Prosecution Insights
Prosecution Insights
Technology area: Biotechnology & Pharmaceuticals
374 pending office actions • 258 clients • 317 examiners • 119 art units • 0 of 374 (0%) have an AI response strategy ready • 351 patents granted in the last 365 days
WILSON SONSINI GOODRICH & ROSATI manages a massive portfolio in the Biotechnology & Pharmaceuticals sector, with 23600 career applications. The firm currently faces 319 pending office actions, reflecting the scale of its ongoing prosecution efforts. Its resolved allowance rate is 71.34 percent, a figure that represents its success in securing patents within a highly scrutinized and complex technical field. The firm averages 3.61 office actions per allowance, which is indicative of the intensive negotiation often required in biotechnology patenting.
This average of 3.61 suggests that the firm frequently navigates multiple rounds of rejection and amendment to achieve a grant. Given the volume of 23600 applications, the 71.34 percent allowance rate demonstrates a consistent ability to handle large scale intellectual property portfolios for clients in the life sciences industry. Practitioners can interpret the 319 pending office actions as a sign of a robust and active practice that remains deeply engaged with the USPTO. The firm's experience across 23600 career applications provides a significant depth of knowledge that supports its 71.34 percent success rate in one of the most challenging areas of patent law.
Based on the USPTO statutory response window for each pending office action. 115 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.
Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 115 of the docket's apps have a known mailing date.
Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.
| Bucket | Cases |
|---|---|
| §101 only | 5 (1%) |
| §101 + other | 56 (15%) |
| §103 only | 87 (23%) |
| §102 only | 6 (2%) |
| §112 only | 31 (8%) |
| Double-patenting only | 15 (4%) |
| Double-patenting + other | 54 (14%) |
| Multi-statute (no §101) | 114 (30%) |
| No statute on record | 6 (2%) |
How the docket's pending cases split across USPTO tech-center bands.
Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.
| Examiner | Apps on this docket | Allow rate | Interview lift |
|---|---|---|---|
| LEE, WILLIAM Y | 8 | 47.9% | +34.1% |
| ARIANI, KADE | 4 | 74.9% | +32.4% |
| PECKHAM, RICHARD GRANT | 4 | 68.1% | +35.1% |
| ANDERSON, REBECCA L | 4 | 73.4% | +23.6% |
| SCHLOOP, ALLISON ELIZABETH | 4 | 63.0% | +56.5% |
| ROBINSON, HOPE A | 3 | 67.7% | +43.1% |
| SHIAO, REI TSANG | 3 | 79.8% | -33.6% |
| TAYLOR, LIA ELAN | 3 | 64.4% | +29.4% |
| HUANG, GIGI GEORGIANA | 3 | 31.8% | +30.8% |
| WILDER, CYNTHIA B | 2 | 71.0% | +26.6% |
Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17497373 | TISSUE GRASPING DEVICES AND RELATED METHODS | PRONE, CHRISTOPHER D | 169d overdue |
| 17841267 | COMBINATIONS OF FLAVIVIRUS PROTEINS, PEPTIDE SEQUENCES, EPITOPES, AND METHODS AND USES THEREOF | CHEN, STACY BROWN | 154d overdue |
| 18254433 | METHODS FOR CLASSIFICATION OF LIVER DISEASE | HOPPE, EMMA RUTH | 146d overdue |
| 17963651 | SYSTEMS AND METHODS FOR ACCESS MANAGEMENT AND CLUSTERING OF GENOMIC, PHENOTYPE, AND DIAGNOSTIC DATA | MISIASZEK, AMBER ALTSCHUL | 111d overdue |
| 18418855 | VECTOR FOR CANCER TREATMENT | BATES, KEENAN ALEXANDER | 92d overdue |
| 18297328 | MEDICAL INSTRUMENT AND MEDICAL METHOD FOR LOCALIZED DRUG DELIVERY | BOSWORTH, KAMI A | 91d overdue |
| 17291580 | TWO-GENE VECTORS FOR GENERATING CAR-T CELLS AND USES THEREOF | AEDER, SEAN E | 80d overdue |
| 18835346 | SYSTEM FOR FORECASTING A MENTAL STATE OF A SUBJECT AND METHOD | JACKSON, JORDAN L | 72d overdue |
Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 18784718 | OPHTHALMIC COMPOSITION | LEE, WILLIAM Y | 10d overdue |
| 18114469 | ORAL PHARMACEUTICAL COMPOSITION COMPRISING ZONISAMIDE AND PROCESS OF PREPARATION THEREOF | HUANG, GIGI GEORGIANA | 10d overdue |
| 18572399 | ERK1/2 AND KRAS G12C INHIBITORS COMBINATION THERAPY | ANDERSON, REBECCA L | 4d overdue |
| 18054676 | CELL-FREE DNA SIZE DETECTION | SCHLOOP, ALLISON ELIZABETH | 9d |
| 18249886 | MULTISPECIFIC ANTIBODIES FOR TARGETING CD28 AND PD-L1 AND METHODS OF USE THEREOF | TAYLOR, LIA ELAN | 33d |
| 17934945 | PHARMACOLOGY OF VISUAL CYCLE MODULATORS | HUANG, GIGI GEORGIANA | 55d |
| 17894884 | OPHTHALMIC COMPOSITION | LEE, WILLIAM Y | 55d |
| 19552942 | USE OF 5-HYDROXYMETHYCYTOSINE OR 5-METHYLCYTOSINE FOR DISEASE DETECTION | WILDER, CYNTHIA B | — |
| Art Unit | Apps |
|---|---|
| 1682 | 12 |
| 1623 | 11 |
| 3783 | 10 |
| 1683 | 10 |
| 3791 | 8 |
| 1626 | 8 |
| 1681 | 6 |
| 1627 | 6 |
| 3795 | 6 |
| 1621 | 6 |
| App # | Title | Client | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|---|
| 19682032 | COMPOSITIONS FOR TARGETING MUSCLE CELLS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | PUTTLITZ, KARL J | 1646 | §103§112 | Non-Final OA | — | Pending | May 19, 2026 |
| 19559043 | METHODS OF DETERMINING VARIABILITY IN MOLECULAR ALTERATIONS | Ellison Institute, LLC | KIM, YOUNG J | 1681 | §103 | Final Rejection | — | Pending | Mar 06, 2026 |
| 19552942 | USE OF 5-HYDROXYMETHYCYTOSINE OR 5-METHYLCYTOSINE FOR DISEASE DETECTION | Biomodal Limited | WILDER, CYNTHIA B | 1681 | §101§103§112 | Non-Final OA | — | Pending | Feb 27, 2026 |
| 19540128 | INHIBITORS OF RIPK2 AND MEDICAL USES THEREOF | Odyssey Therapeutics, Inc. | CORNET, JEAN P | 1628 | §103 | Final Rejection | — | Pending | Feb 13, 2026 |
| 19452108 | METHODS AND SYSTEMS FOR PREDICTIVE ANALYSIS BY MASS SPECTROMETRY | Matterworks Inc. | LUCK, SEAN M | 2878 | §102§103§112 | Final Rejection | — | Pending | Jan 16, 2026 |
| 19415046 | PEPTIDE ANALOGS AND METHODS OF USING THE SAME | Kallyope, Inc. | CHANDRA, GYAN | 1674 | §103§112 | Non-Final OA | — | Pending | Dec 10, 2025 |
| 19379379 | SYSTEMS AND METHODS FOR DETERMINING ACTIONS DURING EMERGENCIES | Lifespot Technology, Inc. | WALLICK, STEPHANIE SHOSHANA | 3628 | §101§102§103 | Non-Final OA | — | Pending | Nov 04, 2025 |
| 19370240 | COMPOSITIONS AND METHODS FOR TREATING ACUTE RESPIRATORY DISTRESS SYNDROME | Direct Biologics, LLC | NIEBAUER, RONALD T | 1658 | §102§103§112DP | Non-Final OA | — | Pending | Oct 27, 2025 |
| 19357014 | A SYSTEM AND METHOD FOR ULTRASOUND-ENHANCED DELIVERY OF DRUGS | Sonikure Holdings Limited | FARRAR, LAUREN PENG | 3783 | §103 | Non-Final OA | 54d | Pending | Oct 13, 2025 |
| 19353137 | METHODS, SYSTEMS AND COMPOSITIONS FOR ANALYTE DETECTION | Cleancard Inc. | WILDER, CYNTHIA B | 1681 | §103 | Non-Final OA | — | Pending | Oct 08, 2025 |
| 19344306 | METHODS AND SYSTEMS FOR VOLUMETRIC IMAGING | Stellaromics, Inc. | CARTER, RICHARD BRUCE | 2485 | DP | Non-Final OA | — | Pending | Sep 29, 2025 |
| 19330712 | SENSOR-BASED MACHINE LEARNING IN A HEALTH PREDICTION ENVIRONMENT | Evidation Health, Inc. | MISIASZEK, AMBER ALTSCHUL | 3682 | §101§103 | Final Rejection | 71d | Pending | Sep 16, 2025 |
| 19307449 | HYDROCORTISONE ORAL LIQUID FORMULATIONS | Eton Pharmaceuticals, Inc. | PIHONAK, SARAH | 1627 | §103 | Final Rejection | — | Pending | Aug 22, 2025 |
| 19303640 | SYSTEMS AND METHODS FOR METADATA BASED PATH FINDING | Datawalk Spólka Akcyjna | HOANG, SON T | 2169 | §103Other | Non-Final OA | — | Pending | Aug 19, 2025 |
| 19303223 | PERSONALIZED WELLNESS SYSTEMS AND METHODS OF USE | Onikoroshi, LLC | KRIANGCHAIVECH, KETTIP | 1686 | §101§103Other | Final Rejection | 30d overdue | Pending | Aug 18, 2025 |
| 19296637 | METHODS AND SYSTEMS FOR GENERATING RECOMMENDATIONS FOR HEALTH AND WELLNESS | Docfully, Inc. | VAN DUZER, ALEXIS KIM | 3682 | §101§102§103 | Non-Final OA | — | Pending | Aug 11, 2025 |
| 19292344 | METHODS AND SYSTEMS FOR NEURAL STIMULATION VIA VISUAL, AUDITORY AND PERIPHERAL NERVE STIMULATIONS | Cognito Therapeutics, Inc. | MALAMUD, DEBORAH LESLIE | 3792 | §102§103§112 | Final Rejection | 20d | Pending | Aug 06, 2025 |
| 19274214 | DEEP LEARNING-BASED METHODS, DEVICES, AND SYSTEMS FOR PRENATAL TESTING | Nucleix Ltd. | PATEL, JAY M | 3681 | DP | Non-Final OA | — | Pending | Jul 18, 2025 |
| 19236732 | METHODS, COMPOSITONS AND SYSTEMS FOR ANALYTE DETECTION | Stellaromics, Inc. | SISSON, BRADLEY L | 1682 | §103§112Other | Final Rejection | 40d | Pending | Jun 12, 2025 |
| 19236720 | METHODS, COMPOSITONS AND SYSTEMS FOR ANALYTE DETECTION | Stellaromics, Inc. | SISSON, BRADLEY L | 1682 | §103 | Final Rejection | — | Pending | Jun 12, 2025 |
| 19219221 | SOLOR TRACKER AND CONTROL METHOD OF THE SOLAR TRACKER | P4Q Electronics S.L. | TRINH, THANH TRUC | 1726 | §103 | Non-Final OA | — | Pending | May 27, 2025 |
| 19211711 | MULTISPACE PARKING PAY STATIONS INCLUDING PAYMENT IMPROVEMENTS | Ips Group Inc. | VANDERHORST, MARIA VICTORIA | §101§103 | Non-Final OA | — | Pending | May 19, 2025 | |
| 19205306 | SYSTEMS AND METHODS FOR DATA QUALITY AND VALIDITY IMPROVEMENT IN EDUCATION INSTITUTIONAL, DEGREE, AND COURSE LICENSE MANAGEMENT | Woolf Inc. | HARRIS, CHRISTOPHER C | §101§112 | Non-Final OA | — | Pending | May 12, 2025 | |
| 19199682 | Methods and Systems for Evaluation of Lupus Based on Ancestry-Associated Molecular Pathways | Ampel Biosolutions, LLC | PAULSON, SHEETAL R. | 3615 | §101§102 | Final Rejection | — | Pending | May 06, 2025 |
