d overdue | Pending | Jun 27, 2023 |
| 18269168 | COMPOSITIONS AND METHODS RELATED TO BICYCLO[2.2.1] HEPTANAMINE-CONTAINING COMPOUNDS | The Brigham And Women'S Hospital, Inc. | OH, TAYLOR V | 1625 | §102§103 | Final Rejection | — | Pending | Jun 22, 2023 |
| 18268733 | PROTOPARVOVIRUS AND TETRAPARVOVIRUS COMPOSITIONS AND METHODS FOR GENE THERAPY | Synteny Therapeutics, Inc. | HILL, MYRON G | 1671 | §102§103§112DP | Non-Final OA | — | Pending | Jun 21, 2023 |
| 18268688 | DOSING REGIMENS FOR ORAL ALK2 KINASE INHIBITORS | Biocryst Pharmaceuticals, Inc. | HERNANDEZ, JACKSON J | 1627 | §103Other | Final Rejection | 56d | Pending | Jun 21, 2023 |
| 18257962 | COCRYSTAL OF A CDK INHIBITOR | Aurigene Discovery Technologies Limited | LEE, CHIHYI NMN | 1628 | §103§112DP | Non-Final OA | — | Pending | Jun 16, 2023 |
| 18210452 | METHODS FOR PREPARING DNA REFERENCE MATERIALS AND CONTROLS | Seracare Life Sciences, Inc. | JOHANNSEN, DIANA B | 1682 | §101§102§103§112DP | Non-Final OA | — | Pending | Jun 15, 2023 |
| 18256277 | COMPOSITIONS AND METHODS FOR MUCOSAL DRUG DELIVERY | The Schepens Eye Research Institute, Inc. | HELM, CARALYNNE E | 1615 | §103§112 | Final Rejection | — | Pending | Jun 07, 2023 |
| 18265561 | LIPIDOID COMPOSITIONS AND METHODS OF USE THEREOF | Trustees Of Tufts College | KAMM, JUDITH MARIE | 1637 | §103§112DP | Non-Final OA | — | Pending | Jun 06, 2023 |
| 18265376 | ENHANCING MITOCHONDRIAL-BASED FLOW AND CATABOLISM OF CHOLESTEROL | Repair Biotechnologies, Inc. | BUTTICE, AUDREY L | 1647 | §103§112DP | Non-Final OA | — | Pending | Jun 05, 2023 |
| 18265380 | COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES | Annexon, Inc. | ABBAS, SYED JARAR | 1674 | §102§103§112 | Non-Final OA | 44d overdue | Pending | Jun 05, 2023 |
| 18328200 | METHODS, SYSTEMS, AND DEVICES FOR SAMPLE INTERFACE | 10X Genomics, Inc. | LYLE, SOPHIA YUAN | 1796 | §103§112 | Final Rejection | 23d | Pending | Jun 02, 2023 |
| 18328295 | ASSEMBLY FOR FORMING A SEALED CHAMBER | 10X Genomics, Inc. | RAMIREZ, ALEX | 1798 | §103 | Final Rejection | — | Pending | Jun 02, 2023 |
| 18205096 | LIPID-LIKE NANOCOMPLEXES AND USES THEREOF | Trustees Of Tufts College | ANTHOPOLOS, PETER | 1611 | §103Other | Non-Final OA | — | Pending | Jun 02, 2023 |
| 18205305 | ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS | Amazentis SA | VALENROD, YEVGENY | 1628 | §103 | Final Rejection | — | Pending | Jun 02, 2023 |
| 18202182 | METHODS AND COMPOSITION FOR TREATING METABOLIC SYNDROME | Zbiotics Company | PRAKASH, SUBBALAKSHMI | 1793 | §103 | Non-Final OA | 28d | Pending | May 25, 2023 |
| 18200875 | METAL CATIONS AS INORGANIC STRUCTURE DIRECTING AGENTS DURING THE SYNTHESIS OF PHILLIPSITE AND TOBERMORITE | The Regents of the University of California | FIGUEROA, JOHN J | 1763 | §102 | Non-Final OA | — | Pending | May 23, 2023 |
| 18037697 | METHODS OF TREATING DISEASES AND DISORDERS | Curis, Inc. | HUTTER, GILLIAN A | 1625 | §103DP | Final Rejection | — | Pending | May 18, 2023 |
