Prosecution Insights
Last updated: August 16, 2026

Alnylam Pharmaceuticals Inc.

40 pending office actions • 5 art units • 23 examiners • 0 of 40 (0%) have an AI response strategy ready • 26 patents granted in the last 365 days

Portfolio Summary

40
Total Pending OAs
22
Non-Final OAs
16
Final Rejections
2
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 16 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

10
Overdue
0
Due this week
3
Due this month
2
Due in next 60 days
1
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 16 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (10)Due ≤ 30 days (3)Due ≤ 60 days (2)Due later (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

18
Hard (45%)
16
Medium (40%)
6
Easy (15%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other3 (8%)
§103 only9 (22%)
§112 only4 (10%)
Double-patenting only2 (5%)
Double-patenting + other7 (18%)
Multi-statute (no §101)15 (38%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

35
Life Sciences
88% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
5
Business / Other
12% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

400 h
Manual time on pending OAs
80 h
Time saved (low, 20%)
140 h
Time saved (mid, 35%)
3.5 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
HUDSON, AMY ROSE 5 75.0% +11.4%
POLIAKOVA-GEORGAN, EKATERINA 4 64.0% +17.9%
SULLIVAN, STEPHANIE LAUREN 3 58.6% +39.6%
GIBBS, TERRA C 3 63.9% +10.4%
TRAN, CHRISTINA L 3 48.2% +45.5%
WHITEMAN, BRIAN A 2 68.4% +16.7%
ALLEN, SARAH ELIZABETH 2 60.9% +45.0%
SHIN, DANA H 2 27.0% +27.4%
MCKILLOP, JOHN CHARLES 2 56.3% +40.7%
ZAHORIK, AMANDA MARY 1 57.5% +48.2%

Hard Cases (20)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18301089 PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF CHONG, KIMBERLY 127d overdue
17773508 COMPOSITIONS AND METHODS FOR SILENCING DNAJB1-PRKACA FUSION GENE EXPRESSION VYAS, KEYUR ANILKUMAR 85d overdue
17736251 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES VANHORN, ABIGAIL LOUISE 43d overdue
18247314 SNCA IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SNCA-ASSOCIATED NEURODEGENERATIVE DISEASES GIBBS, TERRA C 16d overdue
18302855 METHODS AND COMPOSITIONS FOR TREATING PRIMARY HYPEROXALURIA POLIAKOVA-GEORGAN, EKATERINA 14d
17802004 G PROTEIN-COUPLED RECEPTOR 146 (GPR146) IRNA COMPOSITIONS AND METHODS OF USE THEREOF PERSONS, JENNA L 30d
17611761 ORAL DELIVERY OF OLIGONUCLEOTIDES TRAN, CHRISTINA L 49d
18259887 2'-MODIFIED NUCLEOSIDE BASED OLIGONUCLEOTIDE PRODRUGS BRETZ, COREY LANE 69d

Interview Candidates (27)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17683423 XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 110d overdue
18382562 METHODS OF TREATING TRANSTHYRETIN (TTR) MEDIATED AMYLOIDOSIS POLIAKOVA-GEORGAN, EKATERINA 51d overdue
18376217 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 38d overdue
17995035 MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF SULLIVAN, STEPHANIE LAUREN 32d overdue
18247314 SNCA IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SNCA-ASSOCIATED NEURODEGENERATIVE DISEASES GIBBS, TERRA C 16d overdue
17974596 APOLIPOPROTEIN E (APOE) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF TRAN, CHRISTINA L 4d overdue
18302855 METHODS AND COMPOSITIONS FOR TREATING PRIMARY HYPEROXALURIA POLIAKOVA-GEORGAN, EKATERINA 14d
18077271 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION GIBBS, TERRA C 27d