| 19196360 | SYSTEMS AND METHODS FOR MEDICAL IMAGING GATEWAYS | Alara Imaging Inc. | HUANG, KAYLEE J | §101§102§103§112Other | Non-Final OA | — | Pending | May 01, 2025 | |
| 19190170 | SPECTROMETRY SYSTEMS WITH DECREASED LIGHT PATH | Scio Solutions Ltd. | NUR, ABDULLAHI | 2877 | DP | Non-Final OA | — | Pending | Apr 25, 2025 |
| 19184633 | SYSTEMS, METHODS, SOFTWARE, AND PLATFORMS FOR CLINICAL DECISION SUPPORT | Triaj, Inc. | EDOUARD, PATRICIA KELLY | 3683 | §101§103§112 | Non-Final OA | — | Pending | Apr 21, 2025 |
| 19113337 | USE OF AN EMULSIFIER DERIVED FROM RICINOLEIC ACID TO INCREASE THE ABSORPTION OF CALCIUM AND PHOSPHORUS IN THE DIGESTIVE TRACT OF FARM ANIMALS | Gfs Industria De Alimentação Animal Ltda | YOO, HONG THI | 1792 | §103§112 | Non-Final OA | — | Pending | Mar 19, 2025 |
| 19082681 | SYSTEMS AND METHODS FOR ROBOTIC ENDOSCOPE SYSTEM UTILIZING TOMOSYNTHESIS AND AUGMENTED FLUOROSCOPY | Noah Medical Corporation | LUU, TIMOTHY TUAN | §102§103 | Non-Final OA | — | Pending | Mar 18, 2025 | |
| 19082739 | SYSTEMS AND METHODS FOR ROBOTIC ENDOSCOPE BENDING SECTION | Noah Medical Corporation | SHARPLESS, CHRISTEN ALICIA | §102§103 | Non-Final OA | — | Pending | Mar 18, 2025 | |
| 19067593 | TEMPORARY VASCULAR SCAFFOLD AND SCORING DEVICE | Nfinium Vascular Technologies, LLC | RWEGO, KANKINDI | 3771 | §112Other | Non-Final OA | — | Pending | Feb 28, 2025 |
| 19058491 | SYSTEMS AND METHODS FOR CONTRAST-ENHANCED MRI | Subtle Medical, Inc. | WINDSOR, COURTNEY J | §112 | Non-Final OA | — | Pending | Feb 20, 2025 | |
| 19054472 | SYSTEMS AND METHODS FOR WASTEWATER HEAT RECOVERY | Epic Cleantec Inc. | ARANT, HARRY E | 3763 | §103 | Non-Final OA | 82d | Pending | Feb 14, 2025 |
| 19053307 | COMPOSITIONS AND METHODS FOR REDUCING GREENHOUSE GAS | Rumin8 Pty Ltd. | SWEENEY, MAURA ELIZABETH | 1791 | §103§112 | Non-Final OA | — | Pending | Feb 13, 2025 |
| 19049689 | METHOD FOR OBTAINING A LIGNOCELLULOSIC COMPOSITE MATERIAL AND COMPOSITE MATERIAL OBTAINED THEREOF | SAS Woodoo | SWANSON, ANDREW L | §102§103 | Non-Final OA | — | Pending | Feb 10, 2025 | |
| 19045764 | IMIDAZO[1,2-C]PYRIMIDINE DERIVATIVES AS PRC2 INHIBITORS FOR TREATING CANCER | Mirati Therapeutics, Inc. | SANCHEZ, JUSTIN CHRISTOPHER | 1622 | §112DP | Non-Final OA | — | Pending | Feb 05, 2025 |
| 19038867 | COMPOSITIONS COMPRISING CYSTEINE PRODRUGS AND METHODS USING THEREOF | Nature'S Fusions, LLC | ROSSI, JULIA ANNE LORRAIN | §103§112 | Non-Final OA | — | Pending | Jan 28, 2025 | |
| 19038117 | METHODS AND SYSTEMS FOR REMOTE OPERATION OF VEHICLE | Rotor Technologies, Inc. | HOLWERDA, STEPHEN | 3656 | §101§102§112 | Non-Final OA | — | Pending | Jan 27, 2025 |
| 19030518 | AMORPHOUS (A-POLYMORPHIC) PSILOCYBIN | Diamond Therapeutics Inc. | GONZALEZ, LUISALBERTO | 1624 | §103 | Final Rejection | — | Pending | Jan 17, 2025 |
| 19030061 | COMPOSITIONS AND METHODS FOR PRODUCING FOOD PRODUCTS WITH RECOMBINANT ANIMAL PROTEIN | Bond Pet Foods, Inc. | ROBINSON, HOPE A | 1652 | §112 | Non-Final OA | — | Pending | Jan 17, 2025 |
| 19025546 | SYSTEMS AND METHODS FOR DETERMINING DATABASE PERMISSIONS | Datawalk Spólka Akcyjna | SKHOUN, HICHAM | 2164 | §102§103 | Final Rejection | 52d overdue | Pending | Jan 16, 2025 |
| 19022841 | WEARABLE DEVICE TO COUNTERACT TREMOR | Equibands Inc. | LEBRON DE JESUS, GRACIELA NATALIA | 3786 | §102§103 | Non-Final OA | — | Pending | Jan 15, 2025 |
| 19018531 | SYSTEMS AND METHODS FOR NUCLEAR FUSION | Aquarius Energy, Inc. | GARNER, LILY CRABTREE | §101§102§103§112 | Non-Final OA | — | Pending | Jan 13, 2025 | |
| 19014986 | SYSTEMS AND METHODS FOR TRANSPORTING ITEMS WITHIN A NETWORK OF TUBULAR TRACK SYSTEMS | Tubular Network Inc. | TIGHE, BRENDAN P | §102§103 | Non-Final OA | — | Pending | Jan 09, 2025 | |
| 18992908 | WASTEWATER PROCESSING SYSTEMS AND METHODS | Eniswaterpure, LLC | VARMA, AKASH K | 1773 | §103 | Final Rejection | — | Pending | Jan 09, 2025 |
| 19001901 | SYSTEMS AND METHODS FOR ACCELERATING SPECT IMAGING | Subtle Medical, Inc. | CHAN, CAROL WANG | §102§103§112 | Non-Final OA | — | Pending | Dec 26, 2024 | |
| 18981846 | COMPOSITIONS AND METHODS FOR EPIGENETIC EDITING | Nchroma Bio, Inc. | ROBINSON, HOPE A | §103§112 | Non-Final OA | — | Pending | Dec 16, 2024 | |
| 18980218 | METHODS AND PRODUCTS FOR NUCLEIC ACID PRODUCTION AND DELIVERY | Factor Bioscience Inc. | LEONARD, ARTHUR S | §102§103§112DP | Non-Final OA | — | Pending | Dec 13, 2024 | |
| 18973406 | SYSTEMS AND METHODS FOR ADJUSTING VIEWING DIRECTION | Noah Medical Corporation | LUU, TIMOTHY TUAN | 3795 | §103 | Non-Final OA | — | Pending | Dec 09, 2024 |
| 18971494 | SYSTEMS AND METHODS FOR ROBOTIC BRONCHOSCOPY NAVIGATION | Noah Medical Corporation | WOO, JAE KYUN | 3795 | §102§103 | Non-Final OA | — | Pending | Dec 06, 2024 |
| 18958126 | METHODS FOR MAXIMUM JOINT PROBABILITY ASSIGNMENT TO SEQUENTIAL BINARY RANDOM VARIABLES IN QUADRATIC TIME COMPLEXITY | January, Inc. | BLANCHETTE, JOSHUA B | 3684 | §112 | Final Rejection | 35d overdue | Pending | Nov 25, 2024 |
| 18955505 | AKT1 MODULATORS | Alterome Therapeutics, Inc. | RODRIGUEZ-GARCIA, VALERIE | 1621 | §112 | Non-Final OA | — | Pending | Nov 21, 2024 |
| 18867628 | CRYSTAL FORMS OF TRIAZINE DIONE DERIVATIVE AND PREPARATION METHOD THEREFOR | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | KOSACK, JOSEPH R | §112 | Non-Final OA | — | Pending | Nov 20, 2024 | |
| 18951439 | SECURE ELECTRIC VEHICLE CHARGER AND SYSTEM INCORPORATING THEREOF | Eve Energy Ventures Inc. | WRIGHT, BRYAN F | 2497 | §103 | Non-Final OA | — | Pending | Nov 18, 2024 |
| 18951298 | METHODS AND APPARATUS FOR EVALUATING DEVELOPMENTAL CONDITIONS AND PROVIDING CONTROL OVER COVERAGE AND RELIABILITY | Cognoa, Inc. | WILLIAMS, TERESA S | §101§102§103 | Non-Final OA | — | Pending | Nov 18, 2024 | |
| 18947045 | THERAPEUTIC VARIANT ALPHA-2-MACROGLOBULIN COMPOSITIONS | Cytonics Corporation | NOAKES, SUZANNE MARIE | §102§112DP | Non-Final OA | — | Pending | Nov 14, 2024 | |
| 18948178 | METHODS AND SYSTEMS FOR GENERATING HIGH-CONTRAST ARRAYS | Atom Computing Inc. | KIM, ROBERT H | §102§103 | Non-Final OA | — | Pending | Nov 14, 2024 | |
| 18942248 | CRYSTALLINE FORMS OF A CANNABINOID RECEPTOR TYPE 1 (CB1) MODULATOR AND METHODS OF USE AND PREPARATION THEREOF | Anebulo Pharmaceuticals, Inc. | SEAMAN, D MARGARET M | §112DP | Non-Final OA | — | Pending | Nov 08, 2024 | |
| 18941418 | DEVICES FOR BIOLOGICAL ANALYSIS | Cellsbin, Inc. | UNDERWOOD, JARREAS C | 2877 | §103 | Final Rejection | — | Pending | Nov 08, 2024 |
| 18940597 | THERAPEUTIC USES OF GLP1R AGONISTS | Vtv Therapeutics LLC | BORI, IBRAHIM D | 1629 | §103§112DP | Non-Final OA | — | Pending | Nov 07, 2024 |
| 18938630 | MICROORGANISMS AND ARTIFICIAL ECOSYSTEMS FOR THE PRODUCTION OF PROTEIN, FOOD, AND USEFUL CO-PRODUCTS FROM C1 SUBSTRATES | Kiverdi, Inc. | ARIANI, KADE | §101§102§112Other | Non-Final OA | — | Pending | Nov 06, 2024 | |
| 18935201 | METHODS AND DEVICES FOR MEMBRANE CHARACTERIZATION WITH ULTRASOUND AND OPTICAL ILLUMINATION | Otonexus Medical Technologies, Inc. | IP, JASON M | 3797 | §103 | Final Rejection | 46d | Pending | Nov 01, 2024 |
| 18931558 | CHOLIX TOXIN-DERIVED FUSION MOLECULES FOR ORAL DELIVERY OF BIOLOGICALLY ACTIVE CARGO | Thornhill Therapeutics, Inc. | ZEMAN, ROBERT A | §102§103Other | Non-Final OA | — | Pending | Oct 30, 2024 | |
| 18928814 | BETA-LACTAM DERIVATIVES FOR THE TREATMENT OF DISEASES | Insilico Medicine Ip Limited | DAVIS, BRIAN J | §112DP | Non-Final OA | — | Pending | Oct 28, 2024 | |
| 18860464 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Retune Pharma Inc. | SOROUSH, ALI | 1629 | §112 | Non-Final OA | — | Pending | Oct 25, 2024 |
| 18926142 | TOXIN-DERIVED DELIVERY CONSTRUCTS | Thornhill Therapeutics, Inc. | TSAY, MARSHA M | §103DP | Non-Final OA | — | Pending | Oct 24, 2024 | |
| 18924896 | COMPLEX IMAGE DATA ANALYSIS USING ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING ALGORITHMS | Sirona Medical, Inc. | BAKER, CHARLOTTE M | §102 | Non-Final OA | — | Pending | Oct 23, 2024 | |
| 18921391 | ECG PATCH AND METHODS OF USE | Lifesignals, Inc. | DOWNEY, JOHN R | §102§103§112 | Non-Final OA | — | Pending | Oct 21, 2024 | |
| 18917796 | COMPOUNDS AND METHODS FOR MODULATING HER2 | Iambic Therapeutics, Inc. | SHIAO, REI TSANG | DP | Non-Final OA | — | Pending | Oct 16, 2024 | |
| 18913757 | METHODS AND PRODUCTS FOR TRANSFECTION | Factor Bioscience Inc. | NOBLE, MARCIA STEPHENS | DP | Non-Final OA | — | Pending | Oct 11, 2024 | |
| 18907033 | MACHINE LEARNING FOR OTITIS MEDIA DIAGNOSIS | Otonexus Medical Technologies, Inc. | STREGE, JOHN B | §103Other | Non-Final OA | — | Pending | Oct 04, 2024 | |
| 18903228 | INHIBITORS OF ADVANCED GLYCATION END PRODUCTS | Praetego Inc. | PECKHAM, RICHARD GRANT | §103§112DP | Non-Final OA | — | Pending | Oct 01, 2024 | |
| 18894460 | APPARATUS FOR MANIPULATION OF EAR DEVICES | Earplace Inc. | SHAH, JAY B | §102§103§112 | Non-Final OA | — | Pending | Sep 24, 2024 | |
| 18891790 | PHENOTYPE MEASUREMENT SYSTEMS AND METHODS | Fenologica Biosciences, Inc. | GILLIARD, DELOMIA L | §103DP | Non-Final OA | — | Pending | Sep 20, 2024 | |
| 18890248 | INHIBITORS OF MEK KINASE | Mosaica Medicines, Inc. | STOCKTON, LAURA LYNNE | DP | Non-Final OA | — | Pending | Sep 19, 2024 | |