| 18316464 | 3D Electrode Design for a High Specific-capacity Al-graphite Dual-ion Battery | Massachusetts Institute Of Technology | KYLE, MADISON LEIGH | 1722 | §103§112 | Final Rejection | 22d | Pending | May 12, 2023 |
| 18035373 | BINDING PROTEINS RECOGNIZING HA-1 ANTIGEN AND USES THEREOF | Tscan Therapeutics, Inc. | LEE, YIE CHIA | 1642 | §101§102§103§112 | Non-Final OA | — | Pending | May 04, 2023 |
| 18014623 | HETEROCYCLIC IMMUNOMODULATOR | BEIJING INNOCARE PHARMA TECH CO., LTD. | KUCKLA, ANNA GRACE | 1626 | §103 | Final Rejection | — | Pending | Apr 27, 2023 |
| 18032067 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | BAYER AKTIENGESELLSCHAFT | HIRAKIS, SOPHIA P | 1623 | §103DP | Final Rejection | 30d overdue | Pending | Apr 14, 2023 |
| 18132073 | HYBRID PEPPER 'E20S.10382' | Enza Zaden Beheer B.V. | BUI, PHUONG T | 1663 | §112 | Final Rejection | 121d overdue | Pending | Apr 07, 2023 |
| 18127887 | IMAGE QUANTIFICATION SYSTEM FOR ESTIMATION OF VIRAL LOAD BASED ON DETECTION BY RAPID ANTIGEN TEST | Hai Kang Life Corporation Limited | DUNN, MCKENZIE A | 1678 | §103§112 | Final Rejection | 23d overdue | Pending | Mar 29, 2023 |
| 18191495 | SLIDE-LEVEL UNCERTAINTY QUANTIFICATION FOR DEEP LEARNING PREDICTIONS IN DIGITAL HISTOPATHOLOGY | The University of Chicago | AUGER, NOAH ANDREW | 2122 | §101§102§103§112 | Non-Final OA | — | Pending | Mar 28, 2023 |
| 18026746 | METHODS OF TREATING AN INDIVIDUAL THAT HAS FAILED AN ANTI-PD-1/ANTI-PD-L1 THERAPY | DANA-FARBER CANCER INSTITUTE, INC. | BENAVIDES, JENNIFER ANN | 1675 | §102§103§112Other | Non-Final OA | 18d overdue | Pending | Mar 16, 2023 |
| 18115223 | METHOD OF CALCULATING DIAGNOSTIC SCORE FOR PROSTATE CANCER AND USE THEREOF | Urotech. Co., Ltd. | LIN, JERRY | 1671 | §101DP | Non-Final OA | — | Pending | Feb 28, 2023 |
| 18114092 | USES OF UROLITHINS | Amazentis SA | GANGLE, BRIAN J | 1645 | §102 | Final Rejection | 36d overdue | Pending | Feb 24, 2023 |
| 18168340 | VASCULAR PROSTHESES, DELIVERY SYSTEMS, AND METHODS TO TREAT AORTIC ANEURYSMS AND DISSECTIONS | VASCUTEK LIMITED | LOPEZ, LESLIE ANN | 3774 | §102§103§112 | Final Rejection | — | Pending | Feb 13, 2023 |
| 18020473 | POLYMER ELECTROLYTE COMPOSITES | Ecolectro, Inc. | KEELING, ALEXANDER W | 1795 | §103 | Final Rejection | — | Pending | Feb 09, 2023 |
| 18019940 | COMPOSITIONS AND METHODS FOR TREATING A CORONAVIRUS INFECTION | Antirna Incorporated | MCMILLIAN, KARA RENITA | 1623 | §103 | Final Rejection | — | Pending | Feb 06, 2023 |
| 18018148 | SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. | TOWNSLEY, SARA ELIZABETH | 1629 | §103Other | Final Rejection | 29d | Pending | Jan 26, 2023 |
| 18018207 | ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. | MARTIN, KEVIN STEPHEN | 1624 | §112 | Final Rejection | 31d overdue | Pending | Jan 26, 2023 |
| 18100885 | HUMANIZED ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF | Annexon, Inc. | DAHLE, CHUN WU | 1641 | Other | Final Rejection | 15d | Pending | Jan 24, 2023 |