Top Art Units

Art UnitApps
1637 14
1636 10
1635 9
1653 1
1691 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18978602 SNCA-TARGETING SIRNA COMPOSITIONS FOR TREATING SNCA-ASSOCIATED DISEASE SULLIVAN, STEPHANIE LAUREN 1635 §103Other Non-Final OA 33d Pending Dec 12, 2024
18761504 COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE ZAHORIK, AMANDA MARY §102§103§112 Non-Final OA Pending Jul 02, 2024
18613537 3'-OH RNA-CONTAINING OLIGONUCLEOTIDE DEPROTECTION CHO, DAVID H §102§103§112DP Non-Final OA Pending Mar 22, 2024
18434928 COMPOSITIONS AND METHODS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION HUDSON, AMY ROSE 1636 §103 Final Rejection Pending Feb 07, 2024
18577948 MULTIPLEXING TARGETING LIGANDS THROUGH CLICK CHEMISTRY AT THE ANOMERIC SITE OF SUGARS LEE, HOI YAN NMN §102§103§112Other Non-Final OA Pending Jan 09, 2024
18403862 METHODS AND COMPOSITIONS FOR TREATING SUBJECTS HAVING OR AT RISK OF DEVELOPING A NON-PRIMARY HYPEROXALURIA DISEASE OR DISORDER WHITEMAN, BRIAN A §102§103§112DP Non-Final OA Pending Jan 04, 2024
18542950 METHODS AND COMPOSITIONS FOR TREATING AN ANGIOTENSINOGEN- (AGT-) ASSOCIATED DISORDER GIBBS, TERRA C §103§112DP Non-Final OA Pending Dec 18, 2023
18382562 METHODS OF TREATING TRANSTHYRETIN (TTR) MEDIATED AMYLOIDOSIS POLIAKOVA-GEORGAN, EKATERINA 1637 §103Other Non-Final OA 51d overdue Pending Oct 23, 2023
18556180 REDIRECTING RISC FOR RNA EDITING ALLEN, SARAH ELIZABETH 1653 §101§102§103§112 Non-Final OA Pending Oct 19, 2023
18376217 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 DP Non-Final OA 38d overdue Pending Oct 03, 2023
18373397 PROLINE DEHYDROGENASE 2 (PRODH2) IRNA COMPOSITIONS AND METHODS OF USE THEREOF POLIAKOVA-GEORGAN, EKATERINA 1637 §103 Non-Final OA Pending Sep 27, 2023
18548634 DOSING OF siRNA COMPOUNDS TO THE CISTERNA MAGNA HUDSON, AMY ROSE 1636 §102§103§112 Non-Final OA Pending Sep 01, 2023
18236437 PRION PROTEIN (PRNP) IRNA COMPOSITIONS AND METHODS OF USE THEREOF YU, DELPHINUS DOU YI 1636 §103DP Non-Final OA Pending Aug 22, 2023
18547102 FOLLICULIN iRNA COMPOSITIONS AND METHODS THEREOF KONOPKA, CATHERINE ANNE 1636 §101§102§103§112DP Non-Final OA Pending Aug 18, 2023
18259887 2'-MODIFIED NUCLEOSIDE BASED OLIGONUCLEOTIDE PRODRUGS BRETZ, COREY LANE 1635 §102§103 Non-Final OA 69d Pending Jun 29, 2023
18136386 MUCIN 5B (MUC5B) IRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 §102§103§112 Non-Final OA Pending Apr 19, 2023
18302855 METHODS AND COMPOSITIONS FOR TREATING PRIMARY HYPEROXALURIA POLIAKOVA-GEORGAN, EKATERINA 1637 §103§112Other Final Rejection 14d Pending Apr 19, 2023
18301089 PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF CHONG, KIMBERLY 1636 §102§103Other Final Rejection 127d overdue Pending Apr 14, 2023
18131892 SUPEROXIDE DISMUTASE 1 (SOD1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SUPEROXIDE DISMUTASE 1- (SOD1-) ASSOCIATED NEURODEGENERATIVE DISEASES ANGELL, JON E 1637 §102§103 Non-Final OA Pending Apr 07, 2023
18247314 SNCA IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SNCA-ASSOCIATED NEURODEGENERATIVE DISEASES GIBBS, TERRA C 1635 §101§102§103§112 Non-Final OA 16d overdue Pending Mar 30, 2023