| 18890562 | INTEGRATED PLATFORM FOR DIGITAL ASSET REGISTRATION, TRACKING AND VALIDATION | Figure Lending Corporation | SHARON, AYAL I | 3695 | §101§103 | Final Rejection | — | Pending | Sep 19, 2024 |
| 18883711 | ARTIFICIAL INTELLIGENCE PHYSICS-BASED MODELING OF CARDIAC PARAMETERS | Delbeat, Inc. | HAKALA, ALAN GREGORY | 2617 | §102§103 | Non-Final OA | 14d | Pending | Sep 12, 2024 |
| 18824159 | METHODS AND SYSTEMS FOR CHROMATOGRAPHIC DETERMINATION OF A METABOLOME | Park City Venture Partners, LLC | SANGHERA, STEVEN G.S. | 3684 | §101§102§103§112 | Final Rejection | 51d overdue | Pending | Sep 04, 2024 |
| 18823534 | MICROORGANISMS AND ARTIFICIAL ECOSYSTEMS FOR THE PRODUCTION OF PROTEIN, FOOD, AND USEFUL CO-PRODUCTS FROM C1 SUBSTRATES | Kiverdi, Inc. | ARIANI, KADE | §112DP | Non-Final OA | — | Pending | Sep 03, 2024 | |
| 18823526 | MICROORGANISMS AND ARTIFICIAL ECOSYSTEMS FOR THE PRODUCTION OF PROTEIN, FOOD, AND USEFUL CO-PRODUCTS FROM C1 SUBSTRATES | Kiverdi, Inc. | ARIANI, KADE | §112DP | Non-Final OA | — | Pending | Sep 03, 2024 | |
| 18821111 | SYSTEM FOR DIAGNOSING, TRACKING, AND PREDICTING RECOVERY PATTERNS IN PATIENTS WITH TRAUMATIC BRAIN INJURY | Mayo Foundation for Medical Education and Research | BODENDORF, ANDREW | 3715 | §101§102§103 | Non-Final OA | — | Pending | Aug 30, 2024 |
| 18819935 | BETA-LACTAMASE INHIBITORS | Venatorx Pharmaceuticals, Inc. | YOO, SUN JAE | 1621 | Other | Non-Final OA | — | Pending | Aug 29, 2024 |
| 18817943 | MEDIUM- OR MACRO-CYCLIC BENZYL-SUBSTITUTED HETEROCYCLE DERIVATIVES AND RELATED USES | Centessa Pharmaceuticals (Uk) Limited | WHITE, DAWANNA SHAR-DAY | §102§103§112DP | Non-Final OA | — | Pending | Aug 28, 2024 | |
| 18818407 | SURVEILLANCE SYSTEM AND METHODS FOR AUTOMATED WAREHOUSES | Nomagic sp z o.o. | ORTIZ ROMAN, DENISSE Y | 3627 | §103 | Final Rejection | 26d overdue | Pending | Aug 28, 2024 |
| 18818005 | Methods for Treating Neurodegenerative Disorders | Praetego Inc. | PECKHAM, RICHARD GRANT | §103§112DP | Non-Final OA | — | Pending | Aug 28, 2024 | |
| 18813959 | COMPOSITIONS AND METHODS FOR IMPROVING COGNITIVE FUNCTION | Diamond Therapeutics Inc. | COPPINS, JANET L | 1628 | §103 | Final Rejection | — | Pending | Aug 23, 2024 |
| 18814218 | EFFICIENT STORAGE AND RETRIEVAL OF SMALL OBJECTS | Tigris Data, Inc. | UDDIN, MD I | 2169 | §101§103 | Non-Final OA | — | Pending | Aug 23, 2024 |
| 18807599 | INTRANASAL DELIVERY DEVICES | Shin Nippon Biomedical Laboratories, Ltd. | MURPHY, VICTORIA | §103§112 | Non-Final OA | — | Pending | Aug 16, 2024 | |
| 18806109 | Unsupervised Machine Learning Methods | Ampel Biosolutions, LLC | DAUNER, JOSEPH G | 1682 | §102§103§112 | Final Rejection | 28d | Pending | Aug 15, 2024 |
| 18837846 | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF | Insilico Medicine Ip Limited | ROBINSON, MIKHAIL O'DONNEL | §103 | Non-Final OA | — | Pending | Aug 12, 2024 | |
| 18837847 | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF | Insilico Medicine Ip Limited | WHITE, DAWANNA SHAR-DAY | §103DP | Non-Final OA | — | Pending | Aug 12, 2024 | |
| 18799839 | APPARATUS FOR WAFER HANDLING AND ALIGNMENT | N&K Technology, Inc. | CORTES, HOWARD | 2118 | §102§103 | Non-Final OA | — | Pending | Aug 09, 2024 |
| 18794589 | CRYSTAL FORMS OF A POL1 INHIBITOR | Pimera, Inc. | KUCHARCZK, JED A | DP | Non-Final OA | — | Pending | Aug 05, 2024 | |
| 18835346 | SYSTEM FOR FORECASTING A MENTAL STATE OF A SUBJECT AND METHOD | Digital For Mental Health | JACKSON, JORDAN L | 2857 | §101§103 | Final Rejection | 72d overdue | Pending | Aug 01, 2024 |
| 18835167 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Mrja Therapeutics, Inc. | PECKHAM, RICHARD GRANT | §112 | Non-Final OA | — | Pending | Aug 01, 2024 | |
| 18785556 | METHODS AND COMPOSITIONS FOR TREATING POLYCYSTIC OVARY SYNDROME | Spruce Biosciences, Inc. | RAHMANI, NILOOFAR | §112DP | Non-Final OA | — | Pending | Jul 26, 2024 | |
| 18784718 | OPHTHALMIC COMPOSITION | Sydnexis, Inc. | LEE, WILLIAM Y | 1623 | §103 | Final Rejection | 10d overdue | Pending | Jul 25, 2024 |
| 18780961 | METHODS FOR HUMAN LEUKOCYTE ANTIGEN TYPING AND PHASING | Dovetail Genomics, LLC | POHNERT, STEVEN C | §101§103 | Non-Final OA | — | Pending | Jul 23, 2024 | |
| 18775447 | INTRALUMINAL SUPPORT STRUCTURE AND PROSTHETIC VALVE FOR THE SAME | Open Stent Solution SAS | HU, ANN M | §102§103§112 | Non-Final OA | — | Pending | Jul 17, 2024 | |
| 18774818 | Tubular Structures with Variable Support | Q'Apel Medical, Inc. | SWANSON, LEAH JENNINGS | §102§103§112DP | Non-Final OA | — | Pending | Jul 16, 2024 | |
| 18774776 | Tubular Structures with Variable Support | Q'Apel Medical, Inc. | SWANSON, LEAH JENNINGS | 3783 | §102§103DP | Non-Final OA | — | Pending | Jul 16, 2024 |
| 18768466 | Recovering Long-Range Linkage Information From Preserved Samples | Dovetail Genomics, LLC | GRAY, JESSICA | §103§112DP | Non-Final OA | — | Pending | Jul 10, 2024 | |
| 18763381 | OPHTHALMIC COMPOSITION AND DELIVERY DEVICE THEREOF | Sydnexis, Inc. | KALIHER, HANS CHRISTIAN | 3781 | §103§112 | Final Rejection | — | Pending | Jul 03, 2024 |
| 18763980 | PARTICLES AND METHODS OF ASSAYING | Seer, Inc. | FRITCHMAN, REBECCA M | 1758 | §103§112DP | Final Rejection | 88d overdue | Pending | Jul 03, 2024 |
| 18762386 | RELAXATION-BASED MAGNETIC RESONANCE THERMOMETRY WITH A LOW-FIELD SINGLE-SIDED MRI SCANNER | Promaxo, Inc. | JASANI, ASHISH SHIRISH | 3798 | §103 | Non-Final OA | 63d | Pending | Jul 02, 2024 |
| 18756287 | SYSTEMS AND METHODS FOR DETERMINING AND QUANTIFYING IMAGE DATA | Gauss Labs Inc. | LI, RUIPING | 2676 | §103 | Final Rejection | — | Pending | Jun 27, 2024 |
| 18725070 | PREPARATION OF A COMPOUND FOR THE TREATMENT OF GOUT OR HYPERURICEMIA | Arthrosi Therapeutics, Inc. | HERNANDEZ, JACKSON J | §102§103§112 | Non-Final OA | — | Pending | Jun 27, 2024 | |
| 18753922 | Secure Electric Vehicle Charger and System Incorporating Thereof | Eve Energy Ventures Inc. | WRIGHT, BRYAN F | 2497 | §103§112 | Final Rejection | 52d overdue | Pending | Jun 25, 2024 |
| 18752362 | Unsupervised Machine Learning Methods | Ampel Biosolutions, LLC | CLOW, LORI A | 1687 | §101§102§112 | Non-Final OA | — | Pending | Jun 24, 2024 |
| 18722528 | METHODS AND COMPOSITIONS FOR IMPROVED MOLECULAR THERAPIES OF MULTIGENIC DISEASES | Land Medicine Inc. | CANDELARIA, JULIANA IRENE | §103§112 | Non-Final OA | — | Pending | Jun 20, 2024 | |
| 18743649 | SINGLE-MOLECULE PEPTIDE SEQUENCING THROUGH MOLECULAR BARCODING AND EX-SITU ANALYSIS | Glyphic Biotechnologies, Inc. | PRIEST, AARON A | §103§112 | Non-Final OA | — | Pending | Jun 14, 2024 | |
| 18719695 | FUSED PYRROLIDINE PSYCHOPLASTOGENS AND USES THEREOF | Delix Therapeutics, Inc. | ARCORIA, PAUL JOSEPH | 1621 | §103 | Non-Final OA | — | Pending | Jun 13, 2024 |
| 18738282 | SYSTEMS AND METHODS FOR POSE ESTIMATION OF IMAGING SYSTEM | Noah Medical Corporation | SHENG, CHAO | 3797 | §103§112 | Final Rejection | — | Pending | Jun 10, 2024 |
| 18734772 | COMPOSITIONS AND METHODS FOR RNA SYNTHESIS | Linearx, Inc. | REGA, KYLE THOMAS | 1636 | §112 | Final Rejection | 9d | Pending | Jun 05, 2024 |
| 18716877 | PHOSPHITE DEHYDROGENASE AS A SELECTABLE MARKER FOR MITOCHONDRIAL TRANSFORMATION | Napigen, Inc. | DEVEAU ROSEN, JASON | 1662 | §103 | Final Rejection | 10d overdue | Pending | Jun 05, 2024 |
| 18732126 | SYSTEMS AND METHODS FOR ANALYZING A TARGET MOLECULE | Axbio Inc. | GIAMMONA, FRANCESCA FILIPPA | 1681 | §103 | Final Rejection | — | Pending | Jun 03, 2024 |
| 18714015 | CRYSTALLINE FORMS OF A COMPOUND FOR TREATING OR PREVENTING GOUT OR HYPERURICEMIA | Arthrosi Therapeutics, Inc. | GONZALEZ, LUISALBERTO | §102§112 | Non-Final OA | — | Pending | May 28, 2024 | |
| 18675757 | AGRICULTURAL SYSTEM FOR LOW AND HIGH-RESOLUTION SPOT SPRAYING AND METHOD FOR OPERATING SUCH A SYSTEM | Ecorobotix SA | LIU, JINGCHEN | 3741 | §102§103§112 | Final Rejection | — | Pending | May 28, 2024 |
| 18675540 | COMPOSITIONS AND METHODS FOR ARUNDO PLANT BIOMASS PRODUCTION | Hexas Biomass Inc. | GILLETT, JENNIFER ANN | 3647 | §102§103§112 | Non-Final OA | — | Pending | May 28, 2024 |
| 18672017 | LIGHT-BASED MEDICAL DEVICE | Illumisen, Inc. | CATTUNGAL, SANJAY | 3798 | §102Other | Non-Final OA | — | Pending | May 23, 2024 |
| 18668242 | Aortic Heart Valve Devices | Raghuveer Basude | PRESTON, REBECCA STRASZHEIM | §103§112 | Non-Final OA | — | Pending | May 19, 2024 | |
| 18667884 | TREATMENT OF RESTENOSIS USING TEMSIROLIMUS | Mercator Medsystems, Inc. | RAHMANI, NILOOFAR | §101§102§103§112DP | Non-Final OA | — | Pending | May 17, 2024 | |
| 18666047 | SHELF-STABLE FORMULATIONS OF BENZOYL PEROXIDE AND METHODS OF PRODUCING SAME | BLUE HILL TECHNOLOGIES LLC | DONOHUE, SEAN R | 1618 | §103 | Final Rejection | 105d overdue | Pending | May 16, 2024 |
| 18666699 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | Edgewise Therapeutics, Inc. | STOCKTON, LAURA LYNNE | §102§103§112 | Non-Final OA | — | Pending | May 16, 2024 | |
| 18664554 | METHODS AND COMPOSITIONS FOR TREATING CANCER | Onconova Therapeutics, Inc. | ANDERSON, REBECCA L | §103 | Non-Final OA | — | Pending | May 15, 2024 | |
| 18662754 | METHODS AND SYSTEMS FOR AUDIO SAMPLE QUALITY CONTROL | Clearspeed Inc. | SHAH, ANTIM G | 2693 | §103 | Non-Final OA | 38d overdue | Pending | May 13, 2024 |
| 18708947 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | Erasca, Inc. | ROMERO, KRISTEN WANG | §102§112 | Non-Final OA | — | Pending | May 09, 2024 | |