| 18017666 | NITROGEN-CONTAINING FUSED RING DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | TOWNSLEY, SARA ELIZABETH | 1629 | §103 | Final Rejection | 71d | Pending | Jan 23, 2023 |
| 18014580 | INTERLEUKIN 33 (IL-33) INHIBITION FOR TREATMENT OF CANCER, FIBROSIS AND INFLAMMATION | The General Hospital Corporation | HERNANDEZ, JACKSON J | 1627 | §102§103 | Non-Final OA | 91d overdue | Pending | Jan 05, 2023 |
| 18013808 | COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH | Pelage Pharmaceuticals, Inc. | FETTEROLF, BRANDON J | 1626 | §103§112Other | Non-Final OA | 14d | Pending | Dec 29, 2022 |
| 18012815 | HYDROGELS | Commonwealth Scientific And Industrial Research Organisation | STEINKE, SEAN JAMES | 1619 | §103 | Final Rejection | 31d overdue | Pending | Dec 23, 2022 |
| 18011577 | COMPOSITIONS AND METHODS FOR IDENTIFYING EPITOPES | Tscan Therapeutics, Inc. | AMICK, THOMAS RUSSE | 1638 | §103 | Non-Final OA | — | Pending | Dec 20, 2022 |
| 18011354 | PRODRUGS OF MITOCHONDRIA-TARGETING OLIGOPEPTIDES | Stealth BioTherapeutics Inc. | KATAKAM, SUDHAKAR | 1658 | §103 | Non-Final OA | 26d | Pending | Dec 19, 2022 |
| 18067214 | PROGRAMMABLE INSERTION APPROACHES VIA REVERSE TRANSCRIPTASE RECRUITMENT | Massachusetts Institute Of Technology | SHEN, WU CHENG WINSTON | 1682 | §102§103§112DP | Non-Final OA | — | Pending | Dec 16, 2022 |
| 18009485 | FLUID GEL COMPOSITIONS | The University of Birmingham | FAN, LYNN Y | 1759 | §103 | Final Rejection | 11d overdue | Pending | Dec 09, 2022 |
| 18007822 | METHODS OF TREATING A CORONAVIRUS INFECTION | The General Hospital Corporation | JOHNSON, CHRISTOPHER LINDSAY | 1691 | §103 | Non-Final OA | 3d overdue | Pending | Dec 02, 2022 |
| 17927639 | AGENTS AND METHODS FOR TREATING TAUOPATHIES | The Regents of the University of California | HERNANDEZ, JACKSON J | 1627 | §112 | Final Rejection | — | Pending | Nov 23, 2022 |
| 17927112 | NUCLEIC ACID ARTIFICIAL MINI-PROTEOME LIBRARIES | The Broad Institute, Inc. | LAFAVE, ELIZABETH ROSE | 1684 | §103§112 | Non-Final OA | — | Pending | Nov 22, 2022 |
| 17984639 | BINDING PROTEINS RECOGNIZING HPV16 E7 ANTIGEN AND USES THEREOF | Tscan Therapeutics, Inc. | DRISCOLL, MAUREEN VARINA | 1644 | §112DP | Non-Final OA | — | Pending | Nov 10, 2022 |
| 17923296 | COMPOSITIONS COMPRISING ENZYMES AND PROBIOTICS, AND METHODS FOR PREVENTING OR TREATING MACULAR DEGENERATION | Genofocus, Inc. | PAGUIO FRISING, MICHELLE F | 1651 | §103Other | Non-Final OA | 34d | Pending | Nov 04, 2022 |
| 17977399 | CONSTRAINABLE STENT GRAFT, DELIVERY SYSTEM AND METHODS OF USE | Bolton Medical, Inc. | PRONE, CHRISTOPHER D | 3774 | §112 | Final Rejection | — | Pending | Oct 31, 2022 |
| 17972772 | CROMOLYN COMPOSITIONS AND METHODS THEREOF | The General Hospital Corporation | SASAN, ARADHANA | 1615 | §103 | Non-Final OA | — | Pending | Oct 25, 2022 |
| 17920588 | AFMT ANALOGS AND THEIR USE IN METHODS OF TREATING PARKINSON'S DISEASE | President and Fellows of Harvard College | WILSON, JERICA KATLYNN | 1621 | §102 | Non-Final OA | — | Pending | Oct 21, 2022 |