17773508 COMPOSITIONS AND METHODS FOR SILENCING DNAJB1-PRKACA FUSION GENE EXPRESSION VYAS, KEYUR ANILKUMAR 1637 §103§112 Final Rejection 85d overdue Pending Feb 09, 2023
18007007 ATXN2 IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING ATXN2-ASSOCIATED NEURODEGENERATIVE DISEASES WHITEMAN, BRIAN A 1636 §112 Final Rejection Pending Jan 26, 2023
18015202 Circular siRNAs TRAN, CHRISTINA L 1637 §103 Final Rejection Pending Jan 09, 2023
18001813 ANAPLASTIC LYMPHOMA KINASE (ALK) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF SULLIVAN, STEPHANIE LAUREN 1635 §102§103 Final Rejection Pending Dec 14, 2022
18077271 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION GIBBS, TERRA C 1635 §112Other Non-Final OA 27d Pending Dec 08, 2022
18001065 SIRNA COMPOSITIONS AND METHODS FOR SILENCING GPAM (GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL) EXPRESSION SHIN, DANA H 1635 §112 Final Rejection Pending Dec 07, 2022
18001050 TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6 (TRAF6) iRNA COMPOSITIONS AND METHODS OF USE THEREOF POLIAKOVA-GEORGAN, EKATERINA 1637 §102§103 Non-Final OA Pending Dec 07, 2022
17999320 COMPOSITIONS AND METHODS FOR INHIBITING MARC1 GENE EXPRESSION SHIN, DANA H 1635 §112 Non-Final OA Pending Nov 18, 2022
17974596 APOLIPOPROTEIN E (APOE) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF TRAN, CHRISTINA L 1637 §103 Final Rejection 4d overdue Pending Oct 27, 2022
17995568 COMPOSITIONS AND METHODS FOR SILENCING MYOC EXPRESSION MEYERING, SHABANA SHABBEER 1635 §103 Final Rejection Pending Oct 05, 2022
17937256 MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT MCKILLOP, JOHN CHARLES 1637 §102§103§112DPOther Non-Final OA Pending Sep 30, 2022
17995035 MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF SULLIVAN, STEPHANIE LAUREN 1635 §103 Final Rejection 32d overdue Pending Sep 29, 2022
17802004 G PROTEIN-COUPLED RECEPTOR 146 (GPR146) IRNA COMPOSITIONS AND METHODS OF USE THEREOF PERSONS, JENNA L 1637 §103§112 Non-Final OA 30d Pending Aug 24, 2022
17779706 SYNTHESIS OF 3 -RNA OLIGONUCLEOTIDES CREWS, JARET JAMES 1691 §103 Final Rejection 26d overdue Pending May 25, 2022
17743498 METHODS AND COMPOSITIONS FOR TREATING AN ANGIOTENSINOGEN- (AGT-) ASSOCIATED DISORDER GOMEZ RODRIGUEZ, JULIO WASHINGTON 1637 DPOther Non-Final OA Pending May 13, 2022
17736251 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES VANHORN, ABIGAIL LOUISE 1636 §103§112Other Non-Final OA 43d overdue Pending May 04, 2022
17683423 XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 DP Final Rejection 110d overdue Pending Mar 01, 2022
17668413 SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALLEN, SARAH ELIZABETH 1637 §102§103 Final Rejection Pending Feb 10, 2022
17619633 DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM MCKILLOP, JOHN CHARLES 1637 §112DP Final Rejection Pending Dec 16, 2021
17611761 ORAL DELIVERY OF OLIGONUCLEOTIDES TRAN, CHRISTINA L 1637 §103§112Other Final Rejection 49d Pending Nov 16, 2021

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