| 18659544 | MULTIFUNCTIONAL MOLECULES AND USES THEREOF | Marengo Therapeutics, Inc. | HOPKINS, SAMANTHA LAKE | §102§103§112DP | Non-Final OA | — | Pending | May 09, 2024 | |
| 18658491 | COMPACT AUTO-INJECTOR | Pirouette Pharma Inc. | SHAH, NILAY J | 3783 | §102§103 | Non-Final OA | — | Pending | May 08, 2024 |
| 18657531 | SYSTEMS AND METHODS FOR RESPONSIVE INSERTION AND RETRACTION OF ROBOTIC ENDOSCOPE | Noah Medical Corporation | BOICE, JAMES EDWARD | 3795 | §103Other | Final Rejection | 59d overdue | Pending | May 07, 2024 |
| 18656385 | ONCOSELECTIVE CANCER THERAPY | Kernal Biologics, Inc. | CHONG, KIMBERLY | §112 | Non-Final OA | — | Pending | May 06, 2024 | |
| 18656278 | SYSTEMS AND METHODS FOR STOOL CHARACTERIZATION AS NON-INVASIVE MEASURES OF DISEASE ACTIVITY | Cylinder Health, Inc. | RUIZ, JOSHUA DAMIAN | 3684 | §101 | Non-Final OA | 30d overdue | Pending | May 06, 2024 |
| 18652545 | PRESSURE SAFETY DEVICE FOR BAG VALVE MASK | Safebvm | DITMER, KATHRYN ELIZABETH | §101§103§112Other | Non-Final OA | — | Pending | May 01, 2024 | |
| 18649700 | ANALYZING PHENOTYPES OF CELLS | Deepcell, Inc. | LANTZ, KARSTEN FOSTER | 2664 | §103§112 | Non-Final OA | — | Pending | Apr 29, 2024 |
| 18704831 | MULTISPECIFIC ANTIBODIES FOR TREATING CD47-ASSOCIATED DISEASES | Virtuoso Binco, Inc. | ALLEN, MARIANNE P | §112 | Non-Final OA | — | Pending | Apr 25, 2024 | |
| 18704395 | IFENPRODIL SALTS AND THERAPEUTIC USES THEREOF | Algernon Pharmaceuticals Inc. | LADD, CAROLYN LOUISE | 1622 | §103 | Non-Final OA | — | Pending | Apr 24, 2024 |
| 18704366 | PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF | Insilico Medicine Ip Limited | O DELL, DAVID K | DP | Non-Final OA | — | Pending | Apr 24, 2024 | |
| 18702772 | METHIONINE ADENOSYLTRANSFERASE 2a (MAT2A) INHIBITORS AND USES THEREOF | Insilico Medicine Ip Limited | WILLIS, DOUGLAS M | §112DP | Non-Final OA | — | Pending | Apr 18, 2024 | |
| 18702652 | (S)-1-(1-ACRYLOYLPIPERIDIN-3-YL)-2-FLUORO-5,6,7,8,9,10-HEXAHYDROCYCLO HEPTA[B]INDOLE-4-CARBOXAMIDE, AND RELATED CRYSTALLINE FORMS, COMPOSITIONS, AND METHODS THEREOF | Vidya Therapeutics, Inc. | LEE, WILLIAM Y | 1623 | §102§103 | Non-Final OA | — | Pending | Apr 18, 2024 |
| 18637810 | COMPOSITIONS AND METHODS FOR NEUTRALIZING ANTIGENS | Pacagen, Inc. | XIAO, YAN | §112 | Non-Final OA | — | Pending | Apr 17, 2024 | |
| 18636423 | SYSTEMS AND METHODS FOR MULTI-CONTRAST MULTI-SCALE VISION TRANSFORMERS | Subtle Medical, Inc. | LY, TOMMY TAI | 3797 | §103§112 | Final Rejection | 43d overdue | Pending | Apr 16, 2024 |
| 18634598 | ACTIVE LEARNING FOR WEARABLE HEALTH SENSOR | Evidation Health, Inc. | SZUMNY, JONATHON A | 3686 | §112 | Non-Final OA | 4d overdue | Pending | Apr 12, 2024 |
| 18700232 | METHOD OF TREATING ADDICTION | Anebulo Pharmaceuticals, Inc. | IVANOVA, SVETLANA M | 1627 | §102§103 | Non-Final OA | — | Pending | Apr 10, 2024 |
| 18699841 | TYRO3 INHIBITORS | Halia Therapeutics, Inc. | KENYON, JOHN S | 1625 | §102§112 | Non-Final OA | — | Pending | Apr 09, 2024 |
| 18628411 | TIDAL VOLUME, PRESSURE, INSPIRATORY TIME, AND VENTILATION RATE MEASUREMENT DEVICE DURING MANUAL VENTILATION | Safebvm Corp. | SIPPEL, RACHEL T | §103§112 | Non-Final OA | — | Pending | Apr 05, 2024 | |
| 18626751 | TREATMENT OF HYPERTENSION BY RENAL VASCULAR DELIVERY OF GUANETHIDINE | Mercator Medsystems, Inc. | GRAY, PHILLIP A | §103 | Non-Final OA | — | Pending | Apr 04, 2024 | |
| 18618157 | METHODS FOR CATEGORIZING DISEASE OUTCOMES | Kosuke Yoshida | JONES, CHRISTINE MICHELLE | 1682 | §101§103§112DP | Non-Final OA | — | Pending | Mar 27, 2024 |
| 18614468 | METHODS AND SYSTEMS FOR EIGENSTATE PREPARATION OF A TARGET HAMILTONIAN ON A QUANTUM COMPUTER | 1QB Information Technologies Inc. | NGUYEN, CHAU T | §102 | Non-Final OA | — | Pending | Mar 22, 2024 | |
| 18612081 | METHODS AND SYSTEMS FOR DETERMINING SOURCES OF ANOMALIES IN MANUFACTURING PROCESSES | Gauss Labs Inc. | PATEL, JIGNESHKUMAR C | 2116 | §101§102§103 | Non-Final OA | — | Pending | Mar 21, 2024 |
| 18612795 | SYSTEMS AND METHODS FOR SAMPLE COLLECTION | Drawbridge Health, Inc. | TOMBERS, JOSEPH A | 3791 | §102§103§112 | Non-Final OA | 7d | Pending | Mar 21, 2024 |
| 18605303 | SYSTEMS AND METHODS FOR LASER-BASED MEDICAL DEVICE ILLUMINATION | Noah Medical Corporation | STARKEY, OLIVIA GRACE | 3795 | §103 | Non-Final OA | — | Pending | Mar 14, 2024 |
| 18691648 | METHOD FOR PREPARING STRUCTURALLY COLOURED FILMS AND PIGMENTS | Sparxell UK Limited | WIECZOREK, MICHAEL P | §102§103§112 | Non-Final OA | — | Pending | Mar 13, 2024 | |
| 18603124 | POLYNUCLEOTIDE CONSTRUCTS | Sirius Therapeutics, Inc. | BRETZ, COREY LANE | 1600 | §103DP | Non-Final OA | — | Pending | Mar 12, 2024 |
| 18599002 | STROMAL STEM CELLS | Orbsen Therapeutics Limited | KNIGHT, TERESA E | DP | Non-Final OA | — | Pending | Mar 07, 2024 | |
| 18595834 | B7H4-TARGETED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF | Mersana Therapeutics, Inc. | GODDARD, LAURA B | §101§103DP | Non-Final OA | — | Pending | Mar 05, 2024 | |
| 18594668 | METHODS AND COMPOSITIONS FOR DETECTION OF MUTANT NUCLEIC ACID SEQUENCES | Tataa Biocenter AB | JONES, CHRISTINE MICHELLE | 1682 | §112DP | Non-Final OA | — | Pending | Mar 04, 2024 |
| 18590521 | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE | Design Therapeutics, Inc. | MEAH, MOHAMMAD Y | 1652 | §112 | Non-Final OA | — | Pending | Feb 28, 2024 |
| 18589357 | MONITORING OF HEALTH CONDITIONS USING A REAL-TIME AND CONTINUOUS BLOOD PRESSURE MEASURING SYSTEM | Esperto Medical, Inc. | HEALY, NOAH MICHAEL | 3791 | §102§103§112 | Non-Final OA | 18d overdue | Pending | Feb 27, 2024 |
| 18685798 | QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE | Arthrosi Therapeutics, Inc. | ENGLISH, CONNOR KENNEDY | 1625 | §103 | Non-Final OA | — | Pending | Feb 22, 2024 |
| 18584397 | COMPOSITIONS AND METHODS FOR TRANSGENE EXPRESSION | Avirmax Biopharma Inc. | YU, DELPHINUS DOU YI | §102§103§112 | Non-Final OA | — | Pending | Feb 22, 2024 | |
| 18583069 | METHODS OF TREATING CELIAC DISEASE | Curemark, LLC | PAGUIO FRISING, MICHELLE F | 1651 | §103§112 | Non-Final OA | — | Pending | Feb 21, 2024 |
| 18583551 | BLOCKADE OF CD7 EXPRESSION AND CHIMERIC ANTIGEN RECEPTORS FOR IMMUNOTHERAPY OF T-CELL MALIGNANCIES | National University Of Singapore | KAUFMAN, CLAIRE M | §112DP | Non-Final OA | — | Pending | Feb 21, 2024 | |
| 18441446 | SMALL MOLECULE MODULATORS OF FERROPTOSIS | Arpeggio Biosciences, Inc. | SHIAO, REI TSANG | 1691 | §112 | Non-Final OA | — | Pending | Feb 14, 2024 |
| 18438060 | METHODS OF TREATING CONGENITAL ADRENAL HYPERPLASIA | Spruce Biosciences, Inc. | LEE, WILLIAM Y | 1623 | §103§112DP | Final Rejection | — | Pending | Feb 09, 2024 |
| 18436238 | SYSTEMS AND METHODS FOR PROCESS MONITORING AND CONTROL | Gauss Labs Inc. | SHAFAYET, MOHAMMED | 2893 | §101§102§103§112 | Non-Final OA | — | Pending | Feb 08, 2024 |
| 18436808 | TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES | Georgetown University | STOICA, ELLY GERALD | §112DP | Non-Final OA | — | Pending | Feb 08, 2024 | |
| 18681811 | METHOD FOR DETECTING MEDICAL CONDITIONS USING ANALYSIS OF VERY SMALL EMBRYONIC-LIKE STEM CELLS | 23Ikigai Pte. Ltd. | CHUNDURU, SURYAPRABHA | 1681 | §101§102§103Other | Non-Final OA | — | Pending | Feb 06, 2024 |
| 18681163 | ANTI-CORTICOTROPIN-RELEASING HORMONE ANTIBODIES AND USE IN CONGENITAL ADRENAL HYPERPLASIA | Hbm Alpha Therapeutics, Inc. | VAN DRUFF, SYDNEY | §112 | Non-Final OA | — | Pending | Feb 05, 2024 | |
| 18681207 | GROWTH HORMONE-RELEASING HORMONE PEPTIDES AND FORMULATIONS THEREOF | Rebalance Health, Inc. | VARADARAJ, ARCHANA | §103 | Non-Final OA | — | Pending | Feb 05, 2024 | |
| 18681021 | METHODS AND SYSTEMS FOR PRODUCING COMPOSITE MATERIALS | Applied Bioplastics Corp. | WOODWARD, ANA LUCRECIA | §102§103§112 | Non-Final OA | — | Pending | Feb 02, 2024 | |
| 18431347 | SYSTEMS AND METHODS FOR INDUCING MUSCLE CONTRACTION | Asayena, Inc. | KUO, JONATHAN T | 3792 | §103§112 | Final Rejection | 60d overdue | Pending | Feb 02, 2024 |
| 18294494 | PROCESS FOR POLYAMIDE SYNTHESIS | Design Therapeutics, Inc. | PECKHAM, RICHARD GRANT | 1627 | §102§112 | Non-Final OA | — | Pending | Feb 01, 2024 |
| 18425997 | SDC-2 EXOSOME COMPOSITIONS AND METHODS OF ISOLATION AND USE | Orbsen Therapeutics Limited | SPENCE, JENNIFER SUZANNE | 1633 | §101§103Other | Non-Final OA | 7d | Pending | Jan 29, 2024 |
| 18292890 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | Epirium Bio Inc. | CHENG, KAREN | 1623 | §102§112DP | Non-Final OA | — | Pending | Jan 26, 2024 |
| 18424169 | MODELING DENTAL STRUCTURES FROM DENTAL SCAN | Get-Grin Inc. | ROSARIO, DENNIS | 2676 | §102§103 | Non-Final OA | — | Pending | Jan 26, 2024 |
| 18424564 | METHODS AND SYSTEMS FOR PHASE GATES IN QUANTUM COMPUTERS | Universal Quantum Ltd | STOFFA, WYATT A | 2881 | §103 | Non-Final OA | 19d overdue | Pending | Jan 26, 2024 |
| 18292856 | PYRROLO[2,3-b]PYRIDINE PGDH INHIBITORS AND METHODS OF MAKING AND USING | Epirium Bio Inc. | LEE, WILLIAM Y | 1623 | §112 | Non-Final OA | — | Pending | Jan 26, 2024 |
| 18422976 | SALIVA PAIRED IMAGING TEST APPARATUS AND METHOD | Oral Genome Corp. | COLENA, TRACY CHING-TIAN | §103§112 | Non-Final OA | — | Pending | Jan 25, 2024 | |
