Prosecution Insights
Last updated: May 29, 2026

Alnylam Pharmaceuticals, Inc.

31 pending office actions • 5 art units • 15 examiners • 0 of 31 (0%) have an AI response strategy ready • 32 patents granted in the last 365 days

Portfolio Summary

31
Total Pending OAs
18
Non-Final OAs
12
Final Rejections
1
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 30 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

19
Overdue
0
Due this week
6
Due this month
3
Due in next 60 days
2
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 30 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (19)Due ≤ 30 days (6)Due ≤ 60 days (3)Due later (2)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

2
Hard (6%)
10
Medium (32%)
3
Easy (10%)
16
Unknown (52%)

Rejection Statute Mix

BucketCases
§101 only2 (6%)
§103 only9 (29%)
§102 only1 (3%)
§112 only3 (10%)
No statute on record16 (52%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

31
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

310 h
Manual time on pending OAs
62 h
Time saved (low, 20%)
108 h
Time saved (mid, 35%)
2.7 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
TRAN, CHRISTINA L 5 46.8% +51.2%
GIBBS, TERRA C 4 64.1% +10.6%
POLIAKOVA-GEORGAN, EKATERINA 4 64.6% +17.0%
HUDSON, AMY ROSE 4 75.1% +11.4%
SULLIVAN, STEPHANIE LAUREN 2 60.9% +38.7%
VYAS, KEYUR ANILKUMAR 2 51.5% +63.5%
VANHORN, ABIGAIL LOUISE 2 46.7% +22.1%
BRETZ, COREY LANE 1 0.0% +0.0%
CHONG, KIMBERLY 1 72.4% +12.7%
ANGELL, JON E 1 70.7% +21.1%

Hard Cases (3)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 3 ordered by deadline are shown.

App #TitleExaminerDue in
18247314 SNCA IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SNCA-ASSOCIATED NEURODEGENERATIVE DISEASES GIBBS, TERRA C 16d overdue
18637183 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE GIBBS, TERRA C 9d overdue
18259887 2'-MODIFIED NUCLEOSIDE BASED OLIGONUCLEOTIDE PRODRUGS BRETZ, COREY LANE 69d

Interview Candidates (25)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18301089 PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF CHONG, KIMBERLY 127d overdue
17945151 COMPOSITIONS AND METHODS FOR TREATING SUBJECTS HAVING A HETEROZYGOUS ALANINE-GLYOXYLATE AMINOTRANSFERASE GENE (AGXT) VARIANT HUDSON, AMY ROSE 110d overdue
17683423 XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 110d overdue
17773508 COMPOSITIONS AND METHODS FOR SILENCING DNAJB1-PRKACA FUSION GENE EXPRESSION VYAS, KEYUR ANILKUMAR 85d overdue
18324191 METHODS AND COMPOSITIONS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION TRAN, CHRISTINA L 52d overdue
18382562 METHODS OF TREATING TRANSTHYRETIN (TTR) MEDIATED AMYLOIDOSIS POLIAKOVA-GEORGAN, EKATERINA 51d overdue
17736251 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES VANHORN, ABIGAIL LOUISE 43d overdue
18376217 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 38d overdue