| 18048238 | DISCOVERY AND ENGINEERING OF INTEGRASES FOR HIGH-EFFICIENCY GENE INTEGRATION | Massachusetts Institute Of Technology | KONOPKA, CATHERINE ANNE | 1635 | §101§102§103§112DP | Non-Final OA | — | Pending | Oct 20, 2022 |
| 17917233 | MANUFACTURING OF SYNTHETIC EXOSOMES FOR CNS AND NON-CNS DELIVERY OF THERAPEUTICS | The Regents of the University of California | RONEY, CELESTE A | 1612 | §103 | Non-Final OA | 24d overdue | Pending | Oct 05, 2022 |
| 17953221 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | The Regents of the University of Colorado | AGUIRRE, AMANDA L | 1626 | §102 | Final Rejection | — | Pending | Sep 26, 2022 |
| 17947312 | METHODS FOR OBTAINING COMPOUNDS FROM A PLANT OR FUNGUS MATERIAL, RESPECTIVE COMPOSITIONS, AND USES THEREOF | Real Isolates, LLC | CHANDRAKUMAR, NIZAL S | 1625 | §103 | Final Rejection | 1d overdue | Pending | Sep 19, 2022 |
| 17802824 | FUNCTIONAL HUMAN CORNEAL ENDOTHELIAL CELLS AND APPLICATION THEREOF | Kyoto Prefectural Public University Corporation | TINSLEY, BRENDAN THOMAS | 1634 | §112 | Final Rejection | — | Pending | Aug 26, 2022 |
| 17797610 | REAL-TIME DNN EXECUTION FRAMEWORK ON MOBILE DEVICES WITH BLOCK-BASED COLUMN-ROW PRUNING | College Of William & Mary | WERNER, MARSHALL L | 2125 | §101 | Non-Final OA | — | Pending | Aug 04, 2022 |
| 17815844 | SYSTEMS FOR MEASURING PATIENT PHYSIOLOGIC PARAMETERS | UCHU Biosensors, Inc. | DOUGHERTY, SEAN PATRICK | 3791 | §112 | Non-Final OA | — | Pending | Jul 28, 2022 |
| 17868151 | SUPPORT RING FOR VASCULAR AORTIC REPAIR AND METHODS OF USE | Bolton Medical, Inc. | WOZNICKI, JACQUELINE | 3774 | §103 | Non-Final OA | 2d overdue | Pending | Jul 19, 2022 |
| 17791770 | STIMULATION OF HAIR GROWTH | The General Hospital Corporation | JOHNSON, CHRISTOPHER LINDSAY | 1691 | §103 | Non-Final OA | — | Pending | Jul 08, 2022 |
| 17787007 | ALUMINOSILICATE GLASS | Macquarie University | FORSYTH, PAUL ALAN | 1731 | §102§103 | Non-Final OA | — | Pending | Jun 24, 2022 |
| 17789019 | TARGETING THE INTRINSIC APOPTOTIC MACHINERY IN GLIOBLASTOMA | The Regents of the University of California | VALLE, ERNESTO | 1623 | §103 | Non-Final OA | — | Pending | Jun 24, 2022 |
| 17807405 | Compositions, Methods and Systems for the Delivery of Gene Editing Material to Cells | Massachusetts Institute Of Technology | GROOMS, TIFFANY NICOLE | 1637 | §102§103 | Non-Final OA | — | Pending | Jun 17, 2022 |
| 17838891 | SYNTHETIC LIPID-LIKE MATERIALS FOR BRAIN DELIVERY | Trustees Of Tufts College | DAVIS, BRIAN J | 1614 | §102 | Non-Final OA | 24d overdue | Pending | Jun 13, 2022 |
| 17781467 | COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION | Intocell, Inc. | CHANDRAKUMAR, NIZAL S | 1625 | §103Other | Final Rejection | 54d | Pending | Jun 01, 2022 |
| 17829346 | RECIPROCATING MIXING AND INJECTOR SYSTEM | Windgap Medical, Inc. | SCHMIDT, EMILY LOUISE | 3783 | §103§112 | Final Rejection | — | Pending | May 31, 2022 |