| 18419926 | METHODS OF ADMINISTERING MONOMETHYL FUMARATE AND PRODRUGS THEREOF HAVING REDUCED SIDE EFFECTS | Arbor Pharmaceuticals, LLC | TOWNSLEY, SARA ELIZABETH | 1629 | §103§112 | Non-Final OA | — | Pending | Jan 23, 2024 |
| 18420123 | READING METHOD OF A LATERAL FLOW TEST | P4Q Health, S.L. | COLE, HOUSTON DAVID | §101§103 | Non-Final OA | — | Pending | Jan 23, 2024 | |
| 18418855 | VECTOR FOR CANCER TREATMENT | Cancer Research Technology Limited | BATES, KEENAN ALEXANDER | 1631 | §103§112 | Final Rejection | 92d overdue | Pending | Jan 22, 2024 |
| 18415394 | METHODS AND DEVICES FOR CONTINUOUS OPERATION OF A COLD-ATOM DEVICE USING A SEPARATE RESERVOIR ARRAY | Atom Computing Inc. | COOK, BRIAN S | 2187 | §103 | Non-Final OA | 100d overdue | Pending | Jan 17, 2024 |
| 18578663 | METHODS AND COMPOSITIONS FOR IMPROVING VISUAL FUNCTION IN OCULAR DISEASES AND DISORDERS | Onl Therapeutics, Inc. | COFFA, SERGIO | §103§112DP | Non-Final OA | — | Pending | Jan 11, 2024 | |
| 18407758 | DISTORTION CORRECTION OF LOW FIELD MAGNETIC RESONANCE IMAGES WITH PAIRED HIGH FIELD MAGNETIC RESONANCE IMAGES USING MACHINE LEARNING | Neuro42, Inc. | KAUR, JASPREET | 2662 | §103 | Final Rejection | 80d overdue | Pending | Jan 09, 2024 |
| 18406859 | SYSTEMS AND METHODS FOR COMBINED DETECTION OF GENETIC ALTERATIONS | Predicine, Inc. | HORLICK, KENNETH R | §103§112 | Non-Final OA | — | Pending | Jan 08, 2024 | |
| 18405378 | SYSTEMS AND METHODS FOR COOLING | Ferveret Inc. | CAI, CHARLES J | 2115 | §102§103§112 | Non-Final OA | — | Pending | Jan 05, 2024 |
| 18405952 | RECYCLING OF BATTERIES WITH A VACUUM CRUSHING-VAPORIZATION-COLLECTION SYSTEM | Evolve Renewable Materials, Inc. | VAN OUDENAREN, MATTHEW W | §103§112 | Non-Final OA | — | Pending | Jan 05, 2024 | |
| 18575016 | HEPARIN FROM MODIFIED MST CELLS AND METHODS OF MAKING AND USING | Tega Therapeutics, Inc. | MCKNIGHT, CIARA A | 1656 | §102§103Other | Non-Final OA | — | Pending | Dec 28, 2023 |
| 18574148 | REDUCTION OF ENDOTOXINS IN BACTERIAL PROTEIN PREPARATIONS | Kiverdi, Inc. | MORENO, LARK JULIA | 1793 | §102§103 | Non-Final OA | — | Pending | Dec 26, 2023 |
| 18395124 | PARTICLE-BASED BIOSEPARATION ASSAYS | Seer, Inc. | COLENA, TRACY CHING-TIAN | §102§103 | Non-Final OA | — | Pending | Dec 22, 2023 | |
| 18391803 | SYSTEMS AND METHODS FOR WORKFLOW GENERATION | Opentrons Labworks Inc. | WEI, ZENGPU | 2197 | §103 | Non-Final OA | — | Pending | Dec 21, 2023 |
| 18393292 | METHODS AND SYSTEMS FOR SOLVING AN INTEGER PROGRAMMING PROBLEM OR A MIXED-INTEGER PROGRAMMING PROBLEM USING A CIRCUIT-BASED CONTINUOUS-VARIABLE QUANTUM OPTICAL DEVICE | 1QB Information Technologies Inc. | KWON, JUN | §101§103 | Non-Final OA | — | Pending | Dec 21, 2023 | |
| 18392546 | SYSTEMS AND METHODS FOR PREPARING IMAGING AND ANALYZING CYTOLOGIC SAMPLES | Invenio Imaging, Inc. | YENTRAPATI, AVINASH | 2672 | §103 | Non-Final OA | — | Pending | Dec 21, 2023 |
| 18390285 | COMPUTER-IMPLEMENTED METHOD FOR IMPROVING QUERY EXECUTION IN RELATIONAL DATABASES NORMALIZED AT LEVEL 4 AND ABOVE | Datawalk Spólka Akcyjna | MARI VALCARCEL, FERNANDO MARIANO | 2159 | §103 | Final Rejection | 74d overdue | Pending | Dec 20, 2023 |
| 18572399 | ERK1/2 AND KRAS G12C INHIBITORS COMBINATION THERAPY | Erasca, Inc. | ANDERSON, REBECCA L | 1626 | §103§112Other | Non-Final OA | 4d overdue | Pending | Dec 20, 2023 |
| 18572412 | SHP2 AND CDK4/6 INHIBITORS COMBINATION THERAPIES FOR THE TREATMENT OF CANCER | Erasca, Inc. | KUCKLA, ANNA GRACE | 1626 | §103Other | Non-Final OA | 19d overdue | Pending | Dec 20, 2023 |
| 18572087 | METHODS AND SYSTEMS FOR MACHINE LEARNING ANALYSIS OF INFLAMMATORY SKIN DISEASES | Ampel Biosolutions, LLC | SKIBINSKY, ANNA | 1635 | §101§103§112 | Final Rejection | — | Pending | Dec 19, 2023 |
| 18572148 | System and Method for Determining a Stool Condition | Dieta Inc. | MAHROUKA, WASSIM | 2665 | §101§103 | Final Rejection | 66d overdue | Pending | Dec 19, 2023 |
| 18529530 | PLATFORMS FOR CONDUCTING VIRTUAL TRIALS | Cancer Commons | KANAAN, LIZA TONY | 3683 | §101§103 | Non-Final OA | 28d | Pending | Dec 05, 2023 |
| 18512856 | NANOPORE PROTEOMICS | Rijksuniversiteit Groningen | QIAN, SHIZHI | 1798 | §103§112 | Non-Final OA | — | Pending | Nov 17, 2023 |
| 18511328 | SYSTEMS AND METHODS FOR REAL-TIME SYSTEMATIC HEALTH CARE | Tad Health Inc. | EGLOFF, PETER RICHARD | 3715 | §101 | Non-Final OA | 34d | Pending | Nov 16, 2023 |
| 18507807 | METHODS AND SYSTEMS FOR NUCLEIC ACID ISOLATION | Seek Labs, Inc. | BORTOLI, JONATHAN | 1797 | §102§103§112 | Non-Final OA | — | Pending | Nov 13, 2023 |
| 18506287 | N6-ADENOSINE-METHYLTRANSFERASE INHIBITORS IN CANCER TREATMENT | UNIVERSITY OF ZURICH | SHIAO, REI TSANG | 1691 | §102§103 | Non-Final OA | — | Pending | Nov 10, 2023 |
| 18506464 | METHODS AND COMPOSITIONS FOR IDENTIFYING VIRAL SEQUENCES | Decode Cure Limited | BELLECOURT, MICHAEL JOHN ALLEN | 1671 | §102§103§112 | Non-Final OA | — | Pending | Nov 10, 2023 |
| 18502595 | PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Siolta Therapeutics, Inc. | ARIANI, KADE | 1651 | — | Non-Final OA | — | Pending | Nov 06, 2023 |
| 18501238 | 5-HT2A AND/OR 5-HT2C RECEPTOR AGONISTS | Diamond Therapeutics Inc. | HABTE, KAHSAY | 1624 | §102§112 | Non-Final OA | — | Pending | Nov 03, 2023 |
| 18289399 | PHARMACEUTICAL COMPOSITION FOR USE IN TREATING CEREBRAL INFARCTION | Corxel Pharmaceuticals Hong Kong Limited | RAO, PADMAJA S | 1627 | §103DP | Final Rejection | 12d | Pending | Nov 03, 2023 |
| 18386765 | METHODS AND SYSTEMS FOR SHAPING MAGNETICS FIELDS TO ALIGN FORCES ON MAGNETIC PARTICLES FOR PATIENT ANATOMY AND MOTION | Otomagnetics, Inc. | DECASTRO, ARIANA JOY LACAY | §101§103§112 | Non-Final OA | — | Pending | Nov 03, 2023 | |
| 18501724 | METHODS AND COMPOSITIONS USING AN ENGINEERED RELEASE FACTOR | Opentrons Labworks Inc. | MULDER, SCOTT EVAN | 1656 | §102§103§112 | Non-Final OA | 26d | Pending | Nov 03, 2023 |
| 18500846 | SYSTEMS AND METHODS FOR AN AUTONOMOUS RIPPER | Aim Intelligent Machines, Inc. | JONES, JODI MARIE | 3666 | §103 | Non-Final OA | — | Pending | Nov 02, 2023 |
| 18491744 | EXTRACELLULAR VESICLES LOADED WITH STRUCTURAL BIOMOLECULES | Spot Biosystems Ltd. | HUDSON, AMY ROSE | 1636 | §102§103§112 | Non-Final OA | — | Pending | Oct 20, 2023 |
| 18555450 | NANOSCALE REACTION CHAMBERS AND METHODS OF USING THE SAME | Partillion Bioscience Corporation | GORDON, BRIAN R | 1798 | §101§112 | Non-Final OA | — | Pending | Oct 13, 2023 |
| 18379142 | METHODS FOR THE TREATMENT OF DIABETIC RETINOPATHY AND OTHER OPHTHALMIC DISEASES | Acucela Inc. | JAVANMARD, SAHAR | 1622 | §103Other | Non-Final OA | 56d | Pending | Oct 11, 2023 |
| 18554283 | TREATMENT OF CANCER WITH KDM4 INHIBITORS | Tachyon Therapeutics, Inc. | RZECZYCKI, PHILLIP MATTHEW | 1624 | §102§103§112DP | Non-Final OA | — | Pending | Oct 06, 2023 |
| 18482767 | COMPOSITIONS AND METHODS FOR OCULAR TRANSGENE EXPRESSION | Avirmax Biopharma Inc. | TAKENAKA, RISA | 1632 | §101§103§112 | Non-Final OA | — | Pending | Oct 06, 2023 |
| 18482789 | Functionalized Surfaces for Conversion of Carbon Dioxide | Prometheus Fuels, Inc. | WONG, EDNA | 1795 | §103§112 | Non-Final OA | — | Pending | Oct 06, 2023 |
| 18554174 | METHODS AND SYSTEMS FOR ANALYZING COMPLEX GENOMIC REGIONS | Rprd Diagnostics, LLC | CASH, KAILEY ELIZABETH | 1683 | §103§112DP | Non-Final OA | 82d | Pending | Oct 05, 2023 |
| 18285812 | GPR119 AGONISTS | Kallyope, Inc. | REILLY, SOPHIA JANE | 1627 | §112 | Non-Final OA | 30d | Pending | Oct 05, 2023 |
| 18479335 | INTRANASAL DHE FOR THE TREATMENT OF HEADACHE | Satsuma Pharmaceuticals, Inc. | HAGHIGHATIAN, MINA | 1616 | DP | Non-Final OA | — | Pending | Oct 02, 2023 |
| 18473089 | THREE-DIMENSIONAL ORTHOSES HAVING MULTIPLE ADJUSTMENT FEATURES AND METHODS FOR THEIR MANUFACTURE AND USE | Osteoid Saglik Teknolojileri A.S. | NELSON, KERI JESSICA | 3786 | §103 | Non-Final OA | — | Pending | Sep 22, 2023 |
| 18550428 | BIOCERAMIC COMPOSITIONS FOR CANCER RECOVERY | Multiple Energy Technologies LLC | COLLINS, SEAN W | 3794 | §103§112 | Non-Final OA | 2d overdue | Pending | Sep 13, 2023 |
| 18466675 | MICROBIOME IDENTIFICATION AND BACTERIOPHAGE FORMULATIONS | Parallel Health, Inc. | GRIZER, CASSANDRA SENN | 1672 | §103§112 | Final Rejection | 5d overdue | Pending | Sep 13, 2023 |
| 18462571 | PROCESSES AND APPARATUS FOR EXTRACTION OF SUBSTANCES AND ENRICHED EXTRACTS FROM PLANT MATERIAL | Biomass Oil Separation Solutions, LLC | RAMOS LEWIS, JOSMALEN MILAGROS | 1621 | §102§103 | Non-Final OA | — | Pending | Sep 07, 2023 |
| 18462365 | METHODS AND SYSTEMS FOR DROPLET MANIPULATION | Volta Labs, Inc. | SALMON, KATHERINE D | 1682 | §102§112 | Non-Final OA | — | Pending | Sep 06, 2023 |
| 18461776 | 5-HT RECEPTOR AGONIST TITRATION | Diamond Therapeutics Inc. | BAILEY, STEVEN WILLIAM | §101§102§103§112 | Non-Final OA | — | Pending | Sep 06, 2023 | |
| 18461368 | ENGINEERED IMMUNE CELL THERAPIES | Factor Bioscience Inc. | VANHORN, ABIGAIL LOUISE | 1636 | §103§112DP | Final Rejection | 9d overdue | Pending | Sep 05, 2023 |
| 18456737 | MEDICAL FLUID INJECTION APPARATUS AND METHOD WITH DETACHABLE PATCH AND MONITORING | Enable Injections, Inc. | FREHE, WILLIAM R | 3783 | §103 | Final Rejection | — | Pending | Aug 28, 2023 |
