Prosecution Insights
Last updated: April 19, 2026

Alnylam Pharmaceuticals, Inc.

32 pending office actions

Portfolio Summary

32
Total Pending OAs
8
Final Rejections
24
Non-Final OAs

Pending Office Actions

App #TitleExaminerArt UnitStatusFiled
18637183 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE GIBBS, TERRA C 1635 Non-Final OA Apr 16, 2024
18427072 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION VANHORN, ABIGAIL LOUISE 1636 Final Rejection Jan 30, 2024
18385005 COMPOSITIONS AND METHODS FOR TREATING TRANSTHYRETIN (TTR) MEDIATED AMYLOIDOSIS MCKILLOP, JOHN CHARLES 1637 Non-Final OA Oct 30, 2023
18382562 METHODS OF TREATING TRANSTHYRETIN (TTR) MEDIATED AMYLOIDOSIS POLIAKOVA-GEORGAN, EKATERINA 1637 Non-Final OA Oct 23, 2023
18376217 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 Final Rejection Oct 03, 2023
18324191 METHODS AND COMPOSITIONS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION TRAN, CHRISTINA L 1637 Non-Final OA May 26, 2023
18302855 METHODS AND COMPOSITIONS FOR TREATING PRIMARY HYPEROXALURIA POLIAKOVA-GEORGAN, EKATERINA 1637 Non-Final OA Apr 19, 2023
18301089 PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF CHONG, KIMBERLY 1636 Non-Final OA Apr 14, 2023
18299220 METHODS FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES USING TRANSTHYRETIN (TTR) iRNA COMPOSITIONS GIBBS, TERRA C 1635 Non-Final OA Apr 12, 2023
18247314 SNCA IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SNCA-ASSOCIATED NEURODEGENERATIVE DISEASES GIBBS, TERRA C 1635 Non-Final OA Mar 30, 2023
18125167 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF POLIAKOVA-GEORGAN, EKATERINA 1637 Non-Final OA Mar 23, 2023
18044401 IRNA COMPOSITIONS AND METHODS FOR SILENCING GROWTH FACTOR RECEPTOR BOUND PROTEIN 10 (GRB10) OR GROWTH FACTOR RECEPTOR BOUND PROTEIN 14 (GRB14) IN THE LIVER ARIETI, RUTH SOPHIA 1635 Non-Final OA Mar 08, 2023
17773508 COMPOSITIONS AND METHODS FOR SILENCING DNAJB1-PRKACA FUSION GENE EXPRESSION VYAS, KEYUR ANILKUMAR 1637 Non-Final OA Feb 09, 2023
18007007 ATXN2 IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING ATXN2-ASSOCIATED NEURODEGENERATIVE DISEASES WHITEMAN, BRIAN A 1636 Non-Final OA Jan 26, 2023
18015202 Circular siRNAs TRAN, CHRISTINA L 1637 Non-Final OA Jan 09, 2023
18001813 ANAPLASTIC LYMPHOMA KINASE (ALK) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF SULLIVAN, STEPHANIE LAUREN 1635 Non-Final OA Dec 14, 2022
18077271 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION GIBBS, TERRA C 1635 Non-Final OA Dec 08, 2022
17982819 CHIRALLY-ENRICHED DOUBLE-STRANDED RNA AGENTS ANGELL, JON E 1637 Non-Final OA Nov 08, 2022
17974596 APOLIPOPROTEIN E (APOE) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF TRAN, CHRISTINA L 1637 Final Rejection Oct 27, 2022
17995568 COMPOSITIONS AND METHODS FOR SILENCING MYOC EXPRESSION MEYERING, SHABANA SHABBEER 1635 Non-Final OA Oct 05, 2022
17956882 ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF GIBBS, TERRA C 1635 Non-Final OA Sep 30, 2022
17995035 MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF SULLIVAN, STEPHANIE LAUREN 1635 Non-Final OA Sep 29, 2022
17945151 COMPOSITIONS AND METHODS FOR TREATING SUBJECTS HAVING A HETEROZYGOUS ALANINE-GLYOXYLATE AMINOTRANSFERASE GENE (AGXT) VARIANT HUDSON, AMY ROSE 1636 Non-Final OA Sep 15, 2022
17794637 LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 Final Rejection Jul 22, 2022
17779706 SYNTHESIS OF 3 -RNA OLIGONUCLEOTIDES CREWS, JARET JAMES 1691 Non-Final OA May 25, 2022
17736251 TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES VANHORN, ABIGAIL LOUISE 1636 Non-Final OA May 04, 2022
17774477 EXTRAHEPATIC DELIVERY VANHORN, ABIGAIL LOUISE 1636 Final Rejection May 04, 2022
17683423 XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF HUDSON, AMY ROSE 1636 Non-Final OA Mar 01, 2022
17672771 NEUROFILAMENT LIGHT CHAIN (NFL) AS A BIOMARKER FOR TRANSTHYRETIN AMYLOIDOSIS POLYNEUROPATHY TRAN, CHRISTINA L 1637 Final Rejection Feb 16, 2022
17668917 ENDOSOMAL CLEAVABLE LINKERS VANHORN, ABIGAIL LOUISE 1636 Final Rejection Feb 10, 2022
17668413 SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALLEN, SARAH ELIZABETH 1637 Non-Final OA Feb 10, 2022
17314909 AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF SHIN, DANA H 1635 Final Rejection May 07, 2021

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