| 17769180 | COMPOSITIONS AND METHODS FOR TREATING BLOOD DISORDERS | Annexon, Inc. | TAYLOR, LIA ELAN | 1641 | §103§112Other | Non-Final OA | — | Pending | Apr 14, 2022 |
| 17761946 | USE OF DKK-1 INHIBITORS FOR TREATING CANCER | Leap Therapeutics, Inc. | LU, CHENG | 1642 | §103DP | Final Rejection | 11d overdue | Pending | Mar 18, 2022 |
| 17642322 | SUPERCRITICAL DRYING OF CHROMATOGRAPHIC MEDIA | Merck Millipore Ltd. | LACLAIR, LOGAN EDWARD | 1736 | §103 | Final Rejection | 15d | Pending | Mar 11, 2022 |
| 17633254 | HYBRID AMIDE DERIVATIVES OF AMPHOTERICIN B | The Board Of Trustees Of The University Of Illinois | GALSTER, SAMUEL LEONARD | 1693 | §103DP | Final Rejection | 61d | Pending | Feb 07, 2022 |
| 17631169 | COMPOSITE MATERIALS | Anaphite Limited | MCKINNON, LASHAWNDA T | 1789 | §102§103 | Final Rejection | 34d | Pending | Jan 28, 2022 |
| 17572448 | CARBONATION SYSTEM FOR CURING OF CONCRETE PRODUCTS AT AMBIENT PRESSURE | Susteon Inc. | CHAU, LISA N | 1785 | §112 | Non-Final OA | 46d overdue | Pending | Jan 10, 2022 |
| 16964965 | ANTIBODY-DRUG CONJUGATES THAT TARGET DLK1 AND USES THEREOF | Y-Biologics, Inc. | PUTTLITZ, KARL J | 1646 | §103§112Other | Non-Final OA | 219d overdue | Pending | Nov 30, 2021 |
| 17603707 | THERAPEUTIC COMBINATIONS, LIQUID PHARMACEUTICAL COMPOSITIONS, KITS FOR THEIR PREPARATION, AND METHODS OF THEIR USE | Prevep, Inc. | DONOGHUE, BRITTNEY ERIN | 1675 | §112 | Non-Final OA | 85d overdue | Pending | Oct 14, 2021 |
| 17602076 | Enhancement of Melanocyte Migration Using ROCK Inhibitors | The General Hospital Corporation | MCKILLOP, JOHN CHARLES | 1637 | §103 | Final Rejection | 2d overdue | Pending | Oct 07, 2021 |
| 17598761 | MIXTURES OF SYNTHETIC COPOLYPEPTIDE HYDROGELS | The Regents of the University of California | BEANE, RANDALL L | 1654 | §103§112 | Non-Final OA | 16d overdue | Pending | Sep 27, 2021 |
| 17482579 | TREATMENT OF ALZHEIMER'S DISEASE (AD) WITH AN ALUMINUM SALT | Advantage Therapeutics, Inc. | TIEN, LUCY MINYU | 1612 | §103 | Final Rejection | 21d | Pending | Sep 23, 2021 |
| 17368346 | IL-12 COMPOSITIONS AND METHODS OF USE IN HEMATOPOIETIC RECOVERY | Karyopharm Therapeutics Inc. | GEORGE, DENNIS CHERIAN | 1644 | §112 | Non-Final OA | — | Pending | Jul 06, 2021 |
| 17311180 | HETEROCYCLYL POLYMETHINE IR CHROMOPHORES | The Regents of the University of California | CRAIG, KAILA ANGELIQUE | 1618 | §103 | Final Rejection | — | Pending | Jun 04, 2021 |
| 17284363 | COMBINATION OF AN UROLITHIN WITH AN IMMUNOTHERAPY TREATMENT | Amazentis SA | MOU, LIYUAN | 1628 | §103§112Other | Non-Final OA | — | Pending | Apr 09, 2021 |
| 17176464 | COMPUTER-IMPLEMENTED METHODS AND SYSTEMS FOR ACHIEVING REAL-TIME DNN EXECUTION ON MOBILE DEVICES WITH PATTERN-BASED WEIGHT PRUNING | College Of William & Mary | PRESSLY, KURT NICHOLAS | 2125 | §101 | Final Rejection | 3d overdue | Pending | Feb 16, 2021 |
| 17265934 | MODULATING PTPN2 TO INCREASE IMMUNE RESPONSES AND PERTURBING GENE EXPRESSION IN HEMATOPOIETIC STEM CELL LINEAGES | President and Fellows of Harvard College | CUNNINGCHEN, KATHLEEN MARY | 1646 | §101§103§112 | Non-Final OA | 12d | Pending | Feb 04, 2021 |