| 18453798 | COMPOUNDS AND METHODS FOR MODULATING HER2 | Iambic Therapeutics, Inc. | PATEL, SAGAR S | 1626 | §112DP | Final Rejection | 17d overdue | Pending | Aug 22, 2023 |
| 18453211 | IMMORTALIZED CELL LINE FOR ENGINEERED SYNTHETIC LEATHER | Vitrolabs Inc. | KHAN, AMINA S | 1761 | §103 | Non-Final OA | — | Pending | Aug 21, 2023 |
| 18452480 | METHODS, SYSTEMS, AND MEDIA METHOD APPLYING MACHINE LEARNING TO CHEMICAL MAPPING DATA FOR RNA TERTIARY STRUCTURE PREDICTION | Atomic AI, Inc. | PULLIAM, JOSEPH CONSTANTINE | §101§103§112 | Non-Final OA | — | Pending | Aug 18, 2023 | |
| 18546941 | TYK2 INHIBITORS AND USES THEREOF | Sudo Biosciences Limited | MOORE, SUSANNA | 1624 | §112Other | Final Rejection | — | Pending | Aug 17, 2023 |
| 18450775 | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE | Design Therapeutics, Inc. | SAEED, KAMAL A | 1626 | §103 | Non-Final OA | — | Pending | Aug 16, 2023 |
| 17759944 | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE | Design Therapeutics, Inc. | HAVLIN, ROBERT H | 1626 | §102 | Non-Final OA | 71d | Pending | Aug 10, 2023 |
| 18361357 | IL-2 PROCYTOKINE ANTIBODY FUSION PROTEINS | Proviva Therapeutics (Hong Kong) Limited | TAYLOR, LIA ELAN | 1641 | §103§112DP | Non-Final OA | — | Pending | Jul 28, 2023 |
| 18227071 | PUMP-CONNECTABLE ANALYTE SENSING CANNULA | Pacific Diabetes Technologies Inc. | NICHOLS, CHARLES W | 3783 | §103 | Non-Final OA | — | Pending | Jul 27, 2023 |
| 18358762 | METHODS AND SYSTEMS FOR AUTOMATED PNEUMATIC OTOSCOPY | Otonexus Medical Technologies, Inc. | YOON, CHANEL J | 3791 | §103 | Non-Final OA | — | Pending | Jul 25, 2023 |
| 18262787 | NEK7 INHIBITORS | Halia Therapeutics, Inc. | VAJDA, KRISTIN ANN | 1622 | §112 | Non-Final OA | — | Pending | Jul 25, 2023 |
| 18358886 | USE OF AN EMULSIFIER DERIVED FROM RICINOLEIC ACID TO INCREASE THE ABSORPTION OF CALCIUM AND PHOSPHORUS IN THE DIGESTIVE TRACT OF FARM ANIMALS | Gfsa Industria De Alimentação Animal Ltda | HUANG, GIGI GEORGIANA | 1613 | §102§103§112DP | Non-Final OA | — | Pending | Jul 25, 2023 |
| 18356688 | PLATELET ALPHA-GRANULES FOR DELIVERY OF MULTIPLE PROTEINS | Csts Health Care Inc. | BOWLES, DAVID PAUL | 1654 | §103§112 | Non-Final OA | 30d | Pending | Jul 21, 2023 |
| 18356949 | ENHANCEMENT OF ADOPTIVE CELL TRANSFER | Cellvie Inc. | WESTON, ALYSSA G | 1633 | §102§103 | Final Rejection | 16d overdue | Pending | Jul 21, 2023 |
| 18354506 | SYSTEMS AND METHODS FOR REAL-TIME SEARCH BASED GENERATIVE ARTIFICIAL INTELLIGENCE | SuSea, Inc. | RAMIREZ BRAVO, BEATRIZ A | 2146 | §103 | Non-Final OA | 73d overdue | Pending | Jul 18, 2023 |
| 18000102 | PREPARATION METHOD FOR (S)-2-AMINO-3-(4-(2,3-DIMETHYLPYRIDIN-4-YL)PHENYL)METHYL PROPIONATE DIACID SALT | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | ANDERSON, REBECCA L | 1626 | Other | Final Rejection | — | Pending | Jul 17, 2023 |
| 18000099 | METHOD FOR PREPARING GLP-1 RECEPTOR AGONIST | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | YOO, SUN JAE | 1621 | §102§112 | Non-Final OA | — | Pending | Jul 17, 2023 |
| 18000108 | METHOD FOR PREPARING GLP-1 RECEPTOR AGONIST FREE BASE | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | ANDERSON, REBECCA L | 1626 | §112 | Non-Final OA | — | Pending | Jul 17, 2023 |
| 18347922 | METHODS AND SYSTEMS OF PROCESSING COMPLEX DATA SETS USING ARTIFICIAL INTELLIGENCE AND DECONVOLUTION | Cofactor Genomics, Inc. | LEVERETT, MARY CHANG | §102§103DP | Non-Final OA | — | Pending | Jul 06, 2023 | |
| 18340765 | ORAL DELIVERY OF THERAPEUTIC MAMMALIAN CELLS | Direct Biologics, LLC | MCCORMICK, CATHERINE LYNN | 1638 | Other | Non-Final OA | 54d | Pending | Jun 23, 2023 |
| 18212477 | LONG-LIVED INSULIN DELIVERY CANNULA | Pacific Diabetes Technologies Inc. | STIMPERT, PHILIP EARL | 3783 | §102§103§112 | Final Rejection | 5d overdue | Pending | Jun 21, 2023 |
| 18268936 | BINDER MOLECULES WITH HIGH AFFINITY AND/ OR SPECIFICITY AND METHODS OF MAKING AND USE THEREOF | Alamar Biosciences, Inc. | OLSON, ALEXANDRA NADINE | 1684 | §102§103§112 | Non-Final OA | — | Pending | Jun 21, 2023 |
| 18258714 | SYSTEMS AND METHODS FOR PRESERVATION OF A CERVICOVAGINAL FLUID SAMPLE | NextGen Jane, Inc. | MCCORMACK, ERIN KATHLEEN | 3791 | §103§112 | Non-Final OA | 10d overdue | Pending | Jun 21, 2023 |
| 18336201 | SYSTEMS AND METHODS FOR IDENTIFYING AND DISTINGUISHING GENETIC SAMPLES | Revere Biosensors, LLC | CROW, ROBERT THOMAS | 1683 | §103DP | Final Rejection | 14d | Pending | Jun 16, 2023 |
| 18266970 | OLIGONUCLEOTIDE ANALOGUE THERAPEUTICS FOR TREATMENT OF NEUROMUSCULAR DISEASE | Neubase Therapeutics, Inc. | HASTINGS, ALISON AZAR | 1627 | §102§103§112Other | Non-Final OA | 4d overdue | Pending | Jun 13, 2023 |
| 18257273 | PHARMACEUTICAL FORMULATIONS OF A PHENOLIC TRPV1 AGONIST PRODRUG | Vp Asset Holdings, LLC | BARSKY, JARED | 1628 | §103DPOther | Final Rejection | — | Pending | Jun 13, 2023 |
| 18257272 | CRYSTALLINE FORM OF A PHENOLIC TRPV1 AGONIST PRODRUG | Vp Asset Holdings LLC | RICCI, CRAIG D | 1611 | §102 | Non-Final OA | — | Pending | Jun 13, 2023 |
| 18266793 | KINASE INHIBITORS AND USES THEREOF | Mosaica Medicines, Inc. | ENGLISH, CONNOR KENNEDY | 1625 | §112 | Non-Final OA | — | Pending | Jun 12, 2023 |
| 18256276 | HALF-LIFE EXTENDING COMPOSITIONS AND METHODS | Janux Therapeutics, Inc. | SAOUD, CHRISTINE J | 1645 | DP | Final Rejection | 37d overdue | Pending | Jun 07, 2023 |
| 18328598 | NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF | Factor Bioscience Inc. | ZHU, JIANJIAN | 1631 | §103 | Final Rejection | 22d | Pending | Jun 02, 2023 |
| 18327740 | METHOD OF TREATING SCHIZOPHRENIA OR SCHIZOPHRENIFORM DISORDER | Curemark, LLC | BROWE, DAVID | 1617 | §103Other | Non-Final OA | 62d | Pending | Jun 01, 2023 |
| 18255227 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Neupharma, Inc. | LEE, CHIHYI NMN | 1628 | §102§112DP | Non-Final OA | — | Pending | May 31, 2023 |
| 18202423 | SYSTEMS AND METHODS FOR DETECTING GENETIC ALTERATIONS | Predicine, Inc. | SWITZER, JULIET CAROLINE | 1682 | §101§103Other | Non-Final OA | 50d overdue | Pending | May 26, 2023 |
| 18254433 | METHODS FOR CLASSIFICATION OF LIVER DISEASE | Tensor Biosciences, Inc. | HOPPE, EMMA RUTH | 1683 | §101§102§103§112Other | Non-Final OA | 146d overdue | Pending | May 25, 2023 |
| 18038542 | MODULAR TEXTILE RECYCLING SYSTEM AND PROCESS | Ravel Holdings, Inc. | ROSEBACH, CHRISTINA H.W. | 1766 | §103§112 | Final Rejection | 49d overdue | Pending | May 24, 2023 |
| 18318563 | METHODS AND SYSTEMS FOR ANALYSIS OF MASS SPECTROMETRY DATA | Seer, Inc. | HILL, GRACELYN MARKHAM | 2125 | §101§102§103 | Non-Final OA | — | Pending | May 16, 2023 |
| 18252611 | MAGL INHIBITORS | H. Lundbeck A/S | NOLAN, JASON MICHAEL | 1623 | Other | Final Rejection | — | Pending | May 11, 2023 |
| 18195761 | Bag System Containing a Nutrient Composition Comprising Whole Food Sole Source Meal | Kate Farms, Inc. | JUSTICE, GINA CHIEUN YU | 1617 | §103§112Other | Final Rejection | 45d overdue | Pending | May 10, 2023 |
| 18315025 | METHODS AND SYSTEMS FOR SAMPLE NORMALIZATION | Accuragen Holdings Limited | SCHLOOP, ALLISON ELIZABETH | 1682 | §101§112 | Non-Final OA | — | Pending | May 10, 2023 |
| 18314090 | TUMOR ACTIVATED MULTISPECIFIC ANTIBODIES FOR TARGETING CD28 AND PD-L1 AND METHODS OF USE THEREOF | Janux Therapeutics, Inc. | LEE, YIE CHIA | 1642 | §112Other | Non-Final OA | — | Pending | May 08, 2023 |
| 18314077 | COMPOSITIONS AND METHODS RELATED TO TUMOR ACTIVATED ANTIBODIES TARGETING PSMA AND EFFECTOR CELL ANTIGENS | Janux Therapeutics, Inc. | CUNNINGCHEN, KATHLEEN MARY | 1646 | §112Other | Final Rejection | 38d overdue | Pending | May 08, 2023 |
| 18313146 | METHODS FOR DETECTION OF NUCLEOTIDE MODIFICATION | BLUECAT IP LIMITED | GIAMMONA, FRANCESCA FILIPPA | 1681 | §103Other | Final Rejection | 30d overdue | Pending | May 05, 2023 |
| 18308318 | METHODS AND COMPOSITIONS RELATING TO BIOMARKERS FOR NEURODEGENERATIVE DISEASES | Anacalypsis Therapeutics, Ike | BORGEEST, CHRISTINA M | 1675 | §101§102§103§112 | Non-Final OA | — | Pending | Apr 27, 2023 |
| 18305292 | COILED COIL IMMUNOGLOBULIN FUSION PROTEINS AND COMPOSITIONS THEREOF | The Scripps Research Institute | NATARAJAN, MEERA | 1643 | §102 | Non-Final OA | — | Pending | Apr 21, 2023 |
| 18249944 | TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH INHIBITORS OF MENIN | Kura Oncology, Inc. | SHOWALTER, ALEXANDER KEITH | 1629 | §103Other | Final Rejection | — | Pending | Apr 20, 2023 |
| 18249879 | ANTIBODIES TARGETING HER2 AND CD3 AND USES THEREOF | Janux Therapeutics, Inc. | FAUST, AMBER KATHLEEN | 1643 | §103DPOther | Final Rejection | 61d | Pending | Apr 20, 2023 |
| 18249886 | MULTISPECIFIC ANTIBODIES FOR TARGETING CD28 AND PD-L1 AND METHODS OF USE THEREOF | Janux Therapeutics, Inc. | TAYLOR, LIA ELAN | 1641 | §103§112 | Final Rejection | 33d | Pending | Apr 20, 2023 |
| 18302721 | POLYPEPTIDES | Sorriso Pharmaceuticals, Inc. | SANG, HONG | 1646 | DP | Non-Final OA | — | Pending | Apr 18, 2023 |
| 18301361 | METHODS FOR THE TREATMENT OF PRESBYOPIA | Lenz Therapeutics Operations, Inc. | WILSON, JERICA KATLYNN | 1621 | DP | Final Rejection | 49d overdue | Pending | Apr 17, 2023 |
| 18134854 | COMPOSITIONS AND METHODS FOR THE PREVENTION OF TYPE I HYPERSENSITIVITY REACTIONS | Iggenix, Inc. | HAMA, JOANNE | 1647 | §103 | Non-Final OA | 25d overdue | Pending | Apr 14, 2023 |