Top Art Units

Art UnitApps
1637 13
1635 9
1636 7
1691 1
1693 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18978602 SNCA-TARGETING SIRNA COMPOSITIONS FOR TREATING SNCA-ASSOCIATED DISEASE SULLIVAN, STEPHANIE LAUREN 1635 Other Non-Final OA 33d Pending Dec 12, 2024
18637183 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE GIBBS, TERRA C 1635 §101 Non-Final OA 9d overdue Pending Apr 16, 2024
18581511 BETA-CATENIN (CTNNB1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF VYAS, KEYUR ANILKUMAR 1637 Other Final Rejection 79d Pending Feb 20, 2024
18427072 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION VANHORN, ABIGAIL LOUISE 1636 Other Final Rejection 5d overdue Pending Jan 30, 2024
18382562 METHODS OF TREATING TRANSTHYRETIN (TTR) MEDIATED AMYLOIDOSIS POLIAKOVA-GEORGAN, EKATERINA 1637 Other Non-Final OA 51d overdue Pending Oct 23, 2023
18376217 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 Other Final Rejection 38d overdue Pending Oct 03, 2023
18259887 2'-MODIFIED NUCLEOSIDE BASED OLIGONUCLEOTIDE PRODRUGS BRETZ, COREY LANE 1635 §103 Non-Final OA 69d Pending Jun 29, 2023
18324191 METHODS AND COMPOSITIONS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION TRAN, CHRISTINA L 1637 Other Non-Final OA 52d overdue Pending May 26, 2023
18302855 METHODS AND COMPOSITIONS FOR TREATING PRIMARY HYPEROXALURIA POLIAKOVA-GEORGAN, EKATERINA 1637 Other Non-Final OA 14d Pending Apr 19, 2023
18301089 PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF CHONG, KIMBERLY 1636 Other Non-Final OA 127d overdue Pending Apr 14, 2023
18299220 METHODS FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES USING TRANSTHYRETIN (TTR) iRNA COMPOSITIONS GIBBS, TERRA C 1635 Non-Final OA 28d Pending Apr 12, 2023
18247314 SNCA IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SNCA-ASSOCIATED NEURODEGENERATIVE DISEASES GIBBS, TERRA C 1635 §101 Non-Final OA 16d overdue Pending Mar 30, 2023
18125167 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF POLIAKOVA-GEORGAN, EKATERINA 1637 §103 Non-Final OA 25d overdue Pending Mar 23, 2023
17773508 COMPOSITIONS AND METHODS FOR SILENCING DNAJB1-PRKACA FUSION GENE EXPRESSION VYAS, KEYUR ANILKUMAR 1637 §103 Non-Final OA 85d overdue Pending Feb 09, 2023
18077271 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION GIBBS, TERRA C 1635 Other Non-Final OA 27d Pending Dec 08, 2022
17982819 CHIRALLY-ENRICHED DOUBLE-STRANDED RNA AGENTS ANGELL, JON E 1637 Other Non-Final OA 28d Pending Nov 08, 2022
17974596 APOLIPOPROTEIN E (APOE) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF TRAN, CHRISTINA L 1637 §103 Final Rejection 4d overdue Pending Oct 27, 2022
17974598 COMPLEMENT FACTOR B (CFB) IRNA COMPOSITIONS AND METHODS OF USE THEREOF TRAN, CHRISTINA L 1637 §112 Final Rejection 34d Pending Oct 27, 2022
17995568 COMPOSITIONS AND METHODS FOR SILENCING MYOC EXPRESSION MEYERING, SHABANA SHABBEER 1635 §103 Final Rejection Pending Oct 05, 2022
17995035 MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF SULLIVAN, STEPHANIE LAUREN 1635 Other Non-Final OA 32d overdue Pending Sep 29, 2022
17907664 COMPOSITIONS AND METHODS FOR SILENCING DNAJC15 GENE EXPRESSION POLIAKOVA-GEORGAN, EKATERINA 1637 §103 Non-Final OA 15d overdue Pending Sep 28, 2022
17945151 COMPOSITIONS AND METHODS FOR TREATING SUBJECTS HAVING A HETEROZYGOUS ALANINE-GLYOXYLATE AMINOTRANSFERASE GENE (AGXT) VARIANT HUDSON, AMY ROSE 1636 §102 Non-Final OA 110d overdue Pending Sep 15, 2022
17802004 G PROTEIN-COUPLED RECEPTOR 146 (GPR146) IRNA COMPOSITIONS AND METHODS OF USE THEREOF PERSONS, JENNA L 1637 §103 Final Rejection 30d Pending Aug 24, 2022
17794637 LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 §112 Final Rejection 2d overdue Pending Jul 22, 2022
17779706 SYNTHESIS OF 3 -RNA OLIGONUCLEOTIDES CREWS, JARET JAMES 1691 §103 Non-Final OA 26d overdue Pending May 25, 2022
17736251 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES VANHORN, ABIGAIL LOUISE 1636 Other Non-Final OA 43d overdue Pending May 04, 2022
17683423 XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 Other Non-Final OA 110d overdue Pending Mar 01, 2022
17672771 NEUROFILAMENT LIGHT CHAIN (NFL) AS A BIOMARKER FOR TRANSTHYRETIN AMYLOIDOSIS POLYNEUROPATHY TRAN, CHRISTINA L 1637 §112 Final Rejection 30d overdue Pending Feb 16, 2022
17611761 ORAL DELIVERY OF OLIGONUCLEOTIDES TRAN, CHRISTINA L 1637 Other Final Rejection 49d Pending Nov 16, 2021
17314909 AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF SHIN, DANA H 1635 Final Rejection 13d Pending May 07, 2021
17250952 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS BRANDSEN, BENJAMIN MICHAEL 1693 §103 Final Rejection 230d overdue Pending Apr 01, 2021

Managing Alnylam Pharmaceuticals, Inc.'s Patent Portfolio?

IP Author helps IP teams respond to office actions faster with AI-generated responses, examiner analytics, and prosecution intelligence.

Start Free Trial

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month