| 17159870 | FUNGAL SPECIES, COMPOSITIONS DERIVED THEREFROM, AND USES THEREOF | President and Fellows of Harvard College | ARMATO JR, DENNIS IGNATIUS | 1651 | §103 | Final Rejection | 74d overdue | Pending | Jan 27, 2021 |
| 17255963 | NEW MOLECULAR TWEEZERS AGAINST NEUROLOGICAL DISORDERS AND VIRAL INFECTIONS | UNIVERSITAET ULM | RODRIGUEZ, RAYNA B | 1628 | §103 | Final Rejection | 29d overdue | Pending | Dec 23, 2020 |
| 17057432 | METHODS TO IDENTIFY STRUCTURAL VARIATIONS THAT CAUSE DISEASES AND THE REGIONS TO REPAIR WITH GENE EDITING | Williwaw Biosciences LLC | PULLIAM, JOSEPH CONSTANTINE | 1687 | §101§103§112 | Non-Final OA | 30d | Pending | Nov 20, 2020 |
| 17057060 | CHIMERIC ANTIGEN RECEPTORS WITH MODIFIED LINKER DOMAINS AND USES THEREOF | BIOSCEPTRE (AUST) PTY LTD | MIDDLETON, DANAYA L | 1674 | §112 | Final Rejection | 13d | Pending | Nov 19, 2020 |
| 17089448 | Diagnostic Method | Amazentis SA | FRITCHMAN, REBECCA M | 1758 | §103§112 | Non-Final OA | 49d overdue | Pending | Nov 04, 2020 |
| 16980679 | METHODS FOR TREATING OCULAR DISEASES | Novartis AG | FONTAINHAS, AURORA M | 1675 | §103Other | Non-Final OA | — | Pending | Sep 14, 2020 |
| 16640942 | METHODS FOR MODULATING THE INTERACTION BETWEEN EWS-FLI1 AND BAF COMPLEXES | The General Hospital Corporation | DENT, ALANA HARRIS | 1643 | §103§112 | Final Rejection | 87d overdue | Pending | Feb 21, 2020 |
| 16779005 | EXPANDABLE LUMINAL STENTS AND METHODS OF USE | Bolton Medical, Inc. | WOZNICKI, JACQUELINE | 3774 | §103§112 | Final Rejection | — | Pending | Jan 31, 2020 |
| 16743801 | Real Time User Matching Using Purchasing Behavior | Punchh Inc. | JORDAN, KIMBERLY L | 2194 | §103 | Non-Final OA | — | Pending | Jan 15, 2020 |
| 16490419 | DEVICES, METHODS, AND COMPOSITIONS USEFUL IN CRYO-PRESERVATION, -STORAGE, -TRANSPORT, AND APPLICATION OF THERAPEUTIC MAMMALIAN CELLS | Discgenics, Inc. | ABEL, LENORA A | 1799 | §103 | Non-Final OA | 15d overdue | Pending | Aug 30, 2019 |
| 16423344 | Portable Drug Mixing and Delivery Device and Associated Methods | Windgap Medical, Inc. | SCHMIDT, EMILY LOUISE | 3783 | §103 | Non-Final OA | — | Pending | May 28, 2019 |
| 16381791 | COMPOSITIONS AND METHODS OF IDENTIFYING TUMOR SPECIFIC NEOANTIGENS | DANA-FARBER CANCER INSTITUTE, INC. | HALVORSON, MARK | 1646 | §103 | Final Rejection | 93d overdue | Pending | Apr 11, 2019 |
| 16333855 | SCN9A ANTISENSE OLIGONUCLEOTIDES | Olipass Corporation | SHIN, DANA H | 1635 | §112DP | Non-Final OA | — | Pending | Mar 15, 2019 |
| 16094786 | IMPROVED HLA EPITOPE PREDICTION | The General Hospital Corporation | HALVORSON, MARK | 1646 | §103§112 | Final Rejection | 4d overdue | Pending | Oct 18, 2018 |
| 16078002 | HUMAN FUNCTIONAL CORNEAL ENDOTHELIAL CELL AND APPLICATION THEREOF | Kyoto Prefectural Public University Corporation | SCHUBERG, LAURA J | 1631 | §101§103DP | Non-Final OA | — | Pending | Aug 14, 2018 |