| 18297328 | MEDICAL INSTRUMENT AND MEDICAL METHOD FOR LOCALIZED DRUG DELIVERY | Mercator Medsystems, Inc. | BOSWORTH, KAMI A | 3783 | §103§112 | Final Rejection | 91d overdue | Pending | Apr 07, 2023 |
| 18297574 | METHOD AND SYSTEM FOR OPERATING A ROBOTIC DEVICE | Tombot, Inc. | LANDEEN, BROGAN RANE | 3791 | §103§112 | Non-Final OA | — | Pending | Apr 07, 2023 |
| 18191792 | COMPOSITIONS AND METHODS FOR DETECTING RARE SEQUENCE VARIANTS | Accuragen Holdings Limited | FLINDERS, JEREMY C | 1684 | §102§103DP | Non-Final OA | — | Pending | Mar 28, 2023 |
| 18186146 | BIOPSY SYSTEM FOR ENHANCED TISSUE HARVESTING | Data Driven Diagnostic Sciences, Inc., Dba D3Sciences | DOUGHERTY, SEAN PATRICK | 3791 | §102§103§112 | Non-Final OA | 62d | Pending | Mar 17, 2023 |
| 18185662 | SYSTEMS AND METHODS FOR NUCLEAR FUSION | Aquarius Energy, Inc. | GARNER, LILY CRABTREE | 3646 | §101§102§112 | Non-Final OA | 50d | Pending | Mar 17, 2023 |
| 18245410 | TISSUE GRASPING DEVICES AND RELATED METHODS | Medfree, Inc. | LOPEZ, LESLIE ANN | 3774 | §112 | Non-Final OA | — | Pending | Mar 15, 2023 |
| 18245132 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIPID-RELATED DISORDERS | Raziel Therapeutics Ltd. | CORNET, JEAN P | 1628 | §102§103 | Final Rejection | — | Pending | Mar 13, 2023 |
| 18119706 | METHODS, COMPOSITIONS, AND SYSTEMS FOR MAPPING LOCATIONS OF SINGLE MOLECULES IN MULTI-DIMENSIONAL SPACE | 13.8, Inc. | FLINDERS, JEREMY C | 1684 | §103DP | Non-Final OA | — | Pending | Mar 09, 2023 |
| 18114469 | ORAL PHARMACEUTICAL COMPOSITION COMPRISING ZONISAMIDE AND PROCESS OF PREPARATION THEREOF | Azurity Pharmaceuticals, Inc. | HUANG, GIGI GEORGIANA | 1613 | §103§112 | Final Rejection | 10d overdue | Pending | Feb 27, 2023 |
| 18113409 | MODIFIED IL-18 POLYPEPTIDES | Bright Peak Therapeutics AG | GURLEY, JAMI MICHELLE | 1647 | §103Other | Final Rejection | 22d | Pending | Feb 23, 2023 |
| 18113399 | ACTIVATABLE IL-18 POLYPEPTIDES | Bright Peak Therapeutics AG | CHATTIN, AMY MARIE | 1643 | §102§103 | Final Rejection | 5d overdue | Pending | Feb 23, 2023 |
| 18042195 | METHODS FOR REDUCING MATERNAL AUTOANTIBODIES | Marabio Systems, Inc. | TAYLOR, LIA ELAN | 1641 | §103§112 | Final Rejection | — | Pending | Feb 17, 2023 |
| 18170265 | METHODS FOR SELECTIVE CELL-FREE NUCLEIC ACID ANALYSIS | Accuscan Sciences Inc. | BUCHANAN, BAILEY CHEYENNE | 1682 | §101§102§103§112 | Non-Final OA | — | Pending | Feb 16, 2023 |
| 18164542 | SYSTEMS AND METHODS FOR CREATING BIOMOLECULE EMBEDDINGS | Seer, Inc. | THOMPSON, MILANA KAYE | §103§112 | Non-Final OA | — | Pending | Feb 03, 2023 | |
| 18105113 | SYSTEMS AND METHODS FOR MONITORING OF CANCER USING MINIMAL RESIDUAL DISEASE ANALYSIS | Predicine, Inc. | SCHLOOP, ALLISON ELIZABETH | 1683 | §101§103§112DP | Non-Final OA | — | Pending | Feb 02, 2023 |
| 18040310 | COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE | Fortem Neurosciences, Inc. | RICCI, CRAIG D | 1611 | §103 | Non-Final OA | — | Pending | Feb 02, 2023 |
| 18007032 | SYSTEMS AND METHODS FOR ASSAYING A PLURALITY OF POLYPEPTIDES | Protillion Biosciences, Inc. | BUCHANAN, BAILEY CHEYENNE | 1682 | §103 | Final Rejection | — | Pending | Jan 26, 2023 |
| 18157224 | MTORC1 MODULATORS AND USES THEREOF | Aeovian Pharmaceuticals, Inc. | HIRAKIS, SOPHIA P | 1623 | §103DP | Final Rejection | 49d overdue | Pending | Jan 20, 2023 |
| 18006142 | PARTICLES AND METHODS OF ASSAYING | Seer, Inc. | FRITCHMAN, REBECCA M | 1758 | §103§112Other | Final Rejection | — | Pending | Jan 19, 2023 |
| 18099240 | ULTRASOUND ABLATION APPARATUS AND METHODS OF USE | Current Surgical, Inc. | ASGHAR, AMINAH | 3797 | §103 | Non-Final OA | — | Pending | Jan 19, 2023 |
| 18014568 | FETAL TROPHOBLAST COMPOSITIONS AND METHODS | NextGen Jane, Inc. | SCHUBERG, LAURA J | 1631 | §102§103 | Final Rejection | — | Pending | Jan 05, 2023 |
| 18148991 | SYSTEMS AND METHODS FOR PREDICTING, DETECTING, AND MONITORING OF ACUTE ILLNESS | Evidation Health, Inc. | EVANS, ASHLEY ELIZABETH | 3687 | §103 | Non-Final OA | 16d overdue | Pending | Dec 30, 2022 |
| 18003835 | COMPOSITIONS FOR GENOME EDITING AND METHODS OF USE THEREOF | Cibus Biotechnologies, Inc. | TAKENAKA, RISA | 1632 | §112 | Non-Final OA | 27d | Pending | Dec 29, 2022 |
| 18147556 | DEEP LEARNING SUPER-RESOLUTION TRAINING FOR ULTRA LOW-FIELD MAGNETIC RESONANCE IMAGING | Neuro42 Inc. | FRITH, SEAN A | 3798 | §102§103 | Final Rejection | — | Pending | Dec 28, 2022 |
| 18069858 | MEDICAL FLUID INJECTION APPARATUS AND METHOD WITH REUSABLE PATCH | Enable Injections, Inc. | RADOMSKI, MARTIN ADAM | 3783 | §103 | Final Rejection | 8d | Pending | Dec 21, 2022 |
| 18065103 | OTOSCOPE SEAL DEVICES AND METHODS | Otonexus Medical Technologies, Inc. | MELHUS, BENJAMIN S | 3791 | §103 | Final Rejection | — | Pending | Dec 13, 2022 |
| 18064181 | CELLULAR GLYCOSAMINOGLYCAN COMPOSITIONS AND METHODS OF MAKING AND USING | Tega Therapeutics, Inc. | FRONDA, CHRISTIAN L | 1652 | DP | Final Rejection | 45d overdue | Pending | Dec 09, 2022 |
| 18074659 | METHODS AND SYSTEMS FOR PRECISION ONCOLOGY USING A MULTILEVEL BAYESIAN MODEL | Xcures, Inc. | LULTSCHIK, WILLIAM G | 3685 | §101§103 | Final Rejection | — | Pending | Dec 05, 2022 |
| 18061310 | METHODS AND SYSTEMS FOR IMPROVING AN ESTIMATION OF A PROPERTY OF A QUANTUM STATE | 1QB Information Technologies Inc. | VASQUEZ, MARKUS A | 2121 | §103§112 | Final Rejection | — | Pending | Dec 02, 2022 |
| 18061333 | METHODS AND SYSTEMS FOR DROPLET MANIPULATION | Volta Labs, Inc. | PARISI, JESSICA DANIELLE | 1684 | §103 | Final Rejection | 91d overdue | Pending | Dec 02, 2022 |
| 18059370 | METHODS OF CAPTURING CELL-FREE METHYLATED DNA AND USES OF SAME | Sinai Health System | LU, FRANK WEI MIN | 1683 | §102§103§112DP | Non-Final OA | — | Pending | Nov 28, 2022 |
| 17999358 | ENHANCEMENT OF PRODUCTIVITY IN C3 PLANTS | Oxford University Innovation Limited | STOCKDALE, JESSICA NICOLE | 1663 | §101§102§103§112 | Non-Final OA | — | Pending | Nov 18, 2022 |
| 18054676 | CELL-FREE DNA SIZE DETECTION | Accuragen Holdings Limited | SCHLOOP, ALLISON ELIZABETH | 1683 | §101§103§112 | Final Rejection | 9d | Pending | Nov 11, 2022 |
| 18054810 | SYSTEMS AND METHODS FOR ROBOTIC ENDOSCOPIC SUBMUCOSAL DISSECTION | Noah Medical Corporation | BOICE, JAMES EDWARD | 3795 | §103 | Final Rejection | 87d overdue | Pending | Nov 11, 2022 |
| 17997688 | COMPOSITIONS COMPRISING ANTI-VEGF AND NANOPARTICLES AND METHODS OF USING THE SAME FOR THE TREATMENT OF ABNORMAL OR EXCESSIVE ANGIOGENESIS | Cellviva, Inc. | LOCKARD, JON MCCLELLAND | 1647 | §102§103§112 | Non-Final OA | — | Pending | Nov 01, 2022 |
| 18046787 | MESENCHYMAL STEM CELL THERAPIES | Factor Bioscience Inc. | FOX, ALLISON M | 1633 | §102§103§112 | Non-Final OA | — | Pending | Oct 14, 2022 |
| 17963651 | SYSTEMS AND METHODS FOR ACCESS MANAGEMENT AND CLUSTERING OF GENOMIC, PHENOTYPE, AND DIAGNOSTIC DATA | Ix Layer Inc. | MISIASZEK, AMBER ALTSCHUL | 3682 | §101 | Final Rejection | 111d overdue | Pending | Oct 11, 2022 |
| 17938570 | METHOD, KIT AND SYSTEM FOR SYNCHRONOUS PRENATAL DETECTION OF CHROMOSOMAL ANEUPLOIDY AND MONOGENIC DISEASE | Beijing Biobiggen Technology Co., Ltd. | KAPUSHOC, STEPHEN THOMAS | 1683 | §103 | Non-Final OA | — | Pending | Oct 06, 2022 |
| 17938284 | DEVICES, SYSTEMS AND METHODS FOR ULTRA-LOW VOLUME LIQUID BIOPSY | Juno Diagnostics, Inc. | ZHANG, KAIJIANG | 1684 | §102§103§112Other | Non-Final OA | — | Pending | Oct 05, 2022 |
| 17936089 | METHODS AND COMPOSITIONS FOR TREATING CANCER | Engine Biosciences Pte. Ltd. | VISHNYAKOVA, ELENA VLADIMIROVNA | 1691 | §103§112 | Final Rejection | 28d overdue | Pending | Sep 28, 2022 |
| 17934945 | PHARMACOLOGY OF VISUAL CYCLE MODULATORS | Acucela Inc. | HUANG, GIGI GEORGIANA | 1613 | Other | Final Rejection | 55d | Pending | Sep 23, 2022 |
| 17946892 | METHODS AND SYSTEMS FOR SORTING BIOLOGICAL PARTICLES | Newomics Inc. | GERHARD, ALISON CLAIRE | 1797 | §102§103 | Final Rejection | — | Pending | Sep 16, 2022 |
| 17932244 | SYSTEMS AND METHODS OF DETECTING A RISK OF ALZHEIMER'S DISEASE USING A CIRCULATING-FREE MRNA PROFILING ASSAY | Superfluid Dx, Inc. | HOPPE, EMMA RUTH | 1683 | §101§103§112 | Non-Final OA | — | Pending | Sep 14, 2022 |
| 17930842 | STEM CELL STIMULATING COMPOSITIONS AND METHODS | Medicell Technologies, LLC | YU, HONG | 1614 | §103 | Non-Final OA | — | Pending | Sep 09, 2022 |
| 17905911 | Engineered PlyAB Nanopores and Uses Thereof | Rijksuniversiteit Groningen | LEE, JAE W | 1656 | §102§112 | Non-Final OA | 33d | Pending | Sep 08, 2022 |
| 17901573 | SCALABLE BIOREACTOR SYSTEMS AND RELATED METHODS OF USE | Mission Barns, Inc. | HURST, JONATHAN M | 1799 | §102§103 | Non-Final OA | 14d | Pending | Sep 01, 2022 |
| 17896355 | METHODS AND SYSTEMS FOR DETERMINING ANCESTRAL RELATEDNESS | Embark Veterinary, Inc. | AUGER, NOAH ANDREW | 1687 | §101§112Other | Non-Final OA | 34d | Pending | Aug 26, 2022 |
| 17894884 | OPHTHALMIC COMPOSITION | Sydnexis, Inc. | LEE, WILLIAM Y | 1623 | §103Other | Final Rejection | 55d | Pending | Aug 24, 2022 |
| 17894885 | OPHTHALMIC COMPOSITION | Sydnexis, Inc. | LEE, WILLIAM Y | 1623 | §103DP | Final Rejection | — | Pending | Aug 24, 2022 |
| 17894882 | OPHTHALMIC COMPOSITION | Sydnexis, Inc. | LEE, WILLIAM Y | 1623 | §103Other | Final Rejection | — | Pending | Aug 24, 2022 |
| 17880013 | ACOUSTIC OTOSCOPE | Otonexus Medical Technologies, Inc. | DOUGHERTY, SEAN PATRICK | 3791 | §102§103 | Final Rejection | 56d | Pending | Aug 03, 2022 |
| 17795204 | COMPOSITIONS FOR THE TREATMENT OF ANGIOLIPOMA | Raziel Therapeutics Ltd. | CHICKS, ASHLI ARIANA | 1626 | §103Other | Non-Final OA | — | Pending | Jul 25, 2022 |
| 17864285 | ENZYME DELIVERY SYSTEMS AND METHODS OF PREPARATION AND USE | Curemark, LLC | DUTT, ADITI | 1675 | §103DP | Final Rejection | — | Pending | Jul 13, 2022 |
| 17790797 | METHODS AND COMPOSITIONS FOR PRODUCTION OF XENOGENEIC ISLET CELLS AND TREATMENT OF INSULIN-RESISTANT OR -DEFICIENT CONDITIONS WITH THE SAME | Hangzhou Qihan Biotechnology Co., Ltd. | NOBLE, MARCIA STEPHENS | 1632 | §112 | Non-Final OA | 9d | Pending | Jul 05, 2022 |
| 17855332 | ANTI-TCR ANTIBODY MOLECULES AND USES THEREOF | Marengo Therapeutics, Inc. | PETERS, ALEC JON | 1600 | §102§103DP | Non-Final OA | — | Pending | Jun 30, 2022 |
| 17841267 | COMBINATIONS OF FLAVIVIRUS PROTEINS, PEPTIDE SEQUENCES, EPITOPES, AND METHODS AND USES THEREOF | La Jolla Institute For Immunology | CHEN, STACY BROWN | 1672 | §101§102§103§112 | Non-Final OA | 154d overdue | Pending | Jun 15, 2022 |
| 17782010 | CELL INJECTION PRINTING WITH A COAXIAL NEEDLE | Scripps Health | CARPENTER, WILLIAM R | 3783 | §102§103 | Non-Final OA | 42d overdue | Pending | Jun 02, 2022 |
| 17780227 | SYSTEMS AND DEVICES FOR SAMPLE PREPARATION AND ANALYTE DETECTION | Nucleix Ltd. | BRAZIN, JACQUELINE | 1798 | §103 | Final Rejection | 55d | Pending | May 26, 2022 |
| 17824237 | SOLID DISPERSION OF PAN-RAF KINASE INHIBITOR | Day One Biopharmaceuticals, Inc. | JANOSKO, CHASITY PAIGE | 1613 | §103 | Final Rejection | 74d overdue | Pending | May 25, 2022 |
| 17735084 | Ionic Air Flow Generator, With Emitter And Collector Stripes | Ventiva, Inc. | OSENBAUGH-STEWART, ELIZA W | 2881 | §103§112 | Final Rejection | 28d overdue | Pending | May 02, 2022 |
| 17772829 | METHODS AND SYSTEMS FOR MENSTRUALOME ANALYSIS | NextGen Jane, Inc. | GRAY, JESSICA | 1682 | §101§112DP | Final Rejection | — | Pending | Apr 28, 2022 |
| 17721831 | OPHTHALMIC COMPOSITION | Sydnexis, Inc. | TRAN, ERIC | 1629 | §103 | Non-Final OA | 8d overdue | Pending | Apr 15, 2022 |
| 17719042 | INHALABLE IMATINIB FORMULATION | Inaya Therapeutics, Inc. | LANDAU, SHARMILA GOLLAMUDI | 1653 | §103 | Final Rejection | 107d overdue | Pending | Apr 12, 2022 |
| 17766946 | METHODS AND SYSTEMS FOR ANALYZING COMPLEX GENOMIC REGIONS | Rprd Diagnostics, LLC | CASH, KAILEY ELIZABETH | 1683 | §103Other | Non-Final OA | — | Pending | Apr 06, 2022 |
| 17706163 | SYSTEMS AND METHODS OF USING SELF-ATTENTION DEEP LEARNING FOR IMAGE ENHANCEMENT | Subtle Medical, Inc. | GEBRESLASSIE, WINTA | 2677 | §103 | Final Rejection | — | Pending | Mar 28, 2022 |
| 17761866 | METHOD AND SYSTEM FOR TARGETED NUCLEIC ACID SEQUENCING | Jumpcode Genomics, Inc. | GUSSOW, ANNE | 1600 | §102§103§112 | Final Rejection | — | Pending | Mar 18, 2022 |
| 17761696 | COMPOSITIONS AND METHODS FOR TEMPLATE-FREE DOUBLE STRANDED GEOMETRIC ENZYMATIC NUCLEIC ACID SYNTHESIS | Derek Stemple | PARISI, JESSICA DANIELLE | 1684 | §103§112 | Final Rejection | 13d | Pending | Mar 18, 2022 |
| 17638760 | HEPARIN AND HEPARAN SULFATE FROM MODIFIED MAST CELLS AND METHODS OF MAKING AND USING | Tega Therapeutics, Inc. | SABILA, MERCY HELLEN | 1654 | DP | Non-Final OA | 60d overdue | Pending | Feb 25, 2022 |
| 17636527 | MATERIALS FOR DELIVERY OF TETHERABLE PROTEINS IN BONE IMPLANTS | Theradaptive, Inc. | AUDET, MAURY A | 1654 | §112 | Final Rejection | — | Pending | Feb 18, 2022 |
| 17629744 | IL-2 CYTOKINE PRODRUGS COMPRISING A CLEAVABLE LINKER | Trutino Biosciences Inc. | PATTERSON, SARAH COOPER | 1675 | §103§112 | Final Rejection | — | Pending | Jan 24, 2022 |
| 17578886 | MACHINE LEARNING METHODS TO OPTIMIZE CONCRETE APPLICATIONS AND FORMULATIONS | AlCrete Corp. | REYES, MARIELA D | 2142 | §103 | Non-Final OA | 35d overdue | Pending | Jan 19, 2022 |
| 17578149 | METHODS OF TREATING CONGENITAL ADRENAL HYPERPLASIA | Spruce Biosciences, Inc. | LEE, WILLIAM Y | 1623 | §103DP | Final Rejection | — | Pending | Jan 18, 2022 |
| 17558865 | Systems and Methods for Inferring Taxonomies in Manufacturing Processes | Oden Technologies Ltd. | ROBINSON, GRETA LEE | 2163 | §103 | Non-Final OA | 11d overdue | Pending | Dec 22, 2021 |
| 17556068 | METHODS AND SYSTEMS FOR IDENTIFYING TARGET GENES | Algen Biotechnologies, Inc. | MINCHELLA, KAITLYN L | 1685 | §103§112DP | Non-Final OA | 2d overdue | Pending | Dec 20, 2021 |
| 17552702 | SYSTEMS AND METHODS FOR PROCESSING STOOL SAMPLES | Biomesense, Inc. | SIMMONS, VALERIE MICHELLE | 1758 | §103 | Final Rejection | — | Pending | Dec 16, 2021 |
| 17619563 | A GENETIC PHARMACOPEIA FOR COMPREHENSIVE FUNCTIONAL PROFILING OF HUMAN CANCERS | Function Oncology, Inc. | VIJAYARAGHAVAN, JAGAMYA NMN | 1633 | §103§112 | Final Rejection | — | Pending | Dec 15, 2021 |
| 17616278 | TUMOR ACTIVATED T CELL ENGAGERS AND METHODS OF USE THEREOF | Janux Therapeutics, Inc. | SHUPE, ELIZABETH A | 1643 | §103Other | Non-Final OA | — | Pending | Dec 03, 2021 |
| 17520037 | METHODS AND SYSTEMS FOR GENOME ANALYSIS | University Of Utah | WOITACH, JOSEPH T | 1631 | §101 | Non-Final OA | — | Pending | Nov 05, 2021 |
| 17606514 | METHOD FOR THE TREATMENT OF PERIODONTAL DISEASE USING CHARACTERIZED MESENCHYMAL STEM CELL GROWTH FACTORS AND EXOSOMES | Direct Biologics, LLC | KIM, TAEYOON | 1631 | §103 | Final Rejection | — | Pending | Oct 26, 2021 |
| 17497373 | TISSUE GRASPING DEVICES AND RELATED METHODS | Medfree, Inc. | PRONE, CHRISTOPHER D | 3774 | §102§103§112 | Non-Final OA | 169d overdue | Pending | Oct 08, 2021 |
| 17490160 | METHOD OF DETERMINING PERCENTAGE OF IMMUNE CELL TYPES IN A SALIVA SPECIMEN | Tru Diagnostics, Inc. | JOHANSEN, PETER N. | 1644 | §101§102§103§112 | Non-Final OA | 70d | Pending | Sep 30, 2021 |
| 17491036 | PERIVASCULAR ANTI-INFLAMMATORY THERAPY FOR VENOUS THROMBOSIS | Mercator Medsystems, Inc. | KOO, BENJAMIN K | 3783 | §103 | Non-Final OA | — | Pending | Sep 30, 2021 |
| 17432138 | ACELLULAR INTRAVENOUS INFUSION INCLUDING MESENCHYMAL STEM CELL GROWTH FACTORS AND EXOSOMES | Direct Biologics, LLC | AUDET, MAURY A | 1654 | §112 | Final Rejection | — | Pending | Aug 19, 2021 |
| 17399041 | OPTIMIZED VACCINE COMPOSITIONS AND METHODS FOR MAKING THE SAME | Centivax, Inc. | FOLEY, SHANON A | 1671 | §103 | Final Rejection | — | Pending | Aug 10, 2021 |
| 17427192 | METHODS AND COMPOSITIONS FOR DEVELOPING TARGET SPECIFIC EXOSOME AND GROWTH FACTOR PRODUCTS | Direct Biologics, LLC | GOLDBERG, JEANINE ANNE | 1682 | §103§112DP | Non-Final OA | 126d overdue | Pending | Jul 30, 2021 |
| 17427046 | COMPOSITIONS AND METHODS FOR PRODUCING FOOD PRODUCTS WITH RECOMBINANT ANIMAL PROTEIN | Bond Pet Foods, Inc. | ROBINSON, HOPE A | 1652 | §112DP | Non-Final OA | — | Pending | Jul 29, 2021 |
| 17380563 | SYSTEMS AND METHODS FOR ACCESS MANAGEMENT AND CLUSTERING OF GENOMIC OR PHENOTYPE DATA | Ix Layer Inc. | VANNI, GEORGE STEVEN | 1686 | §101§103§112DP | Non-Final OA | — | Pending | Jul 20, 2021 |
| 17381105 | SINGLE USE DEVICES WITH INTEGRATED VISION CAPABILITIES | Noah Medical Corporation | WU, PAMELA F | 3795 | §103 | Non-Final OA | — | Pending | Jul 20, 2021 |
| 17418342 | METHODS AND COMPOSITIONS FOR TREATING SKIN AND HAIR DISORDERS | Direct Biologics LLC | ROGERS, ERIC JASON | 1638 | §102§103§112DP | Non-Final OA | — | Pending | Jun 25, 2021 |
| 17348876 | RNA ENCODING A PROTEIN WITH A HETEROLOGOUS SIGNAL PEPTIDE | Versameb AG | SULLIVAN, STEPHANIE LAUREN | 1635 | §103 | Final Rejection | 89d overdue | Pending | Jun 16, 2021 |
| 17291580 | TWO-GENE VECTORS FOR GENERATING CAR-T CELLS AND USES THEREOF | Iaso Biotherapeutics Usa Limited | AEDER, SEAN E | 1642 | §103§112 | Non-Final OA | 80d overdue | Pending | May 05, 2021 |
| 17196825 | METHOD AND SYSTEM FOR ESTIMATING PHYSICAL QUANTITIES OF A PLURALITY OF MODELS USING A SAMPLING DEVICE | 1QB Information Technologies Inc. | FIGUEROA, KEVIN W | 2124 | §101 | Non-Final OA | 72d overdue | Pending | Mar 09, 2021 |
| 17031584 | MICROELECTRODE ARRAY AND METHODS OF FABRICATING SAME | Paradromics Inc. | LEE, DAVINA EN-YIN | 3794 | §103 | Final Rejection | — | Pending | Sep 24, 2020 |
| 16939921 | MOLECULAR DETECTION USING LIGATION AMPLIFICATION | Aratome, LLC | SCHLOOP, ALLISON ELIZABETH | 1683 | §112 | Non-Final OA | — | Pending | Jul 27, 2020 |
| 16960543 | HETERODUPLEX NUCLEIC ACID MOLECULES AND USES THEREOF | Atrium Therapeutics, Inc. | VIVLEMORE, TRACY ANN | 1638 | §112Other | Non-Final OA | 21d | Pending | Jul 07, 2020 |
| 16874533 | COMPOSITIONS AND METHODS FOR INCREASING THE POLLINATION PERFORMANCE OF BEES | CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS | NEAGU, IRINA | 1629 | §103 | Non-Final OA | — | Pending | May 14, 2020 |
| 16841487 | METHODS OF MANUFACTURING INJECTABLE MICROGEL SCAFFOLDS | Tempo Therapeutics, Inc. | HAGOPIAN, CASEY SHEA | 1617 | §103DP | Non-Final OA | 18d overdue | Pending | Apr 06, 2020 |
| 16718092 | NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF | Atrium Therapeutics, Inc. | CANELLA, KAREN A | 1643 | §103 | Final Rejection | 118d overdue | Pending | Dec 17, 2019 |
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